Antimycobacterial Agents. 1. Thio Analogues of Purine

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 273-276

  Pathak, Ashish K ^a   Pathak, Vibha ^a   Seitz, Lainne E ^a   Suling, William J ^a   Reynolds, Robert C ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (BENZYLTHIO)PURINE; 6 (DECYLTHIO)PURINE; 9 (ETHYLCARBOXYMETHYL) 6 (DECYLTHIO) 9H PURINE; 9 (ETHYLCARBOXYMETHYL) 6 (DODECYLTHIO) 9H PURINE; ANTIMYCOBACTERIAL AGENT; HETEROCYCLIC COMPOUND; PURINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; BACTERIAL STRAIN; CHEMICAL MODIFICATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VERO CELL;

ANTITUBERCULAR AGENTS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PURINES; PYRIDINES; PYRIMIDINES; SULFIDES;

EID: 0346100650     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030389b     Document Type: Conference Paper

References (20)

1. (a) World Health Organization. Anti-tuberculosis drug resistance in the world. The WHO/IUATLD global project on anti-tuberculosis drug resistance surveillance, 1997.
2. (b) Bastian, I.; Colebunders, R. Drugs 1999, 58, 633-661.
3. (c) Butler D. New fronts in an old war. Nature 2000, 406, 670-672.
4. (a) Bodiang, C. K. Issue facing TB control (2.1) Tuberculosis control in refugee populations: A focus on developing countries. Scot. Med. J. 2000, 45, 25-28.
5. (b) Van Scoy, R. E.; Wilkowske, C. J. Antimycobacterial therapy. Mayo Clin. Proc. 1999, 74, 1038-1048.
6. (c) Long, R. Drug-resistant tuberculosis. Can. Med. Assoc. J. 2000, 163, 425-428.
7. (a) Gazdic, A. Correlation between increased incidence of pulmonary tuberculosis and AIDS. Med. Arch. 1998, 52, 207-209.
8. (b) Pozniak, A. HIV-associated tuberculosis in the era of HAART. Int. J. Tuberc. Lung Dis. 2000, 4, 993-994.
9. Cole, S. T.; Brosch, R.; Parkhill, J. et. al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998, 393, 537-544.
10. Orme, I.; Secrist, J.; Ananthan, S. et. al. Search for new drugs for treatment of tuberculosis. Antimicrob. Agents Chemother. 2001, 45, 1943-1946; http://taacf.org.
11. Jacobson, K. A.; Daly, J. W.; Manganiello, V. In Purines in cellular signaling: Targets for new drugs; Springer: New York, 1990.
12. (a) Norbury, C.; Nurse, P. Animal cell cycles and their control. Annu. Rev. Biochem. 1992, 61, 441-470.
13. (b) Morgan, D. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 1997, 13, 261-291.
14. (c) Hengst, L.; Reed, S. I. Inhibitors of the Cip/Kip family. Curr. Topics Microb. Immunol. 1998, 227, 25-41.
15. (a) Bakkestuen, A. K.; Gundersen, L.-L.; Langli, G.; Liu, F.; Nolsoe, J. M. J. 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis. Bioorg. Med. Chem. Lett. 2000, 10, 1207-1210.
16. (b) Scozzafava, A.; Mastrolorenzo, A.; Supuran, C. T. Antimycobacterial activity of 9-sulfonylated/selfenylated-6-mercaptopurine derivatives. Bioorg. Med. Chem. Lett. 2001, 11, 1675-1678.
17. (c) Gundersen, L.-L.; Nissen-Meyer, J. N.; Spilsberg, B. Synthesis and antimycobacterial activity of 6-arylpurines: The requirements for the N-9 substituent in active antimycobacterial purines. J. Med. Chem. 2002, 45, 1383-1386.
18. Suling, W. J.; Reynolds, R. C.; Barrow, E. L.; Wilson, L. N.; Piper, J. R.; Barrow, W. W. Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase. Antimicrob. Agents Chemother. 1998, 42, 811-815.
19. Skinner, P. S.; Furney, S. K.; Jacobs, M. R.; Klopman, G.; Ellner, J. J. ; Orme, I. M. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions. Antimicrob. Agents Chemother. 1994, 38, 2557-2563.
20. Collins, L.; Franzblau, S. G. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob. Agents Chemother. 1997, 41, 1004-1009.