Adenine derived inhibitors of the molecular chaperone HSP90 - SAR explained through multiple X-ray structures

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 325-328

  Dymock, Brian ^a   Barril, Xavier ^a   Beswick, Mandy ^a   Collier, Adam ^a   Davies, Nicholas ^a   Drysdale, Martin ^a   Fink, Alexandra ^a   Fromont, Christophe ^a   Hubbard, Roderick E ^a   Massey, Andrew ^a   Surgenor, Allan ^a   Wright, Lisa ^a  

^a RiboTargets Ltd   (United Kingdom)

Author keywords

Adenine inhibitors; Chaperone; HSP70; HSP90; Raf 1

Indexed keywords

ADENINE; BENZOQUINONE DERIVATIVE; CHAPERONE; ENZYME; GELDANAMYCIN; PROTEIN INHIBITOR; RADICICOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

EID: 0347360283     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.011     Document Type: Article

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