KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: The role of the epithelium, cyclic nucleotides and K + channels

British Journal of Pharmacology

Volumn 142, Issue 7, 2004, Pages 1105-1114

  Wu, Bin Nan ^a   Lin, Rong Jyh ^b   Lo, Yi Ching ^a   Shen, Kuo Pyng ^a   Wang, Chao Chuan ^a   Lin, Young Tso ^a   Chen, Ing Jun ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b FOOYIN UNIVERSITY   (Taiwan)

Author keywords

Cyclic AMP; Cyclic GMP; K+ channels; KMUP 1; Soluble guanylate cyclase; Tracheal smooth muscle cells

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; 7 [2 [4 (2 CHLOROPHENYL)PIPERAZINYL]ETHYL] 1,3 DIMETHYLXANTHINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; APAMIN; BRONCHODILATING AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; CARBACHOL; CHARYBDOTOXIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE; GLIBENCLAMIDE; GUANYLATE CYCLASE; ISOBUTYLMETHYLXANTHINE; KMUP 1; LEMAKALIM; MILRINONE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; POTASSIUM CHANNEL; ROLIPRAM; TETRYLAMMONIUM; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; XANTHINE DERIVATIVE; ZAPRINAST;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CELL CULTURE; CELL LEVEL; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; IC 50; LUNG COMPLIANCE; LUNG FUNCTION; LUNG RESISTANCE; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE RELAXATION; TRACHEA MUCOSA; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANYLATE CYCLASE; GUINEA PIGS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITORS; PIPERIDINES; POTASSIUM CHANNELS; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUCOSA; TRACHEA; VASODILATOR AGENTS; XANTHINES;

EID: 4143107895     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705791     Document Type: Article

References (34)

