PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP

Cellular Signalling

Volumn 14, Issue 3, 2002, Pages 277-284

  Lee, Richard ^a   Wolda, Sharon ^b   Moon, Eunyi ^a   Esselstyn, James ^b   Hertel, Carmen ^b   Lerner, Adam ^a,c  

^a BOSTON MEDICAL CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP; CLL; Cyclic nucleotide phosphodiesterases; PDE7; Theophylline

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENZYME INHIBITOR; IC 242; ISOBUTYLMETHYLXANTHINE; ISOENZYME; METHYLXANTHINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 7A; PHOSPHODIESTERASE INHIBITOR; THEOPHYLLINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL LEVEL; CELL LINE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME ISOLATION; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; B-LYMPHOCYTES; CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; HUMANS; INTRACELLULAR FLUID; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LEUKEMIA, T-CELL, ACUTE; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, PURINERGIC P1; SPLEEN; THEOPHYLLINE; TUMOR CELLS, CULTURED; UP-REGULATION; XANTHINES;

EID: 0036151438     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(01)00250-9     Document Type: Article

References (28)