8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8- isopropyl-adenine: Highly potent and selective PDE4 inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1237-1243

  Whitehead, John W F ^a   Lee, Gary P ^a   Gharagozloo, Parviz ^a   Hofer, Peter ^a   Gehrig, André ^a   Wintergerst, Peter ^a   Smyth, Donald ^a,b   McCoull, William ^a,c   Hachicha, Mohamed ^a   Patel, Aniket ^a   Kyle, Donald J ^a  

^a PURDUE PHARMA L P   (United States)

^b OSI Pharmaceuticals   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 6 ETHYLAMINO 8 ISOPROPYL 3H PURINE; 3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 8 [1,1 DIMETHYL 3 (THIOPHEN 3 YLOXY)ETHYL] 3H PURIN 6 YLAMINE HEMIFUMARATE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG; V 11689;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BACULOVIRUS EXPRESSION SYSTEM; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; LUNG; TISSUE SPECIFICITY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADENINE; HUMANS; ISOENZYMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13944276311     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030603w     Document Type: Article

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