Development of a purine-scaffold novel class of hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 11, 2002, Pages 3555-3564

  Chiosis, Gabriela ^a   Lucas, Brian ^a   Shtil, Alexander ^a   Huezo, Henri ^a   Rosen, Neal ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORO 9 PENT 4 YNYL 8 (2 CHLORO 3,4,5 TRIMETHOXYBENZYL) 9H PURIN 6 YLAMINE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG SYNTHESIS; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IC 50; ONCOGENE NEU;

ALKYLATION; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE LIBRARY; PROTEIN BINDING; PURINES; RECEPTOR, ERBB-2; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036836964     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00253-5     Document Type: Article

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