Synthesis and antimycobacterial activity of 6-arylpurines: The requirements for the N-9 substituent in active antimycobacterial purines

Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2002, Pages 1383-1386

  Gundersen, Lise Lotte ^a   Nissen Meyer, Jon ^a   Spilsberg, BjØrn ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 6 (2 FURYL) 9 (BETA DEXTRO RIBOFURANOSYL) 9H PURINE; 2 CHLORO 6 (2 FURYL) 9 (TETRAHYDRO 2H PYRAN 2 YL) 9H PURINE; 2 CHLORO 9 (TETRAHYDRO 2H PYRAN 2 YL) 6 (2 THIENYL) 9H PURINE; 6 (2 FURYL) 1H PURINE; 6 (2 FURYL) 9 (2 PHENYLETHYL) 9H PURINE; 6 (2 FURYL) 9 (2 PROPEN 1 YL) 9H PURINE; 6 (2 FURYL) 9 (BETA DEXTRO RIBOFURANOSYL) 9H PURINE; 6 (2 FURYL) 9 (TETRAHYDRO 2H PYRAN 2 YL) 9H PURINE; 6 (2 FURYL) 9 METHYL 9H PURINE; 9 (BETA DEXTRO RIBOFURANOSYL) 6 (2 THIENYL) 9H PURINE; 9 (CYCLOHEXYLMETHYL) 6 (2 FURYL) 9H PURINE; 9 (TETRAHYDRO 2H PYRAN 2 YL) 6 (2 THIENYL) 9H PURINE; 9 BENZYL 2 CHLORO 6 (2 FURYL)PURINE; 9 BENZYL 6 (2 FURYL) 9H PURINE; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; ETHAMBUTOL; ISONIAZID; KANAMYCIN; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG RESISTANCE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VERO CELL;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; COLONY COUNT, MICROBIAL; FURANS; HUMANS; MACROPHAGES; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PURINES; VERO CELLS;

EID: 0037075792     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110284     Document Type: Article

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