A non-ATP-competitive inhibitor of BCR-ABL overrrides imatinib resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 6, 2005, Pages 1992-1997

  Gumireddy, Kiranmai ^a   Baker, Stacey J ^a   Cosenza, Stephen C ^a   John, Premila ^a   Kang, Anthony D ^a   Robell, Kimberly A ^a   Reddy, M V Ramana ^a   Reddy, E Premkumar ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gleevec; ON012380; Substrate competitive

Indexed keywords

ADENOSINE TRIPHOSPHATE; BCR ABL PROTEIN; IMATINIB; ONO 12380; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING COMPETITION; BINDING KINETICS; BINDING SITE; BLOOD TOXICITY; CANCER REGRESSION; CANCER RESISTANCE; CELL DEATH; CHRONIC MYELOID LEUKEMIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM CARE; MOUSE; MUTATION; NONHUMAN; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; RODENT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CELL DEATH; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MICE; MICE, NUDE; MOLECULAR STRUCTURE; MUTATION; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; RECOMBINANT PROTEINS;

ANIMALIA; RODENTIA;

EID: 13844261144     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408283102     Document Type: Article

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