Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

Journal of Medicinal Chemistry

Volumn 47, Issue 24, 2004, Pages 5833-5836

  Altmann, Eva ^a   Cowan Jacob, Sandra W ^a   Missbach, Martin ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE INHIBITOR; NITRILE; PURINE DERIVATIVE;

ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; IC 50; X RAY ANALYSIS;

ANIMALS; BINDING SITES; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; MODELS, MOLECULAR; NITRILES; PURINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8644276353     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0493111     Document Type: Article

References (18)

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