Exploiting chemical libraries, struture, and genomics in the search for kinase inhibitors

Science

Volumn 281, Issue 5376, 1998, Pages 533-538

  Gray, Nathanael S ^a   Wodicka, Lisa ^b   Thunnissen, Andy Mark W H ^a   Norman, Thea C ^a   Kwon, Soojin ^a   Espinoza, F Hernan ^c   Morgan, David O ^c   Barnes, Georjana ^a   LeClerc, Sophie ^d   Meijer, Laurent ^d   Kim, Sung Hou ^a   Lockhart, David J ^b   Schultz, Peter G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Thermo Fisher Scientific   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STATION BIOLOGIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; FUNGAL PROTEIN; OLOMOUCINE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PURINE DERIVATIVE; PURVALANOL; ROSCOVITINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL CYCLE; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; GENE EXPRESSION REGULATION; GENOME; HUMAN; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

ADENINE; BINDING SITES; CDC2-CDC28 KINASES; CDC28 PROTEIN KINASE, S CEREVISIAE; CELL DIVISION; CRYSTALLOGRAPHY, X-RAY; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HUMANS; HYDROGEN BONDING; OLIGONUCLEOTIDE PROBES; PHOSPHATES; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PURINES; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0032563315     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5376.533     Document Type: Article

References (42)

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42. We thank A. Murray for providing the CDC28 temperature-sensitive strains and for helpful discussions, C. Mimotopes for providing derivatized pins, D. Drubin and members of his lab, the National Cancer Institute for performing cellular screens, and M.-H. Ho for help with expression data analysis. Supported by the Director, Office of Health Effects Research of the U.S. Department of Energy (to S.-H. K. and P.G.S.), the Association pour la Recherche sur le Cancer (ARC9157 to L.M.), the Counsil Regional de Bretagne (to L.M.), and the CaP Cure Foundation. N.S.G. is supported by a NSF predoctoral fellowship and A.-M.T. by a long-term fellowship from the Human Frontier Science Program. The coordinates have been deposited with Protein Data Bank with ID code 1CKP.