Multigram-Scale Syntheses, Stability, and Photoreactions of A2A Adenosine Receptor Antagonists with 8-Styrylxanthine Structure: Potential Drugs for Parkinson's Disease

Journal of Organic Chemistry

Volumn 69, Issue 10, 2004, Pages 3308-3318

  Hockemeyer, Jörg ^a   Burbiel, Joachim C ^a   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CATALYSIS; DERIVATIVES; DIMERS; DRUG PRODUCTS; ISOMERS; PHOTOSENSITIVITY; SYNTHESIS (CHEMICAL); ULTRAVIOLET RADIATION;

ADENOSINE RECEPTORS; XANTHINE FORMATION;

NITROGEN COMPOUNDS;

3 (3 HYDROXYPROPYL) 8 [2 (3 METHOXYPHENYL)VINYL] 7 METHYL 1 PROP 2 YNYL 3,7 DIHYDROPURINE 2,6 DIONE; 6 AMINO 5 CINNAMOYLAMINOURACIL; 8 STYRYLXANTHINE; ADENOSINE A2A RECEPTOR ANTAGONIST; HEXAMETHYLDISILAZANE; ISTRADEFYLLINE; MSX 2; MXS 3; PHOSPHORIC ACID [3 [8 [2 (3 METHOXYPHENYL)VINYL] 7 METHYL 2,6 DIOXO 1 PROP 2 YNYL 1,2,6,7 TETRAHYDROPURIN 3 YL]PROPYL]ESTER DISODIUM SALT; PRODRUG; UNCLASSIFIED DRUG; URACIL DERIVATIVE; XANTHINE DERIVATIVE;

ALKYLATION; ARTICLE; CATALYSIS; DIMERIZATION; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; PARKINSON DISEASE; PHOTOREACTIVITY; PHOTOSENSITIVITY; SUNLIGHT; ULTRAVIOLET IRRADIATION;

ANIMALS; ANTIPARKINSON AGENTS; DIMERIZATION; MOLECULAR STRUCTURE; PHOTOCHEMISTRY; PURINES; RATS; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; XANTHINES;

EID: 2442520220     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0358574     Document Type: Article

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