-
1
-
-
0345490853
-
A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease
-
Abbas N., Lucking C.B., Ricard S., Durr A., Bonifati V., De M.G., et al. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Human Molecular Genetics. 8:1999;567-574.
-
(1999)
Human Molecular Genetics
, vol.8
, pp. 567-574
-
-
Abbas, N.1
Lucking, C.B.2
Ricard, S.3
Durr, A.4
Bonifati, V.5
De, M.G.6
-
2
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.H., Castillo P.E., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 25:2000;239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
-
4
-
-
18544364794
-
Alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells
-
Ahn B.H., Rhim H., Kim S.Y., Sung Y.M., Lee M.Y., Choi J.Y., et al. alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. Journal of Biological Chemistry. 277:2002;12334-12342.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 12334-12342
-
-
Ahn, B.H.1
Rhim, H.2
Kim, S.Y.3
Sung, Y.M.4
Lee, M.Y.5
Choi, J.Y.6
-
5
-
-
0037127216
-
Tubulin seeds alpha-synuclein fibril formation
-
Alim M.A., Hossain M.S., Arima K., Takeda K., Izumiyama Y., Nakamura M., et al. Tubulin seeds alpha-synuclein fibril formation. Journal of Biological Chemistry. 277:2002;2112-2117.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 2112-2117
-
-
Alim, M.A.1
Hossain, M.S.2
Arima, K.3
Takeda, K.4
Izumiyama, Y.5
Nakamura, M.6
-
6
-
-
0036142959
-
Parkinson disease neuropathology, later-developing dementia and loss of levadopa response
-
Apaydin H., Ahlskog E., Parisi J.E., Boeve B.F., Dickson D.W. Parkinson disease neuropathology, later-developing dementia and loss of levadopa response. Archives of Neurology. 59:2002;102-112.
-
(2002)
Archives of Neurology
, vol.59
, pp. 102-112
-
-
Apaydin, H.1
Ahlskog, E.2
Parisi, J.E.3
Boeve, B.F.4
Dickson, D.W.5
-
7
-
-
0032560486
-
Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
Ara J., Przedborski S., Naini A.B., Jackson-Lewis V., Trifiletti R.R., Horwitz J., et al. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proceedings of the National Academy of Sciences of the United States of America. 95:1998;7659-7663.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 7659-7663
-
-
Ara, J.1
Przedborski, S.2
Naini, A.B.3
Jackson-Lewis, V.4
Trifiletti, R.R.5
Horwitz, J.6
-
8
-
-
0035847186
-
Alpha-Synuclein-positive structures in cases with sporadic Alzheimer's disease: Morphology and its relationship to tau aggregation
-
Arai Y., Yamazaki M., Mori O., Muramatsu H., Asano G., Katayama Y. alpha-Synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation. Brain Research. 888:2001;287-296.
-
(2001)
Brain Research
, vol.888
, pp. 287-296
-
-
Arai, Y.1
Yamazaki, M.2
Mori, O.3
Muramatsu, H.4
Asano, G.5
Katayama, Y.6
-
9
-
-
0032849237
-
Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies
-
Arima K., Hirai S., Sunohara N., Aoto K., Izumiyama Y., Ueda K., et al. Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Research. 843:1999;53-61.
-
(1999)
Brain Research
, vol.843
, pp. 53-61
-
-
Arima, K.1
Hirai, S.2
Sunohara, N.3
Aoto, K.4
Izumiyama, Y.5
Ueda, K.6
-
10
-
-
0033945604
-
NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: Double-immunolabeling fluorescence and electron microscopic studies
-
Arima K., Mizutani T., Alim M.A., Tonozuka-Uehara H., Izumiyama Y., Hirai S., et al. NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta Neuropathologica. 100:2000;115-121.
-
(2000)
Acta Neuropathologica
, vol.100
, pp. 115-121
-
-
Arima, K.1
Mizutani, T.2
Alim, M.A.3
Tonozuka-Uehara, H.4
Izumiyama, Y.5
Hirai, S.6
-
11
-
-
0036468432
-
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
-
Auluck P.K., Chan H.Y., Trojanowski J.Q., Lee V.M., Bonini N.M. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 295:2002;865-868.
-
(2002)
Science
, vol.295
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
12
-
-
0036852712
-
Pharmacological prevention of Parkinson disease in Drosophila
-
Auluck P.V., Bonini N.M. Pharmacological prevention of Parkinson disease in Drosophila. Nature Medicine. 8:2002;1185-1186.
-
(2002)
Nature Medicine
, vol.8
, pp. 1185-1186
-
-
Auluck, P.V.1
Bonini, N.M.2
-
13
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba M., Nakajo S., Tu P.H., Tomita T., Nakaya K., Lee V.M., et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. American Journal of Pathology. 152:1998;879-884.
-
(1998)
American Journal of Pathology
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
-
14
-
-
0036830228
-
The neuropathogenic contributions of lysosomal dysfunction
-
Bahr B.A., Bendiske J. The neuropathogenic contributions of lysosomal dysfunction. Journal of Neurochemistry. 83:2002;481-489.
-
(2002)
Journal of Neurochemistry
, vol.83
, pp. 481-489
-
-
Bahr, B.A.1
Bendiske, J.2
-
15
-
-
0033607801
-
Degradation of alpha-synuclein by proteasome
-
Bennett M.C., Bishop J.F., Leng Y., Chock P.B., Chase T.N., Mouradian M.M. Degradation of alpha-synuclein by proteasome. Journal of Biological Chemistry. 274:1999;33855-33858.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 33855-33858
-
-
Bennett, M.C.1
Bishop, J.F.2
Leng, Y.3
Chock, P.B.4
Chase, T.N.5
Mouradian, M.M.6
-
16
-
-
0034982293
-
Mouse models of alpha-synucleinopathy and Lewy pathology. alpha-Synuclein expression in transgenic mice
-
Barbieri S., Hofele K., Wiederhold K.H., Probst A., Mistl C., Danner S., et al. Mouse models of alpha-synucleinopathy and Lewy pathology. alpha-Synuclein expression in transgenic mice. Advances in Experimental Medicine and Biology. 487:2001;147-167.
-
(2001)
Advances in Experimental Medicine and Biology
, vol.487
, pp. 147-167
-
-
Barbieri, S.1
Hofele, K.2
Wiederhold, K.H.3
Probst, A.4
Mistl, C.5
Danner, S.6
-
17
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nature Neuroscience. 3:2000;1301-1306.
-
(2000)
Nature Neuroscience
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
18
-
-
0034602176
-
Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs
-
Biere A.L., Wood S.J., Wypych J., Steavenson S., Jiang Y., Anafi D., et al. Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs. Journal of Biological Chemistry. 275:2000;34574-34579.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 34574-34579
-
-
Biere, A.L.1
Wood, S.J.2
Wypych, J.3
Steavenson, S.4
Jiang, Y.5
Anafi, D.6
-
19
-
-
0035412944
-
Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy
-
Boeve B.F., Silber M.H., Ferman T.J., Lucas J.A., Parisi J.E. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Movement Disorder. 16:2001;622-630.
-
(2001)
Movement Disorder
, vol.16
, pp. 622-630
-
-
Boeve, B.F.1
Silber, M.H.2
Ferman, T.J.3
Lucas, J.A.4
Parisi, J.E.5
-
20
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism
-
Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism. Science. 299:2003;256-259.
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
Van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
-
21
-
-
0033083758
-
Silver staining method for demonstrating Lewy bodies in Parkinson's disease and argyrophilic oligodendrocytes in multiple system atrophy
-
Braak E., Braak H. Silver staining method for demonstrating Lewy bodies in Parkinson's disease and argyrophilic oligodendrocytes in multiple system atrophy. Journal of Neuroscience Methods. 87:1999;111-115.
-
(1999)
Journal of Neuroscience Methods
, vol.87
, pp. 111-115
-
-
Braak, E.1
Braak, H.2
-
22
-
-
0028171592
-
Amygdala pathology in Parkinson's disease
-
Braak H., Braak E., Yilmazer D., de V.R., Jansen E.N., Bohl J., et al. Amygdala pathology in Parkinson's disease. Acta Neuropathologica (Berlin). 88:1994;493-500.
-
(1994)
Acta Neuropathologica (Berlin)
, vol.88
, pp. 493-500
-
-
Braak, H.1
Braak, E.2
Yilmazer, D.3
De, V.R.4
Jansen, E.N.5
Bohl, J.6
-
23
-
-
0029414766
-
Nigral and extranigral pathology in Parkinson's disease
-
Braak H., Braak E., Yilmazer D., Schultz C., de V.R., Jansen E.N. Nigral and extranigral pathology in Parkinson's disease. Journal of Neural Transmission-Supplement. 46:1995;15-31.
-
(1995)
Journal of Neural Transmission-Supplement
, vol.46
, pp. 15-31
-
-
Braak, H.1
Braak, E.2
Yilmazer, D.3
Schultz, C.4
De, V.R.5
Jansen, E.N.6
-
24
-
-
0029940510
-
Pattern of brain destruction in Parkinson's and Alzheimer's diseases
-
Braak H., Braak E., Yilmazer D., de V.R., Jansen E.N., Bohl J. Pattern of brain destruction in Parkinson's and Alzheimer's diseases. Journal of Neural Transmission. 103:1996;455-490.
-
(1996)
Journal of Neural Transmission
, vol.103
, pp. 455-490
-
-
Braak, H.1
Braak, E.2
Yilmazer, D.3
De, V.R.4
Jansen, E.N.5
Bohl, J.6
-
25
-
-
0033538002
-
Extensive axonal Lewy neurites in Parkinson's disease: A novel pathological feature revealed by alpha-synuclein immunocytochemistry
-
Braak H., Sandmann-Keil D., Gai W., Braak E. Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry. Neuroscience Letters. 265:1999;67-69.
-
(1999)
Neuroscience Letters
, vol.265
, pp. 67-69
-
-
Braak, H.1
Sandmann-Keil, D.2
Gai, W.3
Braak, E.4
-
26
-
-
0342657004
-
Parkinson's disease: Affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system
-
Braak H., Rub U., Sandmann-Keil D., Gai W.P., de V.R., Jansen S.E., et al. Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system. Acta Neuropathologica (Berlin). 99:2000;489-495.
