Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5′-triphosphate metabolite levels

FEBS Letters

Volumn 573, Issue 1-3, 2004, Pages 38-44

  Balzarini, Jan ^a   Aquaro, Stefano ^b   Hassan Abdallah, Alshaimaa ^c   Daluge, Susan M ^d   Perno, Carlo Federico ^b   McGuigan, Chris ^c  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d GLAXOSMITHKLINE   (United States)

Author keywords

ABC, abacavir; ABC MP, ABC 5 monophosphate; CBV, carbovir; CBV DP, CBV 5 diphosphate; CBV MP, CBV 5 monophosphate; CBV TP, CBV 5 triphosphate

Indexed keywords

5' TRIPHOSPHATE; ABACAVIR; ANTIVIRUS AGENT; CARBOVIR; DRUG METABOLITE; PRODRUG; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; ISOTOPE LABELING; LYMPHOCYTE CULTURE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

ANTI-HIV AGENTS; CELL LINE; DEOXYGUANINE NUCLEOTIDES; DIDEOXYNUCLEOSIDES; HIV-1; HUMANS; MACROPHAGES; MONOCYTES; PRODRUGS; PURINE NUCLEOTIDES;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 4344590715     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.07.049     Document Type: Article

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