A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

Chemistry and Biology

Volumn 8, Issue 3, 2001, Pages 289-299

  Chiosis, Gabriela ^a   Timaul, Merna N ^a   Lucas, Brian ^a   Munster, Pamela N ^a   Zheng, Fuzhong F ^a   Sepp Lorenzino, Laura ^a,b   Rosen, Neal ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Geldanamycin; Her2; Hsp90 inhibitor; Novel anti tumor agent

Indexed keywords

ADENINE NUCLEOTIDE; BENZOQUINONE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; QUINONE DERIVATIVE;

ARTICLE; BINDING COMPETITION; BREAST TUMOR; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; DRUG DESIGN; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; PATHOLOGY; PROTEIN BINDING;

ADENINE NUCLEOTIDES; BENZOQUINONES; BINDING, COMPETITIVE; BREAST NEOPLASMS; CELL CYCLE; CELL DIFFERENTIATION; DRUG DESIGN; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; PROTEIN BINDING; QUINONES; RECEPTOR, ERBB-2; TUMOR CELLS, CULTURED;

EID: 0035071607     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00015-1     Document Type: Article

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