-
(2000)
Acta Neuropathologica (Berlin)
, vol.99
, pp. 489-495
-
-
Braak, H.1
Rub, U.2
Sandmann-Keil, D.3
Gai, W.P.4
De, V.R.5
Jansen, S.E.6
-
27
-
-
0034774011
-
Nerve cells expressing heat-shock proteins in Parkinson's disease
-
Braak H., Del Tredici T.K., Sandmann-Keil D., Rub U., Schultz C. Nerve cells expressing heat-shock proteins in Parkinson's disease. Acta Neuropathologica (Berlin). 102:2001;449-454.
-
(2001)
Acta Neuropathologica (Berlin)
, vol.102
, pp. 449-454
-
-
Braak, H.1
Del Tredici, T.K.2
Sandmann-Keil, D.3
Rub, U.4
Schultz, C.5
-
28
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H., Tredici K.D., Rub U., de Vos R.A., Jansen Steur E.N., Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiology of Aging. 24:2003;197-211.
-
(2003)
Neurobiology of Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Tredici, K.D.2
Rub, U.3
De Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
29
-
-
0028828550
-
Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5
-
Brion J.P., Couck A.M. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. American Journal of Pathology. 147:1995;1465-1476.
-
(1995)
American Journal of Pathology
, vol.147
, pp. 1465-1476
-
-
Brion, J.P.1
Couck, A.M.2
-
31
-
-
0033608811
-
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss
-
Brooks A.I., Chadwick C.A., Gelbard H.A., Cory-Slechta D.A., Federoff H.J. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Research. 823:1999;1-10.
-
(1999)
Brain Research
, vol.823
, pp. 1-10
-
-
Brooks, A.I.1
Chadwick, C.A.2
Gelbard, H.A.3
Cory-Slechta, D.A.4
Federoff, H.J.5
-
32
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
Bucciantini M., Giannoni E., Chiti F., Baroni F., Formigli L., Zurdo J., et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature. 416:2002;507-511.
-
(2002)
Nature
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
Baroni, F.4
Formigli, L.5
Zurdo, J.6
-
33
-
-
0035666667
-
Multiple system atrophy: Cellular and molecular pathology
-
Burn D.J., Jaros E. Multiple system atrophy: cellular and molecular pathology. Molecular Pathology. 54:2001;419-426.
-
(2001)
Molecular Pathology
, vol.54
, pp. 419-426
-
-
Burn, D.J.1
Jaros, E.2
-
34
-
-
0035824545
-
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein
-
Bussell R.J., Eliezer D. Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein. Journal of Biological Chemistry. 276:2001;45996-46003.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 45996-46003
-
-
Bussell, R.J.1
Eliezer, D.2
-
35
-
-
0036312497
-
Treatment of Parkinson's disease with L-DOPA. The early discovery phase, and comments on current problems
-
Carlsson A. Treatment of Parkinson's disease with L-DOPA. The early discovery phase, and comments on current problems. Journal of Neural Transmission. 109:2002;777-787.
-
(2002)
Journal of Neural Transmission
, vol.109
, pp. 777-787
-
-
Carlsson, A.1
-
36
-
-
0031200869
-
Free radicals and the pathobiology of brain dopamine systems
-
Cadet J.L., Brannock C. Free radicals and the pathobiology of brain dopamine systems. Neurochemistry International. 32:1998;117-131.
-
(1998)
Neurochemistry International
, vol.32
, pp. 117-131
-
-
Cadet, J.L.1
Brannock, C.2
-
37
-
-
0037109727
-
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein
-
Cabin D.E., Shimazu K., Murphy D., Cole N.B., Gottschalk W., McIIwain K.L., et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein. Journal of Neuroscience. 22:2002;8797-8807.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 8797-8807
-
-
Cabin, D.E.1
Shimazu, K.2
Murphy, D.3
Cole, N.B.4
Gottschalk, W.5
McIIwain, K.L.6
-
38
-
-
0038341134
-
A broken α-helix in folded α-synuclein
-
Chandra, S., Chen, X., Rizo, J., Jahn, R., Südhof, T.C. A broken α-helix in folded α-synuclein. Journal of Biological Chemistry, 278, 15313-15318.
-
Journal of Biological Chemistry
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Südhof, T.C.5
-
40
-
-
0035894661
-
Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system
-
Chiba-Falek O., Nussbaum R.L. Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. Human Molecular Genetics. 10:2001;3101-3109.
-
(2001)
Human Molecular Genetics
, vol.10
, pp. 3101-3109
-
-
Chiba-Falek, O.1
Nussbaum, R.L.2
-
41
-
-
0035903813
-
Co-association of Parkin and α-synuclein
-
Choi P., Golts N., Snyder H., Chong M., Petrucelli L., Hardy J., et al. Co-association of Parkin and α-synuclein. Neuroreport. 12:2001;2839-2843.
-
(2001)
Neuroreport
, vol.12
, pp. 2839-2843
-
-
Choi, P.1
Golts, N.2
Snyder, H.3
Chong, M.4
Petrucelli, L.5
Hardy, J.6
-
42
-
-
0034776095
-
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
-
Chung K.K., Zhang Y., Lim K.L., Tanaka Y., Huang H., Gao J., et al. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nature Medicine. 7:2001;1144-1150.
-
(2001)
Nature Medicine
, vol.7
, pp. 1144-1150
-
-
Chung, K.K.1
Zhang, Y.2
Lim, K.L.3
Tanaka, Y.4
Huang, H.5
Gao, J.6
-
44
-
-
0032102455
-
The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
Clayton D.F., George J.M. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends in Neurosciences. 21:1998;249-254.
-
(1998)
Trends in Neurosciences
, vol.21
, pp. 249-254
-
-
Clayton, D.F.1
George, J.M.2
-
45
-
-
0036364454
-
The cell biology of alpha-synuclein: A sticky problem?
-
Cole N.B., Murphy D.D. The cell biology of alpha-synuclein: a sticky problem? Neuromolecular Medicine. 1:2002;95-109.
-
(2002)
Neuromolecular Medicine
, vol.1
, pp. 95-109
-
-
Cole, N.B.1
Murphy, D.D.2
-
46
-
-
0035208654
-
Cytosolic O-glycosylation is abundant in nerve terminals
-
Cole R.N., Hart G.W. Cytosolic O-glycosylation is abundant in nerve terminals. Journal of Neurochemistry. 79:2001;1080-1089.
-
(2001)
Journal of Neurochemistry
, vol.79
, pp. 1080-1089
-
-
Cole, R.N.1
Hart, G.W.2
-
47
-
-
0036774951
-
Axon pathology in neurological disease: A neglected therapeutic target
-
Coleman M.P., Perry V.H. Axon pathology in neurological disease: a neglected therapeutic target. Trends in Neurosciences. 25:2002;532-537.
-
(2002)
Trends in Neurosciences
, vol.25
, pp. 532-537
-
-
Coleman, M.P.1
Perry, V.H.2
-
48
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway K.A., Harper J.D., Lansbury P.T. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nature Medicine. 4:1998;1318-1320.
-
(1998)
Nature Medicine
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
49
-
-
0034646391
-
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
-
Conway K.A., Harper J.D., Lansbury P.T.J. Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry. 39:2000a;2552-2563.
-
(2000)
Biochemistry
, vol.39
, pp. 2552-2563
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.J.3
-
50
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway K.A., Lee S.J., Rochet J.C., Ding T.T., Williamson R.E., Lansbury P.T.J. Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proceedings of the National Academy of Sciences of the United States of America. 97:2000b;571-576.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.J.6
-
51
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
Conway K.A., Rochet J.C., Bieganski R.M., Lansbury P.T.J. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science. 294:2001;1346-1349.
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury, P.T.J.4
-
52
-
-
0037426917
-
Pathways to parkinsonism
-
Cookson M.R. Pathways to parkinsonism. Neuron. 37:2003;7-10.
-
(2003)
Neuron
, vol.37
, pp. 7-10
-
-
Cookson, M.R.1
-
53
-
-
0035705226
-
A candidate gene for human neurodegenerative disorders: A rat PKC gamma mutation causes a Parkinsonian syndrome
-
Craig N.J., Duran A.M., Hawker K.L., Shiels P., Glencorse T.A., Campbell J.M., et al. A candidate gene for human neurodegenerative disorders: a rat PKC gamma mutation causes a Parkinsonian syndrome. Nature Neuroscience. 4:2001;1061-1062.
-
(2001)
Nature Neuroscience
, vol.4
, pp. 1061-1062
-
-
Craig, N.J.1
Duran, A.M.2
Hawker, K.L.3
Shiels, P.4
Glencorse, T.A.5
Campbell, J.M.6
-
54
-
-
0031728689
-
Synthetic filaments assembled from C-terminally truncated alpha-synuclein
-
Crowther R.A., Jakes R., Spillantini M.G., Goedert M. Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Letters. 436:1998;309-312.
-
(1998)
FEBS Letters
, vol.436
, pp. 309-312
-
-
Crowther, R.A.1
Jakes, R.2
Spillantini, M.G.3
Goedert, M.4
-
55
-
-
0032589409
-
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid
-
Culvenor J.G., McLean C.A., Cutt S., Campbell B.C., Maher F., Jakala P., et al. Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid. American Journal of Pathology. 155:1999;1173-1181.
-
(1999)
American Journal of Pathology
, vol.155
, pp. 1173-1181
-
-
Culvenor, J.G.1
McLean, C.A.2
Cutt, S.3
Campbell, B.C.4
Maher, F.5
Jakala, P.6
-
56
-
-
0034604583
-
Wild-type but not Parkinson's disease-related ala-53 - > Thr mutant alpha-synuclein protects neuronal cells from apoptotic stimuli
-
Da Costa C.A., Ancolio K., Checler F. Wild-type but not Parkinson's disease-related ala-53 - > Thr mutant alpha-synuclein protects neuronal cells from apoptotic stimuli. Journal of Biological Chemistry. 275:2000;24065-24069.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 24065-24069
-
-
Da Costa, C.A.1
Ancolio, K.2
Checler, F.3
-
57
-
-
0037185004
-
Alpha-Synuclein lowers p53-dependent apoptotic response in neuronal cells: Abolishment by 6-hydroxydopamine and implication for Parkinson's disease
-
Da Costa C.A., Paitel E., Vincent B., Checler F. alpha-Synuclein lowers p53-dependent apoptotic response in neuronal cells: abolishment by 6-hydroxydopamine and implication for Parkinson's disease. Journal of Biological Chemistry. 277:2002;50980-50984.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 50980-50984
-
-
Da Costa, C.A.1
Paitel, E.2
Vincent, B.3
Checler, F.4
-
58
-
-
0037195109
-
Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP
-
Dauer W.T., Kholodilov N.G., Vila M., Trillat A.-C., Goodchild R., Larsen K.E., et al. Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America. 99:2002;14524-14529.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 14524-14529
-
-
Dauer, W.T.1
Kholodilov, N.G.2
Vila, M.3
Trillat, A.-C.4
Goodchild, R.5
Larsen, K.E.6
-
60
-
-
0036094576
-
Where does Parkinson disease begin in the brain
-
Del Tredici K., Rueb U., de Vos R.A.I., Bohl J.R.E., Braak H. Where does Parkinson disease begin in the brain. Journal of Neuropathology and Experimental Neurology. 61:2002;413-426.
