Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 19, 2000, Pages 2167-2170

  Arnold, Lee D ^a   Calderwood, David J ^a   Dixon, Richard W ^a   Johnston, David N ^b   Kamens, Joanne S ^a   Munschauer, Rainer ^a   Rafferty, Paul ^b   Ratnofsky, Sheldon E ^a  

^a BASF Bioresearch Corporation   (United States)

^b BASF Pharma   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; PROTEIN TYROSINE KINASE INHIBITOR; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; HUMAN; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); PYRIMIDINES; PYRROLES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0034597072     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00441-8     Document Type: Article

References (17)