1. ABDERRAHMANE, A., SALVAIL, D., DUMOULIN, M., GARON, J., CADIEUX, A. & ROUSSEAU, E. (1998). Direct activation of K(Ca) channel in airway smooth muscle by nitric oxide:, involvement of a nitrothiosylation mechanism? Am. J. Respir. Cell. Mol. Biol., 19, 485-497.
2. ALLEN, S.L., BOYLE, J.P., CORTIJO, J., FOSTER, R.W., MORGAN, G.P. & SMALL, RC. (1986). Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis. Br. J. Pharmacol., 89, 395-405.
3. ARCH, J.R.S., BUCKLE, D.R., BUMSTEAD, J., CLARKE, G.D., TAYLOR, J.F. & TAYLOR, S.G. (1988). Evaluation of the potassium channel activator cromakalim (BRL34915) as a bronchodilator in the guinea-pig: comparison with nifedipine. Br. J. Pharmacol., 95, 763-770.
4. BARNES, P.J. (1995), Cyclic nucleotides and phosphodiesterases and airway function. Eur. Respir. J., 8, 457-462.
5. BEAVO, J.A. (1995). Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev., 75, 725-748.
6. BERNAREGGI, M.M., BELVISI, M.G., PATEL, H., BARNES, P.J. & GIEMBYCZ, M.A. (1999). Anti-spasmogenic activity of isoenzymeselective phosphodiesterase inhibitors in guinea-pig trachealis. Br. J. Pharmacol., 128, 327-336.
7. BOLOTINA, V.M., NAJIBI, S., PALACINO, J.J., PAGANO, P.J. & COHEN, R.A. (1994). Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature, 368, 850-853.
8. BOLTON, T., LANG, R. & TAKEWAKI, T. (1984). Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric artery. J. Physiol., 351, 549-572.
9. DE BOER, J., PHILPOTT, K.J., VAN AMSTERDAM, R.G.M., SHAHID, M., ZAAGSMA, H. & NICHOLSON, CD. (1992). Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. Br. J. Pharmacol., 106, 1028-1034.
10. FOLKERTS, G. & NIJKAMP, F.P. (1998). Airway epithelium: more than just a barrier! Trends Pharmacol. Sci., 19, 334-341.
11. GRUETTER, C.A., CHILDERS, C.E., BOSSERMAN, M.K., LEMKE, S.M., BALL, J.G. & VALENTOVIC, M.A. (1989). Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways. Am. Rev. Respir. Dis., 139, 1192-1197.
12. HAKONARSON, H., HERRICK, D.J., SERRANO, P.G. & GRUNSTEIN, M.M. (1996). Mechanism of cytokine-induced modulation of β-adrenoceptor responsiveness in airway smooth muscle. J. Clin. Invest., 97, 2593-2600.
13. m phosphodiesterase. Biochim. Biophys. Acta, 429, 485-497.
14. HSU, T.H., LAI, Y.L. & KOU, Y.R. (1998). Acetylcholine and tachykinin receptor antagonists attenuate wood smoke-induced bronchoconstriction in guinea pigs. Eur. J. Pharmacol., 360, 175-183.
15. HWANG, T.L., WU, C.C. & TENG, C.M. (1999). YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. Br. J. Pharmacol., 128, 577-584.
16. KATSUKI, S. & MURAD, F. (1977). Regulation of adenosine cyclic 3′,5′-monophosphate and guanosine cyclic 3′,5′- monophosphate levels and contractility in bovine tracheal smooth muscle. Mol. Pharmacol., 13, 330-341.
17. + channels in cultured vascular smooth muscle. Circ. Res., 74, 471-476.
18. + Channels. Br. J. Pharmacol., 135, 1159-1166.
19. LINCOLN, T.M. & CORNWELL, T.L. (1991). Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels, 28, 129-137.
20. MATSUSHITA, Y., HENMI, S., MURAKI, K., IMAIZUMI, Y. & WATANABE, M. (2000). Cromakalim-induced membrane current in guinea-pig tracheal smooth muscle cells. Eur. J. Pharmacol., 389, 51-58.
21. MCCAIG, D.J. & DE JONCKHEERE, B. (1989). Effect of cromakalim on bronchoconstriction evoked by cholinergic nerve stimulation in guinea-pig isolated trachea. Br. J. Pharmacol., 98, 662-668.
22. MURAD, F., MITTAL, C.K., ARNOLD, W.P., KATSUKI, S. & KIMURA, H. (1978). Guanylate cyclase: activation by azide, nitrocompounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv. Cyclic Nucleotide Res., 9, 145-158.
23. MURPHY, M.E. & BRAYDEN, J.E. (1995). Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitivity potassium channels. J. Physiol., 486, 47-58.
24. MURTHY, K.S., ZHOU, H. & MAKHLOUF, G.M. (2002). PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle. Am. J. Physiol. Cell Physiol., 282, C508-C517.
25. NIJKAMP, F.P., VAN DER LINDE, H.J. & FOLKERTS, G. (1993). Nitric oxide synthesis inhibitors induce airway hyperresponsiveness in the guinea pig in vivo and in vitro: role of the epithelium. Am. Rev. Respir. Dis., 148, 727-734.
26. POLSON, J.B., KRZANOWSKI, J.J. & SZENTIVANYI, A. (1985). Correlation between inhibition of a cyclic GMP phosphodiesterase and relaxation of canine tracheal smooth muscle. Biochem. Pharmacol., 34, 1875-1879.
27. RABE, K.F., MAGNUSSEN, H. & DENT, G. (1995). Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur. Respir. J., 8, 637-642.
28. SERAFIN, W.E. (1996). Drugs used in the treatment of asthma. Goodman and Gilman's The Pharmacological Basis of Therapeutics, In: ed. HARDMAN, J.G., LIMBIRD, L.E., MOLINOFF, P.B., RUDDON, R.W. & GILMAN A.G., New York: McGraw-Hill, pp. 659-682.
29. TANAKA, H., OGAWA, K., TAKAGI, K., SATAKE, T. & HIDAKA, H. (1991). Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin. Exp. Pharmacol. Physiol., 18, 163-168.
30. TUCKER, J.F., BRAVE, S.R., CHARALAMBOUS, L., HOBBS, A.J. & GIBSON, A. (1990). L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br. J. Pharmacol., 100, 663-664.
31. + currents in smooth muscle cells of intact rat small arteries. J. Physiol., 500, 617-630.
32. 1-adrenoceptor antagonist derived from vanillin. Biochem. Pharmacol., 48, 101-109.
33. + channels opening activities in rat aortic smooth muscle. Br. J. Pharmacol., 134, 265-274.
34. ZHOU, H.L. & TORPHY, T.J. (1991). Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators. J. Pharmacol. Exp. Ther., 258, 972-978.