-
(2002)
Journal of Neuropathology and Experimental Neurology
, vol.61
, pp. 413-426
-
-
Del Tredici, K.1
Rueb, U.2
De Vos, R.A.I.3
Bohl, J.R.E.4
Braak, H.5
-
61
-
-
0027459039
-
The audiospinal reaction in Parkinsonian patients reflects functional changes in reticular nuclei
-
Delwaide P.J., Pepin J.L., Maertens D.N. The audiospinal reaction in Parkinsonian patients reflects functional changes in reticular nuclei. Annals of Neurology. 33:1993;63-69.
-
(1993)
Annals of Neurology
, vol.33
, pp. 63-69
-
-
Delwaide, P.J.1
Pepin, J.L.2
Maertens, D.N.3
-
62
-
-
57849084804
-
The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans
-
Den Hartog W.A., Bethlem J. The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. Journal of Neurology Neurosurgery and Psychiatry. 23:1960;283-290.
-
(1960)
Journal of Neurology Neurosurgery and Psychiatry
, vol.23
, pp. 283-290
-
-
Den Hartog, W.A.1
Bethlem, J.2
-
63
-
-
0038724238
-
Part I: Parkin-associated proteins and Parkinson's disease
-
PII:S0028-3908(02)00337-4
-
Dev, K.K., van der Putten, H., Sommer, B., Rovelli, G., 2003. Part I: Parkin-associated proteins and Parkinson's disease. Neuropharmacology 45, this issue. PII:S0028-3908(02)00337-4.
-
(2003)
Neuropharmacology
, vol.45
, Issue.THIS ISSUE
-
-
Dev, K.K.1
Van Der Putten, H.2
Sommer, B.3
Rovelli, G.4
-
65
-
-
84940364788
-
Alpha-Synuclein and the Lewy body disorders
-
Dickson D.W. alpha-Synuclein and the Lewy body disorders. Current Opinions in Neurology. 14:2001;423-432.
-
(2001)
Current Opinions in Neurology
, vol.14
, pp. 423-432
-
-
Dickson, D.W.1
-
66
-
-
0037072284
-
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
-
Ding T.T., Lee S.J., Rochet J.C., Lansbury P.T.J. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry. 41:2002;10209-10217.
-
(2002)
Biochemistry
, vol.41
, pp. 10209-10217
-
-
Ding, T.T.1
Lee, S.J.2
Rochet, J.C.3
Lansbury, P.T.J.4
-
67
-
-
0030778385
-
Neurobiology of retinal dopamine in relation to degenerative states of the tissue
-
Djamgoz M.B., Hankins M.W., Hirano J., Archer S.N. Neurobiology of retinal dopamine in relation to degenerative states of the tissue. Vision Research. 37:1997;3509-3529.
-
(1997)
Vision Research
, vol.37
, pp. 3509-3529
-
-
Djamgoz, M.B.1
Hankins, M.W.2
Hirano, J.3
Archer, S.N.4
-
68
-
-
18344365954
-
Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form
-
Doskeland A.P., Flatmark T. Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form. European Journal of Biochemistry. 269:2002;1561-1569.
-
(2002)
European Journal of Biochemistry
, vol.269
, pp. 1561-1569
-
-
Doskeland, A.P.1
Flatmark, T.2
-
69
-
-
0036787779
-
Overexpression of Parkinson's disease-associated alpha-synuclein A53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP
-
Dong Z., Ferger B., Feldon J., Bueler H. Overexpression of Parkinson's disease-associated alpha-synuclein A53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP. Journal of Neurobiology. 53:2002;1-10.
-
(2002)
Journal of Neurobiology
, vol.53
, pp. 1-10
-
-
Dong, Z.1
Ferger, B.2
Feldon, J.3
Bueler, H.4
-
70
-
-
0037457966
-
Chaperones increase association of tau protein with microtubules
-
Dou F., Netzer W.J., Tanemura K., Li F., Hartl U., Takashima A., et al. Chaperones increase association of tau protein with microtubules. Proceedings of the National Academy of Sciences of the United States of America. 100:2003;721-726.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 721-726
-
-
Dou, F.1
Netzer, W.J.2
Tanemura, K.3
Li, F.4
Hartl, U.5
Takashima, A.6
-
71
-
-
0033678217
-
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies
-
Duda J.E., Giasson B.I., Chen Q., Gur T.L., Hurtig H.I., Stern M.B., et al. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. American Journal of Pathology. 157:2000;1439-1445.
-
(2000)
American Journal of Pathology
, vol.157
, pp. 1439-1445
-
-
Duda, J.E.1
Giasson, B.I.2
Chen, Q.3
Gur, T.L.4
Hurtig, H.I.5
Stern, M.B.6
-
72
-
-
0036934244
-
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred
-
Duda J.E., Giasson B.I., Mabon M.E., Miller D.C., Golbe L.I., Lee V.M., et al. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathologica (Berlin). 104:2002a;7-11.
-
(2002)
Acta Neuropathologica (Berlin)
, vol.104
, pp. 7-11
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Miller, D.C.4
Golbe, L.I.5
Lee, V.M.6
-
73
-
-
0036322266
-
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
-
Duda J.E., Giasson B.I., Mabon M.E., Miller D.C., Golbe L.I., Lee V.M., et al. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of Neurology. 52:2002b;205-210.
-
(2002)
Annals of Neurology
, vol.52
, pp. 205-210
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Miller, D.C.4
Golbe, L.I.5
Lee, V.M.6
-
74
-
-
0036025165
-
Depression and Parkinson's disease: A new look at an old probem
-
Edwards E., Kitt C., Olives E., Finkelstein J., Wagster M., McDonald W.M. Depression and Parkinson's disease: a new look at an old probem. Depression Anxiety. 16:2002;39-48.
-
(2002)
Depression Anxiety
, vol.16
, pp. 39-48
-
-
Edwards, E.1
Kitt, C.2
Olives, E.3
Finkelstein, J.4
Wagster, M.5
McDonald, W.M.6
-
75
-
-
0032992466
-
Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: A nitric oxide-dependent mechanism of cellular injury
-
Eiserich J.P., Estevez A.G., Bamberg T.V., Ye Y.Z., Chumley P.H., Beckman J.S., et al. Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. Proceedings of the National Academy of Sciences of the United States of America. 96:1999;6365-6370.
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, pp. 6365-6370
-
-
Eiserich, J.P.1
Estevez, A.G.2
Bamberg, T.V.3
Ye, Y.Z.4
Chumley, P.H.5
Beckman, J.S.6
-
76
-
-
0032573289
-
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease
-
El-Agnaf O.M., Jakes R., Curran M.D., Wallace A. Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Letters. 440:1998;67-70.
-
(1998)
FEBS Letters
, vol.440
, pp. 67-70
-
-
El-Agnaf, O.M.1
Jakes, R.2
Curran, M.D.3
Wallace, A.4
-
77
-
-
0033850190
-
Review: Formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins
-
El-Agnaf O.M., Irvine G.B. Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins. Journal of Structural Biology. 130:2000;300-309.
-
(2000)
Journal of Structural Biology
, vol.130
, pp. 300-309
-
-
El-Agnaf, O.M.1
Irvine, G.B.2
-
78
-
-
0036670712
-
Aggregation and neurotoxicity of α-synuclein and related peptides
-
El-Agnaf O.M.A., Irvine G.B. Aggregation and neurotoxicity of α-synuclein and related peptides. Biochemical Society Transactions. 30:2002;559-565.
-
(2002)
Biochemical Society Transactions
, vol.30
, pp. 559-565
-
-
El-Agnaf, O.M.A.1
Irvine, G.B.2
-
79
-
-
0035815115
-
Conformational properties of alpha-synuclein in its free and lipid-associated states
-
Eliezer D., Kutluay E., Bussell R., Browne G. Conformational properties of alpha-synuclein in its free and lipid-associated states. Journal of Molecular Biology. 307:2001;1061-1073.
-
(2001)
Journal of Molecular Biology
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Bussell, R.3
Browne, G.4
-
80
-
-
0036014117
-
Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase
-
Elkon H., Don J., Melamed E., Ziv I., Shirvan A., Offen D. Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase. Journal of Molecular Neuroscience. 18:2002;229-238.
-
(2002)
Journal of Molecular Neuroscience
, vol.18
, pp. 229-238
-
-
Elkon, H.1
Don, J.2
Melamed, E.3
Ziv, I.4
Shirvan, A.5
Offen, D.6
-
81
-
-
0035830913
-
Alpha-Synuclein is phosphorylated by members of the Src family of protein tyrosine kinases
-
Ellis C.E., Schwartzberg P.L., Grider T.L., Fink D.W., Nussbaum R.L. alpha-Synuclein is phosphorylated by members of the Src family of protein tyrosine kinases. Journal of Biological Chemistry. 276:2001;3879-3894.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 3879-3894
-
-
Ellis, C.E.1
Schwartzberg, P.L.2
Grider, T.L.3
Fink, D.W.4
Nussbaum, R.L.5
-
82
-
-
0032952414
-
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
-
Engelender S., Kaminsky Z., Guo X., Sharp A.H., Amaravi R.K., Kleiderlein J.J., et al. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nature Genetics. 22:1999;110-114.
-
(1999)
Nature Genetics
, vol.22
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Guo, X.3
Sharp, A.H.4
Amaravi, R.K.5
Kleiderlein, J.J.6
-
83
-
-
0035964795
-
Dendrodendritic inhibition through reversal of dopamine transport
-
Falkenburger B.H., Barstow K.L., Mintz I.M. Dendrodendritic inhibition through reversal of dopamine transport. Science. 293:2001;2465-2470.
