Mechanism-based design of a protein kinase inhibitor

Nature Structural Biology

Volumn 8, Issue 1, 2001, Pages 37-41

  Parang, Keykavous ^a   Till, Jeffrey H ^b   Ablooglu, Ararat J ^c   Kohanski, Ronald A ^c   Hubbard, Stevan R ^b   Cole, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INSULIN RECEPTOR; PROTEIN KINASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DISSOCIATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CHICKENS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; KINETICS; MAGNESIUM; MODELS, MOLECULAR; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; SUBSTRATE SPECIFICITY;

EID: 0035165210     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/83028     Document Type: Article

References (30)