A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a]pyridine moiety

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 4062-4079

  Abe, Yoshito ^a   Kayakiri, Hiroshi ^a   Satoh, Shigeki ^a   Inoue, Takayuki ^a   Sawada, Yuki ^a   Inamura, Noriaki ^a   Asano, Masayuki ^a   Aramori, Ichiro ^a   Hatori, Chie ^a   Sawai, Hiroe ^a   Oku, Teruo ^a   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; 3 BROMO 8 [2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 3 BROMO 8 [[2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMAMIDOACETYL] N METHYLAMINO]BENZYL]OXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 8 [[3 (N ACYLGLYCYL N METHYLAMINO) 2,6 DICHLOROBENZYL]OXY] 3 HALO 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 8 [[3 [N [3 (6 ACETAMIDOPYRIDIN 3 YL)ACRYLOYLGLYCYL] N METHYLAMINO] 2,6 DICHLOROBENZYL]OXY] 2 METHYLQUINOLINE; BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRONCHOSPASM; CHO CELL; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN CELL; INFLAMMATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOCONSTRICTION; CHO CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HUMANS; ILEUM; MALE; PYRIDINES; QUINOLINES; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 15644367578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980300f     Document Type: Article

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