Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 5, 2004, Pages 1091-1099

  Kurimoto, Ayumu ^a   Ogino, Tetsuhiro ^a   Ichii, Shinji ^a   Isobe, Yoshiaki ^a   Tobe, Masanori ^a   Ogita, Haruhisa ^a   Takaku, Haruo ^a   Sajiki, Hironao ^b   Hirota, Kosaku ^b   Kawakami, Hajime ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

8 hydroxyadenines; HCV; Imiquimod; Interferon inducer; Orally active

Indexed keywords

9 BENZYL 8 HYDROXY 2 (2 METHOXYETHOXY)ADENINE; ADENINE DERIVATIVE; IMIQUIMOD; INTERFERON INDUCING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; HYDROPHILICITY; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN;

HEPATITIS C VIRUS;

EID: 10744229283     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.12.008     Document Type: Article

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