Dedifferentiation of Lineage-Committed Cells by a Small Molecule

Journal of the American Chemical Society

Volumn 126, Issue 2, 2004, Pages 410-411

  Chen, Shuibing ^a   Zhang, Qisheng ^a   Wu, Xu ^a   Schultz, Peter G ^a   Ding, Sheng ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE DERIVATIVE; REVERSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL KINETICS; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; MYOBLAST; NONHUMAN; PHENOMENOLOGY; PHENOTYPE; PLASTICITY; STEM CELL; TISSUE REPAIR;

ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; MICE; MOLECULAR WEIGHT; MORPHOLINES; MYOBLASTS; OSTEOCYTES; PURINES; STEM CELLS;

EID: 0347717672     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja037390k     Document Type: Article

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13. At the effective concentration (1-10 μM), no significant cell death was observed during dedifferentiation stage. In addition, transdifferentiation of C2C12 myoblasts to osteoblasts or adipocytes was not observed under the conditions used to induce osteogenesis or adipogenesis. These observations suggest that reversine acts as a dedifferentiation-inducing agent rather than simply enriching certain type of progenitor cells by killing myoblasts.