Strategies to overcome resistance to targeted protein kinase inhibitors

Nature Reviews Drug Discovery

Volumn 3, Issue 12, 2004, Pages 1001-1010

  Daub, Henrik ^a   Specht, Katja ^b   Ullrich, Axel ^b,c  

^a Axxima Pharmaceuticals AG   (Germany)

^b AGENCY FOR SCIENCE   (Singapore)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (2,6 DICHLOROPHENYL) 2 (4 FLUORO 3 METHYLANILINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE; ABELSON KINASE; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; DASATINIB; ERLOTINIB; GEFITINIB; HEAT SHOCK PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SEMAXANIB; STEM CELL FACTOR; SUNITINIB; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; KIDNEY CARCINOMA; LEUKEMOGENESIS; LUNG NON SMALL CELL CANCER; MEDICAL DOCUMENTATION; MUTATIONAL ANALYSIS; NONHUMAN; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN KINASE INHIBITORS;

EID: 10444280878     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1579     Document Type: Review

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