A small molecule-kinase interaction map for clinical kinase inhibitors

Nature Biotechnology

Volumn 23, Issue 3, 2005, Pages 329-336

  Fabian, Miles A ^a   Biggs III, William H ^a   Treiber, Daniel K ^a   Atteridge, Corey E ^a   Azimioara, Mihai D ^a,b   Benedetti, Michael G ^a,c   Carter, Todd A ^a   Ciceri, Pietro ^a   Edeen, Philip T ^a   Floyd, Mark ^a   Ford, Julia M ^a   Galvin, Margaret ^a   Gerlach, Jay L ^a,d   Grotzfeld, Robert M ^a   Herrgard, Sanna ^a   Insko, Darren E ^a   Insko, Michael A ^a,e   Lai, Andiliy G ^a   Lélias, Jean Michel ^a   Mehta, Shamal A ^a   Milanov, Zdravko V ^a   Velasco, Anne Marie ^a   Wodicka, Lisa M ^a   Patel, Hitesh K ^a   Zarrinkar, Patrick P ^a   Lockhart, David J ^a   more..

^a Ambit Biosciences   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^e Metabasis Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; DRUG DOSAGE; ENZYME INHIBITION; PROTEINS; STRUCTURE (COMPOSITION);

CLINICAL KINASE INHIBITORS; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); MOLECULE-KINASE INTERACTION MAP;

ENZYME KINETICS;

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE LCK; DRUG; ESCHERICHIA COLI PROTEIN; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; ENZYME METABOLISM; ENZYME SPECIFICITY; GENE MAPPING; GENE TARGETING; MEASUREMENT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG DESIGN; ESCHERICHIA COLI; EVALUATION; METABOLISM; METHODOLOGY; PROTEIN ANALYSIS; PROTEIN BINDING;

ANIMALIA;

DRUG DESIGN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICROCHEMISTRY; PHARMACEUTICAL PREPARATIONS; PIPERAZINES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN KINASE INHIBITORS; PYRIMIDINES;

EID: 19744365702     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1068     Document Type: Article

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