Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2225-2230

  Gangjee, Aleem ^a   Jain, Hiteshkumar D ^a   Kisliuk, Roy L ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 OXO 5 THIOPYRIDYL 6 METHYLPYROLO[2,3 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; NOLATREXED; PEMETREXED; PYRIMIDINE DERIVATIVE; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; TRIMETREXATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; IC 50; MEDICAL ASSESSMENT; NONHUMAN; X RAY;

ESCHERICHIA COLI;

EID: 17144429703     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.029     Document Type: Article

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