Inhibition of nucleoside transport by new analogues of 4- nitrobenzylthioinosine: Replacement of the ribose moiety by substituted benzyl groups

Journal of Medicinal Chemistry

Volumn 47, Issue 22, 2004, Pages 5441-5450

  Tromp, Reynier A ^a   Van Ameijde, Susan ^a   Pütz, Claudia ^b   Sundermann, Corinna ^b   Sundermann, Bernd ^b   Von Frijtag Drabbe Künzel, Jacobien K ^a   Ijzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b GRÜNENTHAL GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 NITROBENZULSULFANYL) 9 (4' TRIFLUOROMETHYLBIPHENYL 2 YLMETHYL)PURINE; 9 (2 HYDROXYBENZYL) 6 (4 NITROBENZYLSULFANYL)PURINE; AMINE; BENZYL DERIVATIVE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; HALOGEN; HYDROXYL GROUP; LUF 5919; LUF 5929; NITRO DERIVATIVE; NITROBENZYLTHIOINOSINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RIBOSE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DRUG ABSORPTION; DRUG PENETRATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; NUCLEOSIDE TRANSPORT; SURFACE PROPERTY;

BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ERYTHROCYTE MEMBRANE; HUMANS; MODELS, MOLECULAR; NITROBENZENES; PURINES; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES;

EID: 6044232038     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049735v     Document Type: Article

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