Adenosine A(2A) antagonists with potent anti-cataleptic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 18, 1997, Pages 2349-2352

  Shimada, Junichi ^a   Koike, Nobuaki ^a   Nonaka, Hiromi ^a   Shiozaki, Shizuo ^a   Yanagawa, Koji ^a   Kanda, Tomoyuki ^a   Kobayashi, Hiroyuki ^a   Ichimura, Michio ^a   Nakamura, Joji ^a   Kase, Hiroshi ^a   Suzuki, Fumio ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; CYCLOHEXYLADENOSINE; HALOPERIDOL; ISTRADEFYLLINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CATALEPSY; CELL MEMBRANE; CHIRALITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FOREBRAIN; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIGHT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 17044440786     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00440-X     Document Type: Article

References (14)

1. Fredholm, B. B.; Abbracchio, M. P.; Burnstock, G.; Daly, J. W.; Harden, T. K.; Jacobson, K. A.; Leff, P.; Williams, M. Pharmacol. Rev. 1994, 46, 143-156.
2. (a) Jarvis, M. F.; Williams, M. Eur. J. Pharmacol. 1989, 168, 243-246.
3. (b) Parkinson, F. E.; Fredholm, B. B. Naunyn Schmiedebergs Arch. Pharmacol. 1990, 342, 85-89.
4. (c) Martinez-Mir, M. I.; Probst, A.; Palacios, J. M. Neurosciene 1991, 42, 697-706.
5. Fredholm, B. B. Trends Pharmacol. Sci. 1980, 1, 129-132.
6. Baraldi, P. G.; Cacciari, B.; Spalluto, G.; Borioni, A.; Viziano, M.; Dionisotti, S.; Ongini, E. Cur. Med. Chem. 1995, 2, 707-722.
7. Shimada, J.; Suzuki, P.; Nonaka, H.; Ishii, A.; Ichikawa, S. J. Med. Chem. 1992, 35, 2342-2345.
8. (a) Jackson, E. K.; Herzer, W. A.; Suzuki, F. J. Pharmacol. Exp. Ther. 1993, 267, 1304-1310.
9. (b) Nonaka, H.; Ichimura, M.; Takeda, M.; Nonaka, Y.; Shimada. J.; Suzuki, F.; Yamaguchi, K.; Kase, H. Eur. J. Pharmacol. 1994, 267, 335-341.
10. Kanda, T.; Shiozaki, S.; Shimada, J.; Suzuki, F.; Nakamura, J. Eur. J. Pharmacol. 1994, 256, 263-268.
11. 5
12. Nonaka, Y.; Shimada, J.; Nonaka, H.; Koike, N.; Aoki, N.; Kobayashi, H.; Kase, H.; Yamaguchi, K.; Suzuki, F. J. Med. Chem. 1993, 36, 3731-3733.
13. 50 values with 95% confidence limits were calculated by means of the Probit method (n = 10).
14. 4: C, 62.48; H, 6.29; H, 14.57. Found: C, 62.52; H, 6.53, N, 14.56.