-
(2001)
Science
, vol.293
, pp. 2465-2470
-
-
Falkenburger, B.H.1
Barstow, K.L.2
Mintz, I.M.3
-
85
-
-
0035880458
-
Alpha-Synuclein gene haplotypes are associated with Parkinson's disease
-
Farrer M., Maraganore D.M., Lockhart P., Singleton A., Lesnick T.G., de A.M., et al. alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Human Molecular Genetics. 10:(17):2001a;1847-1851.
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.17
, pp. 1847-1851
-
-
Farrer, M.1
Maraganore, D.M.2
Lockhart, P.3
Singleton, A.4
Lesnick, T.G.5
De, A.M.6
-
86
-
-
0034848395
-
Lewy bodies and Parkinsonism in families with parkin mutations
-
Farrer M., Chan P., Chen R., Tan L., Lincoln S., Hernandez D., et al. Lewy bodies and Parkinsonism in families with parkin mutations. Annals of Neurology. 50:2001b;293-300.
-
(2001)
Annals of Neurology
, vol.50
, pp. 293-300
-
-
Farrer, M.1
Chan, P.2
Chen, R.3
Tan, L.4
Lincoln, S.5
Hernandez, D.6
-
88
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
(See comments)
-
Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature. 404:2000;394-398. (See comments).
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
89
-
-
0036092271
-
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam
-
Forman M.S., Schmidt M.L., Kasturi S., Perl D.P., Lee V.M., Trojanowski J.Q. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. American Journal of Pathology. 160:2002;1725-1731.
-
(2002)
American Journal of Pathology
, vol.160
, pp. 1725-1731
-
-
Forman, M.S.1
Schmidt, M.L.2
Kasturi, S.3
Perl, D.P.4
Lee, V.M.5
Trojanowski, J.Q.6
-
91
-
-
0036174010
-
Alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M.S., et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology. 4:2002;160-164.
-
(2002)
Nature Cell Biology
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
-
92
-
-
0029611219
-
Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease
-
Gai W.P., Blessing W.W., Blumbergs P.C. Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease. Brain. 118:(Pt.6):1995;1447-1459.
-
(1995)
Brain
, vol.118
, Issue.PART 6
, pp. 1447-1459
-
-
Gai, W.P.1
Blessing, W.W.2
Blumbergs, P.C.3
-
93
-
-
0036150971
-
The synucleins
-
George J.M. The synucleins. Genome Biology. 3:2001;3002.
-
(2001)
Genome Biology
, vol.3
, pp. 3002
-
-
George, J.M.1
-
95
-
-
0031727163
-
Genetics of Parkinson's disease
-
Gasser T. Genetics of Parkinson's disease. Clinical Genetics. 54:1998;259-265.
-
(1998)
Clinical Genetics
, vol.54
, pp. 259-265
-
-
Gasser, T.1
-
96
-
-
0037070216
-
Structure and functional properties of the ubiquitin binding protein p62
-
Geetha T., Wooten M.W. Structure and functional properties of the ubiquitin binding protein p62. FEBS Letters. 512:2002;19-24.
-
(2002)
FEBS Letters
, vol.512
, pp. 19-24
-
-
Geetha, T.1
Wooten, M.W.2
-
97
-
-
0033788434
-
Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
-
Ghee M., Fournier A., Mallet J. Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. Journal of Neurochemistry. 75:2000;2221-2224.
-
(2000)
Journal of Neurochemistry
, vol.75
, pp. 2221-2224
-
-
Ghee, M.1
Fournier, A.2
Mallet, J.3
-
98
-
-
0033583215
-
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro
-
Giasson B.I., Uryu K., Trojanowski J.Q., Lee V.M. Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. Journal of Biological Chemistry. 274:1999;7619-7622.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 7619-7622
-
-
Giasson, B.I.1
Uryu, K.2
Trojanowski, J.Q.3
Lee, V.M.4
-
99
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
-
Giasson B.I., Duda J.E., Murray I.V., Chen Q., Souza J.M., Hurtig H.I., et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science. 290:2000a;985-989.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
-
100
-
-
0034651575
-
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
-
Giasson B.I., Jakes R., Goedert M., Duda J.E., Leight S., Trojanowski J.Q., et al. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. Journal of Neuroscience Research. 59:2000b;528-533.
-
(2000)
Journal of Neuroscience Research
, vol.59
, pp. 528-533
-
-
Giasson, B.I.1
Jakes, R.2
Goedert, M.3
Duda, J.E.4
Leight, S.5
Trojanowski, J.Q.6
-
101
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
Giasson B.I., Murray I.V., Trojanowski J.Q., Lee V.M. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. Journal of Biological Chemistry. 276:2001;2380-2386.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
Lee, V.M.4
-
102
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
Giasson B.I., Duda J.E., Quinn S.M., Zhang B., Trojanowski J.Q., Lee V.M. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 34:2002;521-533.
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
Duda, J.E.2
Quinn, S.M.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
103
-
-
0035370261
-
The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases
-
Goedert M. The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases. Current Opinion in Genetics and Development. 11:2001a;343-351.
-
(2001)
Current Opinion in Genetics and Development
, vol.11
, pp. 343-351
-
-
Goedert, M.1
-
104
-
-
0035409575
-
Alpha-Synuclein and neurodegenerative diseases
-
Goedert M. alpha-Synuclein and neurodegenerative diseases. Nature Reviews Neuroscience. 2:2001b;492-501.
-
(2001)
Nature Reviews Neuroscience
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
105
-
-
0035353746
-
The tau A0 allele in Parkinson's disease
-
Golbe L.I., Ezquerra M., Spychala J.R., Johnson W.G., Stenroos E.S., Mark M.H., et al. The tau A0 allele in Parkinson's disease. Movement Disorder. 16:2001;442-447.
-
(2001)
Movement Disorder
, vol.16
, pp. 442-447
-
-
Golbe, L.I.1
Ezquerra, M.2
Spychala, J.R.3
Johnson, W.G.4
Stenroos, E.S.5
Mark, M.H.6
-
106
-
-
0033771793
-
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?
-
Goldberg M.S., Lansbury J.P. Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? Nature Cell Biology. 2:2000;E115-E119.
-
(2000)
Nature Cell Biology
, vol.2
-
-
Goldberg, M.S.1
Lansbury, J.P.2
-
107
-
-
0034609583
-
Cardiac sympathetic denervation in Parkinson disease
-
Goldstein D.S., Holmes C., Li S.T., Bruce S., Metman L.V., Cannon R.O. Cardiac sympathetic denervation in Parkinson disease. Annals of Internal Medicine. 133:2000;338-347.
-
(2000)
Annals of Internal Medicine
, vol.133
, pp. 338-347
-
-
Goldstein, D.S.1
Holmes, C.2
Li, S.T.3
Bruce, S.4
Metman, L.V.5
Cannon, R.O.6
-
108
-
-
0037333642
-
Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice
-
Gomez-Isla T., Irizarry M.C., Mariash A., Chueng B., Soto O., Schrump S., et al. Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiology of Aging. 24:2003;245-258.
-
(2003)
Neurobiology of Aging
, vol.24
, pp. 245-258
-
-
Gomez-Isla, T.1
Irizarry, M.C.2
Mariash, A.3
Chueng, B.4
Soto, O.5
Schrump, S.6
-
110
-
-
0002677297
-
Clinical and neuropathological correlates of dementia with Lewy bodies
-
Molecular Genetics of Dementia. Cambridge, MA, USA Anonymous
-
Gomez-Tortosa, E., Irizarry, M.C., Gómez-Isla, T., 2000a. Clinical and neuropathological correlates of dementia with Lewy bodies. In: Molecular Genetics of Dementia. Proceedings of the Ninth Meeting of the International Study Group on the Pharmacology of Memory Disorders associated with aging. Cambridge, MA, USA, pp. 17-23 (Anonymous).
-
(2000)
Proceedings of the Ninth Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging
, pp. 17-23
-
-
Gomez-Tortosa, E.1
Irizarry, M.C.2
Gómez-Isla, T.3
-
111
-
-
0343527226
-
Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
-
Gomez-Tortosa E., Newell K., Irizarry M.C., Sanders J.L., Hyman B.T. alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathologica (Berlin). 99:2000b;352-357.
-
(2000)
Acta Neuropathologica (Berlin)
, vol.99
, pp. 352-357
-
-
Gomez-Tortosa, E.1
Newell, K.2
Irizarry, M.C.3
Sanders, J.L.4
Hyman, B.T.5
-
112
-
-
0036943010
-
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration
-
Gomez-Tortosa E., Gonzalo I., Newell K., Yebenes G., Vonsattel P., Hyman B.T. Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration. Acta Neuropathologica (Berlin). 103:2002;495-500.
-
(2002)
Acta Neuropathologica (Berlin)
, vol.103
, pp. 495-500
-
-
Gomez-Tortosa, E.1
Gonzalo, I.2
Newell, K.3
Yebenes, G.4
Vonsattel, P.5
Hyman, B.T.6
-
113
-
-
0037073748
-
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion
-
Gosavi N., Lee H.J., Lee J.S., Patel S., Lee S.J. Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. Journal of Biological Chemistry. 277:2002;48984-48992.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 48984-48992
-
-
Gosavi, N.1
Lee, H.J.2
Lee, J.S.3
Patel, S.4
Lee, S.J.5
-
114
-
-
0027092647
-
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
-
Grant S.G., O'Dell T.J., Karl K.A., Stein P.L., Soriano P., Kandel E.R. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science. 258:1992;1903-1910.
-
(1992)
Science
, vol.258
, pp. 1903-1910
-
-
Grant, S.G.1
O'Dell, T.J.2
Karl, K.A.3
Stein, P.L.4
Soriano, P.5
Kandel, E.R.6
-
115
-
-
0037069269
-
Cognitive impairments in advanced PD without dementia
-
Green J., McDonald W.M., Vitek J.L., Evatt M., Freeman A., Haber M., Bakay R.A., Triche S., Sirockman B., De Long M.R. Cognitive impairments in advanced PD without dementia. Neurology. 59:2002;1320-1324.
