Synthesis and activity of 2,6,9-trisubstituted purines

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 21, 1997, Pages 2697-2702

  Schow, Steven R ^a   Mackman, Richard L ^a   Blum, Cheri L ^a   Brooks, Eric ^a   Horsma, Amy G ^a   Joly, Alison ^a   Kerwar, Suresh S ^a   Lee, Gavin ^a   Shiffman, Dov ^a   Nelson, Marek G ^a   Wang, Xingbo ^a   Wick, Michael M ^a   Zhang, Xiaoming ^a   Lum, Robert T ^a  

^a CV THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PURINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; LIBRARY; MAMMAL CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0030869845     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10076-2     Document Type: Article

References (13)

1. Reviewed in: Progress in Cell Cycle Research; Meijer, L; Guidet, S; Tung, H. Y., Eds; Plenum: New York, 1995; Vol 1.
2. Reviewed by: Fotedar, R.; Fotedar, A. In Progress in Cell Cycle Research; Meijer, L.; Guidet, S.; Tung, H. Y. L., Eds.; Plenum: New York, 1995; Vol 1.
3. (a) Vesely, J.; Havilicek, L.; Strnad, M.; Blow, M; Donella-Deanna, A.; Letham, D. S.; Kato, J. Y.; Detivaud, L.; LeClerc, S.; Meijer, L. Eur. J. Biochem. 1994, 224, 771;
4. (b) Meijer, L. In Progress in Cell Cycle Research; Meijer, L.; Guidet, S.; Tung, H. Y. L., Eds.; Plenum: New York, 1995; Vol 1, p 351.
5. Havlicek, L.; Hanus, J.; Vesely, J.; Lelerc, S.; Meijer, L.; Shaw, G.; Strnad, M. J. Med. Chem. 1997, 40, 408.
6. 2
7. (a) Norman, T. C.; Gray, N. S.; Koh, J. T.; Schulte, P. G. J. Am. Chem. Soc. 1996, 118, 7430;
8. (b) Nugiel, D. A.; Cornelius, L. A. M.; Corbett, J. W. J. Org. Chem. 1997, 62, 201;
9. Gray, N. S.; Kwon, S.; Schultz, P. G. Tetrahedron Lett. 1997, 38, 1161.
10. Lum, R. T.; Blum, C.; Brooks, E. E.; Horsma, A. G.; Kerwar, S. S.; Mackman, R. L.; Meyer, S. M.; Nelson, M. G.; Wang, X.; Joly, W.; Wick, M. M.; Shiffman, D.; Schow, S. R. In preparation.
11. For a comprehensive review of purine chemistry see: Lister, J. H., Ed. The Purines; Suppl. 1; Wiley: Chichester, U.K. 1996.
12. (a) De Azevedo,W. F.; Leclerc, S.; Meijer, L.; Havlicek, L.; Strnad, M.; Kim, S. H. Eur. J. Biochem. 1997, 243;
13. (b) Schulze-Gahmen, U.; Brandsen, J.; Jones, H. D.; Morgan, D. O.; Meijer, L. Proteins: Struct., Funct., Genet. 1995, 22, 378.