Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines

Journal of Combinatorial Chemistry

Volumn 4, Issue 2, 2002, Pages 183-186

  Ding, Sheng ^a   Gray, Nathanael S ^b   Ding, Qiang ^b   Wu, Xu ^b   Schultz, Peter G ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PURINE DERIVATIVE;

ARTICLE; COMBINATORIAL CHEMISTRY; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; PURINES;

EID: 0036518392     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc010080i     Document Type: Article

References (10)

1. For 2-, 6-, 9-substituted purine analogues, please see the following examples, (a) Gray, N. S.; Wodicka, L.; Thunnissen, A.-M. W. H.; Norman, T. C.; Kwon, S.; Espinoza, F. H.; Morgan, D. O.; Barnes, G.; LeClerc, S.; Meijer, L.; Kim, S.-H.; Lockhart, D. J.; Schultz, P. G. Science 1998, 281, 533
2. (b) Chang, Y.-T.; Gray, N. S.; Chang, R. G. R.; Sutherlin, D. P.; Kwon, S.; Norman, T. C.; Sarohia, R.; Leost, M.; Meijer, L.; Schultz, P. G. Chem. Biol. 1999, 6, 361.
3. (a) McMahon, G.; Sun, L.; Liang, C.; Tang, C. Curr. Opin. Drug Discovery Dev. 1998, 1, 131.
4. (b) Adams, J. L.; Lee, D. Curr. Opin. Drug Discovery Dev. 1999, 2, 96.
5. Cohen, P. Curr. Opin. Chem. Biol. 1999, 3, 459.
6. Garcia-Echeverria, C.; Traxler, P.; Evans, D. B. Med. Res. Rev 2000, 20, 28.
7. (e) Blume-Jensen, P.; Hunter, T. Nature 2001, 411, 355 and references therein.
8. Ding, S.; Gray, N. S.; Ding, Q.; Schultz, P. G. J. Org. Chem. 2001, 66, 8273.
9. Gayo, L. M.; Suto, M. J. Tetrahedron Lett. 1997, 38, 211.
10. Johnson, C. R.; Zhang, B.; Fantauzzi, P.; Hocker, M.; Yager, K. M. Tetrahedron Lett. 1998, 54, 4097.