Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4288-4312

  Norman, M H ^a   Chen, N ^a   Chen, Z ^a   Fotsch, C ^a   Hale, C ^a   Han, N ^a   Hurt, R ^a   Jenkins, T ^a   Kincaid, J ^a   Liu, L ^a   Lu, Y ^a   Moreno, O ^a   Santora, V J ^a   Sonnenberg, J D ^a   Karbon, W ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; PYRROLO[3,2 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG USE; HUMAN; HUMAN CELL; OBESITY; STRUCTURE ACTIVITY RELATION;

ANTI-OBESITY AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES; MODELS, BIOLOGICAL; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034597613     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000269t     Document Type: Article

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