-
(2002)
Neurology
, vol.59
, pp. 1320-1324
-
-
Green, J.1
McDonald, W.M.2
Vitek, J.L.3
Evatt, M.4
Freeman, A.5
Haber, M.6
Bakay, R.A.7
Triche, S.8
Sirockman, B.9
De Long, M.R.10
-
117
-
-
0030847355
-
Protein tyrosine phosphorylation: Implications for synaptic function
-
Gurd J.W. Protein tyrosine phosphorylation: implications for synaptic function. Neurochemistry International. 31:1997;635-649.
-
(1997)
Neurochemistry International
, vol.31
, pp. 635-649
-
-
Gurd, J.W.1
-
118
-
-
0034711720
-
A kindred with Parkinson's disease not showing genetic linkage to established loci
-
Gwinn-Hardy K.A., Crook R., Lincoln S., Adler C.H., Caviness J.N., Hardy J., et al. A kindred with Parkinson's disease not showing genetic linkage to established loci. Neurology. 54:2000;504-507.
-
(2000)
Neurology
, vol.54
, pp. 504-507
-
-
Gwinn-Hardy, K.A.1
Crook, R.2
Lincoln, S.3
Adler, C.H.4
Caviness, J.N.5
Hardy, J.6
-
119
-
-
0036654314
-
Genetics of Parkinsonism
-
Gwinn-Hardy K. Genetics of Parkinsonism. Movement Disorder. 17:2002;645-656.
-
(2002)
Movement Disorder
, vol.17
, pp. 645-656
-
-
Gwinn-Hardy, K.1
-
120
-
-
84950170900
-
Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease
-
Halliday G.M., Li Y.W., Blumbergs P.C., Joh T.H., Cotton R.G., Howe P.R., et al. Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease. Annals of Neurology. 27:1990;373-385.
-
(1990)
Annals of Neurology
, vol.27
, pp. 373-385
-
-
Halliday, G.M.1
Li, Y.W.2
Blumbergs, P.C.3
Joh, T.H.4
Cotton, R.G.5
Howe, P.R.6
-
121
-
-
0033919992
-
Lewy bodies in Alzheimer's disease: A neuropathological review of 145 cases using alpha-synuclein immunohistochemistry
-
Hamilton R.L. Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathology. 10:2000;378-384.
-
(2000)
Brain Pathology
, vol.10
, pp. 378-384
-
-
Hamilton, R.L.1
-
122
-
-
0029257497
-
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: Is NAC a common trigger or target in neurodegenerative disease?
-
Han H., Weinreb P.H., Lansbury P.T.J. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chemistry and Biology. 2:1995;163-169.
-
(1995)
Chemistry and Biology
, vol.2
, pp. 163-169
-
-
Han, H.1
Weinreb, P.H.2
Lansbury, P.T.J.3
-
123
-
-
0036844873
-
Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease
-
Harding A.J., Stimson E., Henderson J.M., Halliday G.M. Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease. Brain. 125:2002;2431-2445.
-
(2002)
Brain
, vol.125
, pp. 2431-2445
-
-
Harding, A.J.1
Stimson, E.2
Henderson, J.M.3
Halliday, G.M.4
-
124
-
-
0032701883
-
Neurodegenerative disease: A different view of diagnosis
-
Hardy J., Gwinn-Hardy K. Neurodegenerative disease: a different view of diagnosis. Molecular Medicine Today. 5:1999;514-517.
-
(1999)
Molecular Medicine Today
, vol.5
, pp. 514-517
-
-
Hardy, J.1
Gwinn-Hardy, K.2
-
125
-
-
0030614627
-
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
-
Harper J.D., Wong S.S., Lieber C.M., Lansbury P.T. Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chemistry and Biology. 4:1997a;119-125.
-
(1997)
Chemistry and Biology
, vol.4
, pp. 119-125
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.4
-
126
-
-
0031444010
-
Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein
-
Harper J.D., Lieber C.M., Lansbury P.T.J. Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein. Chemistry and Biology. 4:1997b;951-959.
-
(1997)
Chemistry and Biology
, vol.4
, pp. 951-959
-
-
Harper, J.D.1
Lieber, C.M.2
Lansbury, P.T.J.3
-
127
-
-
0033551440
-
Assembly of A beta amyloid protofibrils: An in vitro model for a possible early event in Alzheimer's disease
-
Harper J.D., Wong S.S., Lieber C.M., Lansbury P.T.J. Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry. 38:1999;8972-8980.
-
(1999)
Biochemistry
, vol.38
, pp. 8972-8980
-
-
Harper, J.D.1
Wong, S.S.2
Lieber, C.M.3
Lansbury, P.T.J.4
-
128
-
-
2242472974
-
Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions
-
Hasegawa M., Fujiwara H., Nonaka T., Wakabayashi K., Takahashi H., Lee V.M.-Y., et al. Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. Journal of Biological Chemistry. 277:2002;49071-49076.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 49071-49076
-
-
Hasegawa, M.1
Fujiwara, H.2
Nonaka, T.3
Wakabayashi, K.4
Takahashi, H.5
Lee, V.M.-Y.6
-
129
-
-
0032551656
-
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
-
Hashimoto M., Hsu L.J., Sisk A., Xia Y., Takeda A., Sundsmo M., et al. Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Brain Research. 799:1998;301-306.
-
(1998)
Brain Research
, vol.799
, pp. 301-306
-
-
Hashimoto, M.1
Hsu, L.J.2
Sisk, A.3
Xia, Y.4
Takeda, A.5
Sundsmo, M.6
-
130
-
-
0031589539
-
NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation
-
Hashimoto M., Yoshimoto M., Sisk A., Hsu L.J., Sundsmo M., Kittel A., et al. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. Biochemical and Biophysical Research Communications. 237:1997;611-616.
-
(1997)
Biochemical and Biophysical Research Communications
, vol.237
, pp. 611-616
-
-
Hashimoto, M.1
Yoshimoto, M.2
Sisk, A.3
Hsu, L.J.4
Sundsmo, M.5
Kittel, A.6
-
131
-
-
0032879452
-
Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease
-
Hashimoto M., Takeda A., Hsu L.J., Takenouchi T., Masliah E. Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease. Journal of Biological Chemistry. 274:1999;28849-28852.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 28849-28852
-
-
Hashimoto, M.1
Takeda, A.2
Hsu, L.J.3
Takenouchi, T.4
Masliah, E.5
-
132
-
-
0035950270
-
Masliah, E., beta-Synuclein inhibits alpha-synuclein aggregation: A possible role as an anti-parkinsonian factor
-
Hashimoto M., Rockenstein E., Mante M., Mallory M., Masliah E. Masliah, E., beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. Neuron. 32:2001;213-223.
-
(2001)
Neuron
, vol.32
, pp. 213-223
-
-
Hashimoto, M.1
Rockenstein, E.2
Mante, M.3
Mallory, M.4
Masliah, E.5
-
133
-
-
0037192865
-
Alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells
-
Hashimoto M., Hsu L.J., Rockenstein E., Takenouchi T., Mallory M., Masliah E. alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. Journal of Biological Chemistry. 277:2002;11465-11472.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 11465-11472
-
-
Hashimoto, M.1
Hsu, L.J.2
Rockenstein, E.3
Takenouchi, T.4
Mallory, M.5
Masliah, E.6
-
134
-
-
0035293622
-
Protein regulation by monoubiquitin
-
Hicke L. Protein regulation by monoubiquitin. Nature Reviews Neuroscience. 2:2002;195-201.
-
(2002)
Nature Reviews Neuroscience
, vol.2
, pp. 195-201
-
-
Hicke, L.1
-
137
-
-
0033890821
-
Alpha-synuclein promotes mitochondrial deficit and oxidative stress
-
Hsu L.J., Sagara Y., Arroyo A., Rockenstein E., Sisk A., Mallory M., et al. alpha-synuclein promotes mitochondrial deficit and oxidative stress. American Journal of Pathology. 157:2000;401-410.
-
(2000)
American Journal of Pathology
, vol.157
, pp. 401-410
-
-
Hsu, L.J.1
Sagara, Y.2
Arroyo, A.3
Rockenstein, E.4
Sisk, A.5
Mallory, M.6
-
138
-
-
0038342507
-
Association of the cytoskeletal GTP-binding protein Sept 4/5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies
-
in press
-
Ihara, M., Tomimoto, H., Katiyama, H., Morioka, Y., Akiguchi, I., Shibasaki, H., Noda, M., Kinoshita, M., 2003. Association of the cytoskeletal GTP-binding protein Sept 4/5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies. Journal of Biological Chemistry, in press.
-
(2003)
Journal of Biological Chemistry
-
-
Ihara, M.1
Tomimoto, H.2
Katiyama, H.3
Morioka, Y.4
Akiguchi, I.5
Shibasaki, H.6
Noda, M.7
Kinoshita, M.8
-
139
-
-
0030830270
-
Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly
-
Ii K., Ito H., Tanaka K., Hirano A. Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly. Journal of Neuropathology and Experimental Neurology. 56:1997;125-131.
-
(1997)
Journal of Neuropathology and Experimental Neurology
, vol.56
, pp. 125-131
-
-
Ii, K.1
Ito, H.2
Tanaka, K.3
Hirano, A.4
-
141
-
-
0031925215
-
Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome?
-
Ince P.G., Perry E.K., Morris C.M. Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome? Brain Pathology. 8:1998;299-324.
-
(1998)
Brain Pathology
, vol.8
, pp. 299-324
-
-
Ince, P.G.1
Perry, E.K.2
Morris, C.M.3
-
142
-
-
0036784803
-
Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons
-
Ingram S.L., Prasad B.M., Amara S.G. Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nature Neuroscience. 5:2002;971-978.
-
(2002)
Nature Neuroscience
, vol.5
, pp. 971-978
-
-
Ingram, S.L.1
Prasad, B.M.2
Amara, S.G.3
-
143
-
-
0031944830
-
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity
-
Irizarry M.C., Growdon W., Gomez-Isla T., Newell K., George J.M., Clayton D.F., et al. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. Journal of Neuropathology and Experimental Neurology. 57:1998;334-337.
-
(1998)
Journal of Neuropathology and Experimental Neurology
, vol.57
, pp. 334-337
-
-
Irizarry, M.C.1
Growdon, W.2
Gomez-Isla, T.3
Newell, K.4
George, J.M.5
Clayton, D.F.6
-
144
-
-
0033537922
-
Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease
-
Iseki E., Marui W., Kosaka K., Ueda K. Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease. Neuroscience Letters. 265:1999;9-12.
