Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck-A selectivity insight

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 12, 2002, Pages 1687-1690

  Burchat, Andrew F ^a   Calderwood, David J ^a   Friedman, Michael M ^a   Hirst, Gavin C ^a   Li, Biqin ^a   Rafferty, Paul ^a   Ritter, Kurt ^a   Skinner, Barbara S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PROTEIN KINASE LCK; PYRIMIDINE DERIVATIVE; ANGIOPOIETIN RECEPTOR; DRUG DERIVATIVE; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN LCK KINASE; PROTEIN TYROSINE KINASE; PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; MALE; RAT; SPRAGUE DAWLEY RAT; ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ANALYSIS; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; ENZYME INHIBITORS; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MALE; MODELS, MOLECULAR; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; ANIMAL; HUMAN;

ANIMALIA;

EID: 0037124207     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00196-8     Document Type: Article

References (14)