-
(1999)
Neuroscience Letters
, vol.265
, pp. 9-12
-
-
Iseki, E.1
Marui, W.2
Kosaka, K.3
Ueda, K.4
-
145
-
-
0031702640
-
Clinical and neuropathological aspects of autosomal recessive juvenile arkinsonism
-
Ishikawa A., Takahashi H. Clinical and neuropathological aspects of autosomal recessive juvenile arkinsonism. Journal of Neurology. 245:1998;4-9.
-
(1998)
Journal of Neurology
, vol.245
, pp. 4-9
-
-
Ishikawa, A.1
Takahashi, H.2
-
146
-
-
0034904491
-
Human immunodeficiency virus type 1 Tat binding protein-1 is a transcriptional coactivator specific for TR
-
Ishizuka T., Satoh T., Monden T., Shibusawa N., Hashida T., Yamada M., et al. Human immunodeficiency virus type 1 Tat binding protein-1 is a transcriptional coactivator specific for TR. Molecular Endocrinology. 15:2001;1329-1343.
-
(2001)
Molecular Endocrinology
, vol.15
, pp. 1329-1343
-
-
Ishizuka, T.1
Satoh, T.2
Monden, T.3
Shibusawa, N.4
Hashida, T.5
Yamada, M.6
-
147
-
-
0032926674
-
Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases
-
Iwanaga K., Wakabayashi K., Yoshimoto M., Tomita I., Satoh H., Takashima H., et al. Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases. Neurology. 52:1999;1269-1271.
-
(1999)
Neurology
, vol.52
, pp. 1269-1271
-
-
Iwanaga, K.1
Wakabayashi, K.2
Yoshimoto, M.3
Tomita, I.4
Satoh, H.5
Takashima, H.6
-
148
-
-
0035076647
-
Alpha-Synuclein forms a complex with transcription factor Elk-1
-
Iwata A., Miura S., Kanazawa I., Sawada M., Nukina N. alpha-Synuclein forms a complex with transcription factor Elk-1. Journal of Neurochemistry. 77:2001a;239-252.
-
(2001)
Journal of Neurochemistry
, vol.77
, pp. 239-252
-
-
Iwata, A.1
Miura, S.2
Kanazawa, I.3
Sawada, M.4
Nukina, N.5
-
150
-
-
0035831303
-
Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan
-
Izumi Y., Morino H., Oda M., Maruyama H., Udaka F., Kameyama M., et al. Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan. Neuroscience Letters. 300:2001;125-127.
-
(2001)
Neuroscience Letters
, vol.300
, pp. 125-127
-
-
Izumi, Y.1
Morino, H.2
Oda, M.3
Maruyama, H.4
Udaka, F.5
Kameyama, M.6
-
151
-
-
0034057863
-
Protein kinase C binding partners
-
Jaken S., Parker P.J. Protein kinase C binding partners. Bioessays. 22:2000;245-254.
-
(2000)
Bioessays
, vol.22
, pp. 245-254
-
-
Jaken, S.1
Parker, P.J.2
-
152
-
-
0026348872
-
Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway
-
Jellinger K.A. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Molecular and Chemical Neuropathology. 14:1991;153-197.
-
(1991)
Molecular and Chemical Neuropathology
, vol.14
, pp. 153-197
-
-
Jellinger, K.A.1
-
153
-
-
0036048876
-
Recent developments in the pathology of Parkinson's disease
-
Jellinger K.A. Recent developments in the pathology of Parkinson's disease. Journal of Neural Transmission. 62:2003;347-376.
-
(2003)
Journal of Neural Transmission
, vol.62
, pp. 347-376
-
-
Jellinger, K.A.1
-
154
-
-
0032492689
-
Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins
-
Jenco J.M., Rawlingson A., Daniels B., Morris A.J. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry. 37:1998;4901-4909.
-
(1998)
Biochemistry
, vol.37
, pp. 4901-4909
-
-
Jenco, J.M.1
Rawlingson, A.2
Daniels, B.3
Morris, A.J.4
-
155
-
-
0030932673
-
Binding of Abeta to alpha- and beta-synucleins: Identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC
-
Jensen P.H., Hojrup P., Hager H., Nielsen M.S., Jacobsen L., Olesen O.F., et al. Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. Biochemical Journal. 323:1997;539-546.
-
(1997)
Biochemical Journal
, vol.323
, pp. 539-546
-
-
Jensen, P.H.1
Hojrup, P.2
Hager, H.3
Nielsen, M.S.4
Jacobsen, L.5
Olesen, O.F.6
-
156
-
-
0032500599
-
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
-
Jensen P.H., Nielsen M.S., Jakes R., Dotti C.G., Goedert M. Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. Journal of Biological Chemistry. 273:1998;26292-26294.
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 26292-26294
-
-
Jensen, P.H.1
Nielsen, M.S.2
Jakes, R.3
Dotti, C.G.4
Goedert, M.5
-
157
-
-
0033520474
-
Alpha-Synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
-
Jensen P.H., Hager H., Nielsen M.S., Hojrup P., Gliemann J., Jakes R. alpha-Synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. Journal of Biological Chemistry. 274:1999;25481-25489.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 25481-25489
-
-
Jensen, P.H.1
Hager, H.2
Nielsen, M.S.3
Hojrup, P.4
Gliemann, J.5
Jakes, R.6
-
158
-
-
0034647557
-
Microtubule-associated protein 1B Is a component of cortical Lewy bodies and binds alpha-synuclein filaments
-
Jensen P.H., Islam K., Kenney J., Nielsen M.S., Power J., Gai W.P. Microtubule-associated protein 1B Is a component of cortical Lewy bodies and binds alpha-synuclein filaments. Journal of Biological Chemistry. 275:2000;21500-21507.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 21500-21507
-
-
Jensen, P.H.1
Islam, K.2
Kenney, J.3
Nielsen, M.S.4
Power, J.5
Gai, W.P.6
-
159
-
-
0034982249
-
Alpha-Synuclein. Axonal transport, ligand interaction and neurodegeneration
-
Jensen P.H., Gai W.P. alpha-Synuclein. Axonal transport, ligand interaction and neurodegeneration. Advances in Experimental Medicine and Biology. 487:2001;129-134.
-
(2001)
Advances in Experimental Medicine and Biology
, vol.487
, pp. 129-134
-
-
Jensen, P.H.1
Gai, W.P.2
-
160
-
-
0034602296
-
Alpha-Synuclein membrane interactions and lipid specificity
-
Jo E., McLaurin J., Yip C.M., St George-Hyslop P., Fraser P.E. alpha-Synuclein membrane interactions and lipid specificity. Journal of Biological Chemistry. 275:2000;34328-34334.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.2
Yip, C.M.3
St George-Hyslop, P.4
Fraser, P.E.5
-
161
-
-
0036307753
-
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein
-
Jo E., Fuller N., Rand R.P., St George-Hyslop P., Fraser P.E. Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. Journal of Molecular Biology. 315:2002;799-807.
-
(2002)
Journal of Molecular Biology
, vol.315
, pp. 799-807
-
-
Jo, E.1
Fuller, N.2
Rand, R.P.3
St George-Hyslop, P.4
Fraser, P.E.5
-
162
-
-
0037040491
-
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine
-
Junn E., Mouradian M.M. Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neuroscience Letters. 320:2002;146-150.
-
(2002)
Neuroscience Letters
, vol.320
, pp. 146-150
-
-
Junn, E.1
Mouradian, M.M.2
-
164
-
-
0037452813
-
Tissue transglutaminase-induced aggregation of α-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies
-
Junn E., Ronchetti R.D., Quezado M.M., Kim S.-Y., Mouradian M.M. Tissue transglutaminase-induced aggregation of α-synuclein: implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. Proceedings of the National Academy of Sciences of the United States of America. 100:2003;2047-2052.
-
(2003)
Proceedings of the National Academy of Sciences of the United States
, vol.100
, pp. 2047-2052
-
-
Junn, E.1
Ronchetti, R.D.2
Quezado, M.M.3
Kim, S.-Y.4
Mouradian, M.M.5
-
165
-
-
4243721726
-
Physiology and pathophysiology of -synuclein: Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
-
Kahle P.J., Neumann M., Ozmen L. Physiology and pathophysiology of -synuclein: cell culture and transgenic animal models based on a Parkinson's disease-associated protein. Molecular Genetics of Dementia, Proceedings of the Ninth Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, Cambridge, MA, USA. 2000a.
-
(2000)
Molecular Genetics of Dementia, Proceedings of the Ninth Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, Cambridge, MA, USA
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
-
166
-
-
0034280435
-
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain
-
Kahle P.J., Neumann M., Ozmen L., Muller V., Jacobsen H., Schindzielorz A., et al. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain. Journal of Neuroscience. 20:2000b;6365-6373.
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 6365-6373
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Jacobsen, H.5
Schindzielorz, A.6
-
167
-
-
0035191413
-
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
-
Kahle P.J., Neumann M., Ozman L., Muller V., Odoy S., Okamoto N., Jacobsen H., Iwatsubo T., Trojanowski J.Q., Takahashi H., Wakabayashi K., Bogdanovic N., Riederer P., Kretzschmar H.A., Haas C. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. American Journal Pathology. 159:2001;2215-2225.
-
(2001)
American Journal Pathology
, vol.159
, pp. 2215-2225
-
-
Kahle, P.J.1
Neumann, M.2
Ozman, L.3
Muller, V.4
Odoy, S.5
Okamoto, N.6
Jacobsen, H.7
Iwatsubo, T.8
Trojanowski, J.Q.9
Takahashi, H.10
Wakabayashi, K.11
Bogdanovic, N.12
Riederer, P.13
Kretzschmar, H.A.14
Haas, C.15
-
168
-
-
0036304315
-
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
-
Kahle P.J., Neumann M., Ozmen L., Muller V., Jacobsen H., Spooren W., et al. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Reports. 3:2002a;583-588.
-
(2002)
EMBO Reports
, vol.3
, pp. 583-588
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Jacobsen, H.5
Spooren, W.6
-
169
-
-
0036326067
-
Structure/function of alpha-synuclein in health and disease: Rational development of animal models for Parkinson's and related diseases
-
Kahle P.J., Haas C., Kretschmar H.A., Neumann M. Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases. Journal of Neurochemistry. 82:2002b;449-457.
-
(2002)
Journal of Neurochemistry
, vol.82
, pp. 449-457
-
-
Kahle, P.J.1
Haas, C.2
Kretschmar, H.A.3
Neumann, M.4
-
170
-
-
0035815285
-
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole
-
Kakimura J., Kitamura Y., Takata K., Kohno Y., Nomura Y., Taniguchi T. Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. European Journal of Pharmacology. 417:2001;59-67.
-
(2001)
European Journal of Pharmacology
, vol.417
, pp. 59-67
-
-
Kakimura, J.1
Kitamura, Y.2
Takata, K.3
Kohno, Y.4
Nomura, Y.5
Taniguchi, T.6
-
171
-
-
0034739245
-
Incorporation of nitrotyrosine into alpha-tubulin by recombinant mammalian tubulin-tyrosine ligase
-
Kalisz H.M., Erck C., Plessmann U., Wehland J. Incorporation of nitrotyrosine into alpha-tubulin by recombinant mammalian tubulin-tyrosine ligase. Biochimica et Biophysica Acta. 1481:2000;131-138.
-
(2000)
Biochimica et Biophysica Acta
, vol.1481
, pp. 131-138
-
-
Kalisz, H.M.1
Erck, C.2
Plessmann, U.3
Wehland, J.4
-
172
-
-
0034008852
-
Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
-
(In process citation)
-
Kanda S., Bishop J.F., Eglitis M.A., Yang Y., Mouradian M.M. Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation. Neuroscience. 97:2000;279-284. (In process citation).
-
(2000)
Neuroscience
, vol.97
, pp. 279-284
-
-
Kanda, S.1
Bishop, J.F.2
Eglitis, M.A.3
Yang, Y.4
Mouradian, M.M.5
-
173
-
-
0034996655
-
Interaction of alpha-synuclein and synphilin-1: Effect of Parkinson's disease-associated mutations
-
Kawamata H., McLean P.J., Sharma N., Hyman B.T. Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. Journal of Neurochemistry. 77:2001;929-934.
-
(2001)
Journal of Neurochemistry
, vol.77
, pp. 929-934
-
-
Kawamata, H.1
McLean, P.J.2
Sharma, N.3
Hyman, B.T.4
-
174
-
-
0036196220
-
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains
-
Kawamoto Y., Akiguchi I., Nakamura S., Honjyo Y., Shibasaki H., Budka H. 14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains. Journal of Neuropathology and Experimental Neurology. 61:2002a;245-253.
-
(2002)
Journal of Neuropathology and Experimental Neurology
, vol.61
, pp. 245-253
-
-
Kawamoto, Y.1
Akiguchi, I.2
Nakamura, S.3
Honjyo, Y.4
Shibasaki, H.5
Budka, H.6
-
175
-
-
0036896686
-
Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy
-
Kawamoto Y., Akiguchi I., Nakamura S., Budka H. Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy. Annals of Neurology. 52:2002b;722-731.
-
(2002)
Annals of Neurology
, vol.52
, pp. 722-731
-
-
Kawamoto, Y.1
Akiguchi, I.2
Nakamura, S.3
Budka, H.4
-
176
-
-
0037019332
-
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
-
Kim J.H., Auerbach J.M., Rodriguez-Gomez J.A., Velasco I., Gavin D., Lumelsky N., et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature. 418:2002a;50-56.
-
(2002)
Nature
, vol.418
, pp. 50-56
-
-
Kim, J.H.1
Auerbach, J.M.2
Rodriguez-Gomez, J.A.3
Velasco, I.4
Gavin, D.5
Lumelsky, N.6
-
177
-
-
0034492520
-
Structural changes in alpha-synuclein affect its chaperone-like activity in vitro
-
Kim T.D., Paik S.R., Yang C.H., Kim J. Structural changes in alpha-synuclein affect its chaperone-like activity in vitro. Protein Science. 9:2000;2489-2496.
-
(2000)
Protein Science
, vol.9
, pp. 2489-2496
-
-
Kim, T.D.1
Paik, S.R.2
Yang, C.H.3
Kim, J.4
-
178
-
-
0035838284
-
Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin
-
Kim Y.S., Lee D., Lee E.K., Sung J.Y., Chung K.C., Kim J., et al. Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin. Brain Research. 908:2001;93-98.
-
(2001)
Brain Research
, vol.908
, pp. 93-98
-
-
Kim, Y.S.1
Lee, D.2
Lee, E.K.3
Sung, J.Y.4
Chung, K.C.5
Kim, J.6
-
179
-
-
0037137224
-
Structural and functional implications of C-terminal regions of alpha-synuclein
-
Kim T.D., Paik S.R., Yang C.H. Structural and functional implications of C-terminal regions of alpha-synuclein. Biochemistry. 41:2002b;13782-13790.
-
(2002)
Biochemistry
, vol.41
, pp. 13782-13790
-
-
Kim, T.D.1
Paik, S.R.2
Yang, C.H.3
-
180
-
-
0036550101
-
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
-
Kirik D., Rosenblad C., Burger C., Lundberg C., Johansen T.E., Muzyczka N., et al. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. Journal of Neuroscience. 22:2002;2780-2791.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 2780-2791
-
-
Kirik, D.1
Rosenblad, C.2
Burger, C.3
Lundberg, C.4
Johansen, T.E.5
Muzyczka, N.6
-
181
-
-
0345269757
-
Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease
-
Kirik D., Annett L.E., Burger C., Muzyczka N., Mandel R.J., Björklund A. Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: a new primate model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100:2003;2884-2889.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 2884-2889
-
-
Kirik, D.1
Annett, L.E.2
Burger, C.3
Muzyczka, N.4
Mandel, R.J.5
Björklund, A.6
-
182
-
-
0036202813
-
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra
-
Klein R.L., King M.A., Hamby M.E., Meyer E.M. Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Human Gene Therapy. 13:2002;605-612.
-
(2002)
Human Gene Therapy
, vol.13
, pp. 605-612
-
-
Klein, R.L.1
King, M.A.2
Hamby, M.E.3
Meyer, E.M.4
-
183
-
-
0033773403
-
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein
-
Ko L., Mehta N.D., Farrer M., Easson C., Hussey J., Yen S., et al. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein. Journal of Neurochemistry. 75:2000;2546-2554.
-
(2000)
Journal of Neurochemistry
, vol.75
, pp. 2546-2554
-
-
Ko, L.1
Mehta, N.D.2
Farrer, M.3
Easson, C.4
Hussey, J.5
Yen, S.6
-
184
-
-
0037228874
-
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease
-
Kobayashi H., Kruger R., Markopoulou K., Wszolek Z., Chase B., Taka H., et al. Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease. Brain. 126:2003;32-42.
-
(2003)
Brain
, vol.126
, pp. 32-42
-
-
Kobayashi, H.1
Kruger, R.2
Markopoulou, K.3
Wszolek, Z.4
Chase, B.5
Taka, H.6
-
186
-
-
0034676997
-
MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
-
Kowall N.W., Hantraye P., Brouillet E., Beal M.F., McKee A.C., Ferrante R.J. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport. 11:2000;211-213.
-
(2000)
Neuroreport
, vol.11
, pp. 211-213
-
-
Kowall, N.W.1
Hantraye, P.2
Brouillet, E.3
Beal, M.F.4
McKee, A.C.5
Ferrante, R.J.6
-
187
-
-
0346460948
-
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease α-synuclein fibrillogenesis
-
Krishnan S., Chi E.Y., Wood S.J., Kendrick B.S., Li C., Garzon-Rodriguez W., et al. Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease α-synuclein fibrillogenesis. Biochemistry. 42:2003;829-837.
-
(2003)
Biochemistry
, vol.42
, pp. 829-837
-
-
Krishnan, S.1
Chi, E.Y.2
Wood, S.J.3
Kendrick, B.S.4
Li, C.5
Garzon-Rodriguez, W.6
-
188
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease [letter]
-
Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease [letter]. Nature Genetics. 18:1998;106-108.
-
(1998)
Nature Genetics
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
-
189
-
-
0342950666
-
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype
-
Kruger R., Vieira-Saecker A.M., Kuhn W., Berg D., Muller T., Kuhnl N., et al. Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype. Annals of Neurology. 45:1999;611-617.
-
(1999)
Annals of Neurology
, vol.45
, pp. 611-617
-
-
Kruger, R.1
Vieira-Saecker, A.M.2
Kuhn, W.3
Berg, D.4
Muller, T.5
Kuhnl, N.6
-
190
-
-
0036247208
-
Parkinson's disease: One biochemical pathway to fit all genes?
-
Kruger R., Eberhardt O., Riess O., Schulz J.B., Riess O. Parkinson's disease: one biochemical pathway to fit all genes? Trends in Molecular Medicine. 8:2002;236-240.
-
(2002)
Trends in Molecular Medicine
, vol.8
, pp. 236-240
-
-
Kruger, R.1
Eberhardt, O.2
Riess, O.3
Schulz, J.B.4
Riess, O.5
-
191
-
-
0036140094
-
Alzheimer's and Parkinson's disease - Overlapping or synergistic pathologies?
-
Kurosinski P., Guggisberg M., Goetz J. Alzheimer's and Parkinson's disease - overlapping or synergistic pathologies? Trends in Molecular Medicine. 8:2002;3-5.
-
(2002)
Trends in Molecular Medicine
, vol.8
, pp. 3-5
-
-
Kurosinski, P.1
Guggisberg, M.2
Goetz, J.3
-
192
-
-
0035919837
-
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
-
Kuusisto E., Salminen A., Alafuzoff I. Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. Neuroreport. 12:2001;2085-2090.
-
(2001)
Neuroreport
, vol.12
, pp. 2085-2090
-
-
Kuusisto, E.1
Salminen, A.2
Alafuzoff, I.3
-
193
-
-
0036284021
-
Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: Possible role in tangle formation
-
Kuusisto E., Salminen A., Alafuzoff I. Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation. Neuropathology and Applied Neurobiology. 28:2002;228-237.
-
(2002)
Neuropathology and Applied Neurobiology
, vol.28
, pp. 228-237
-
-
Kuusisto, E.1
Salminen, A.2
Alafuzoff, I.3
-
194
-
-
0037129213
-
A proteasomal ATPase subunit recognizes the polyubuquitin degradation signal
-
Lam Y.A., Lawson T.G., Velayutham M., Zweier J.L., Pickart C.M. A proteasomal ATPase subunit recognizes the polyubuquitin degradation signal. Nature. 416:2002;763-767.
-
(2002)
Nature
, vol.416
, pp. 763-767
-
-
Lam, Y.A.1
Lawson, T.G.2
Velayutham, M.3
Zweier, J.L.4
Pickart, C.M.5
-
195
-
-
0036591668
-
Genetics of Parkinson's disease and biochemical studies of implicated gene products
-
Lansbury P.T., Brice A. Genetics of Parkinson's disease and biochemical studies of implicated gene products. Current Opinion in Genetics and Development. 12:(3):2002;299-306.
-
(2002)
Current Opinion in Genetics and Development
, vol.12
, Issue.3
, pp. 299-306
-
-
Lansbury, P.T.1
Brice, A.2
-
196
-
-
0032502276
-
Substrate specificity of deubiquitinating enzymes: Ubiquitin C-terminal hydrolases
-
Larsen C.N., Krantz B.A., Wilkinson K.D. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry. 37:1998;3358-3368.
-
(1998)
Biochemistry
, vol.37
, pp. 3358-3368
-
-
Larsen, C.N.1
Krantz, B.A.2
Wilkinson, K.D.3
-
197
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel H.A., Hartley D., Petre B.M., Walz T., Lansbury P.T.J. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature. 418:2002;291.
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury, P.T.J.5
-
198
-
-
0344505849
-
Tau interacts with src-family non-receptor tyrosine kinases
-
Lee G., Newman S.T., Gard D.L., Band H., Panchamoorthy G. Tau interacts with src-family non-receptor tyrosine kinases. Journal of Cell Science. 111:1998;3167-3177.
-
(1998)
Journal of Cell Science
, vol.111
, pp. 3167-3177
-
-
Lee, G.1
Newman, S.T.2
Gard, D.L.3
Band, H.4
Panchamoorthy, G.5
-
199
-
-
0035109909
-
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult
-
Lee M., Hyun D., Halliwell B., Jenner P. Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult. Journal of Neurochemistry. 76:2001;998-1009.
-
(2001)
Journal of Neurochemistry
, vol.76
, pp. 998-1009
-
-
Lee, M.1
Hyun, D.2
Halliwell, B.3
Jenner, P.4
-
200
-
-
0037073747
-
Characterization of cytoplasmic alpha-synuclein aggregates: Fibril formation is tightly linked to the inclusion forming process in cells
-
Lee H.J., Lee S.J. Characterization of cytoplasmic alpha-synuclein aggregates: fibril formation is tightly linked to the inclusion forming process in cells. Journal of Biological Chemistry. 277:2002;48976-48983.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 48976-48983
-
-
Lee, H.J.1
Lee, S.J.2
-
201
-
-
0037085288
-
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
-
Lee H.J., Shin S.Y., Choi C., Lee Y.H., Lee S.J. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. Journal of Biological Chemistry. 277:2002a;5411-5417.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 5411-5417
-
-
Lee, H.J.1
Shin, S.Y.2
Choi, C.3
Lee, Y.H.4
Lee, S.J.5
-
202
-
-
0036724202
-
Alpha-Synuclein exhibits competitive interaction between calmodulin and synthetic membranes
-
Lee D., Lee S.Y., Lee E.N., Chang C.S., Paik S.R. alpha-Synuclein exhibits competitive interaction between calmodulin and synthetic membranes. Journal of Neurochemistry. 82:2002b;1007-1017.
-
(2002)
Journal of Neurochemistry
, vol.82
, pp. 1007-1017
-
-
Lee, D.1
Lee, S.Y.2
Lee, E.N.3
Chang, C.S.4
Paik, S.R.5
-
203
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 - > Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
-
Lee M.K., Stirling W., Xu Y., Xu X., Qui D., Mandir A.S., et al. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 - > Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 99:2002c;8968-8973.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 8968-8973
-
-
Lee, M.K.1
Stirling, W.2
Xu, Y.3
Xu, X.4
Qui, D.5
Mandir, A.S.6
-
205
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease [letter]
-
Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., et al. The ubiquitin pathway in Parkinson's disease [letter]. Nature. 395:1998;451-452.
-
(1998)
Nature
, vol.395
, pp. 451-452
-
-
Leroy, E.1
Boyer, R.2
Auburger, G.3
Leube, B.4
Ulm, G.5
Mezey, E.6
-
206
-
-
0035949542
-
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
-
Li J., Uversky V.N., Fink A.L. Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry. 40:2001;11604-11613.
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J.1
Uversky, V.N.2
Fink, A.L.3
-
207
-
-
0037067993
-
Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS
-
Li J.Y., Henning J.P., Dahlstrom A. Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Neuroscience. 113:2002;463-478.
-
(2002)
Neuroscience
, vol.113
, pp. 463-478
-
-
Li, J.Y.1
Henning, J.P.2
Dahlstrom, A.3
-
208
-
-
18344417178
-
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in pesenilin and amyloid precursor protein genes
-
Lippa C.F., Fujiwara H., Mann D.M., Giasson B., Baba M., Schmidt M.L., et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in pesenilin and amyloid precursor protein genes. American Journal of Pathology. 153:1998;1365-1370.
-
(1998)
American Journal of Pathology
, vol.153
, pp. 1365-1370
-
-
Lippa, C.F.1
Fujiwara, H.2
Mann, D.M.3
Giasson, B.4
Baba, M.5
Schmidt, M.L.6
-
209
-
-
0032990543
-
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
-
Lippa C.F., Schmidt M.L., Lee V.M., Trojanowski J.Q. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Annals of Neurology. 45:1999;353-357.
-
(1999)
Annals of Neurology
, vol.45
, pp. 353-357
-
-
Lippa, C.F.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
-
210
-
-
0034759869
-
Alpha-Synuclein in familial Alzheimer disease: Epitope mapping parallels dementia with Lewy bodies and Parkinson disease
-
Lippa C.F., Schmidt M.L., Lee V.M., Trojanowski J.Q. alpha-Synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease. Archives of Neurology. 58:2001;1817-1820.
-
(2001)
Archives of Neurology
, vol.58
, pp. 1817-1820
-
-
Lippa, C.F.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
-
211
-
-
0037131567
-
The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
-
Liu Y., Fallon L., Lashuel H.A., Liu Z., Lansbury P.T. The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility. Cell. 111:2002;209-218.
-
(2002)
Cell
, vol.111
, pp. 209-218
-
-
Liu, Y.1
Fallon, L.2
Lashuel, H.A.3
Liu, Z.4
Lansbury, P.T.5
-
212
-
-
0031048598
-
Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation
-
Llinas R., Moreno H., Sugimori M., Mohammadi M., Schlessinger J. Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 94:1997;1990-1994.
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 1990-1994
-
-
Llinas, R.1
Moreno, H.2
Sugimori, M.3
Mohammadi, M.4
Schlessinger, J.5
-
213
-
-
0036679197
-
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
-
Lo Bianco C., Ridet J.-L., Schneider B.L., Deglon N., Aebischer P. α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 99:2002;10813-10818.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 10813-10818
-
-
Lo Bianco, C.1
Ridet, J.-L.2
Schneider, B.L.3
Deglon, N.4
Aebischer, P.5
-
214
-
-
0037064078
-
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
-
Lotharius J., Barg S., Wiekop P., Lundberg C., Raymon H.K., Brundin P. Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. Journal of Biological Chemistry. 277:2002;38884-38894.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 38884-38894
-
-
Lotharius, J.1
Barg, S.2
Wiekop, P.3
Lundberg, C.4
Raymon, H.K.5
Brundin, P.6
-
215
-
-
0036797552
-
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
-
Lotharius J., Brundin P. Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Human Molecular Genetics. 11:2002a;2395-2407.
-
(2002)
Human Molecular Genetics
, vol.11
, pp. 2395-2407
-
-
Lotharius, J.1
Brundin, P.2
-
216
-
-
0036884733
-
Pathogenesis of Parkinson's disease: Dopamine, vesicles and α-synuclein
-
Lotharius J., Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein. Nature Reviews Neuroscience. 3:2002b;1-11.
-
(2002)
Nature Reviews Neuroscience
, vol.3
, pp. 1-11
-
-
Lotharius, J.1
Brundin, P.2
-
217
-
-
0025326719
-
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases
-
Lowe J., McDermott H., Landon M., Mayer R.J., Wilkinson K.D. Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases. Journal of Pathology. 161:1990;153-160.
-
(1990)
Journal of Pathology
, vol.161
, pp. 153-160
-
-
Lowe, J.1
McDermott, H.2
Landon, M.3
Mayer, R.J.4
Wilkinson, K.D.5
-
218
-
-
0032564235
-
Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on genetic susceptibility in Parkinson's disease and the French Parkinson's Disease Genetics Study Group
-
Lucking C.B., Abbas N., Durr A., Bonifati V., Bonnet A.M., de B.T. Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism. The European Consortium on genetic susceptibility in Parkinson's disease and the French Parkinson's Disease Genetics Study Group. Lancet. 352:1998;1355-1356.
-
(1998)
Lancet
, vol.352
, pp. 1355-1356
-
-
Lucking, C.B.1
Abbas, N.2
Durr, A.3
Bonifati, V.4
Bonnet, A.M.5
De, B.T.6
-
219
-
-
0342368772
-
Association between early-onset Parkinson's disease and mutations in the parkin gene. French Parkinson's Disease Genetics Study Group
-
Lucking C.B., Durr A., Bonifati V., Vaughan J., De M.G., Gasser T., et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. French Parkinson's Disease Genetics Study Group. New England Journal of Medicine. 342:2000;1560-1567.
-
(2000)
New England Journal of Medicine
, vol.342
, pp. 1560-1567
-
-
Lucking, C.B.1
Durr, A.2
Bonifati, V.3
Vaughan, J.4
De, M.G.5
Gasser, T.6
-
220
-
-
0042477558
-
Alpha-Synuclein and presynaptic function: Implications for Parkinson's disease
-
Lykkebo S., Jensen P.H. Alpha-Synuclein and presynaptic function: implications for Parkinson's disease. Neuromolecular Medicine. 2:2002;115-129.
-
(2002)
Neuromolecular Medicine
, vol.2
, pp. 115-129
-
-
Lykkebo, S.1
Jensen, P.H.2
-
221
-
-
0037127197
-
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: Paraquat and alpha-synuclein
-
Manning-Bog A.B., McCormack A.L., Li J., Uversky V.N., Fink A.L., Di M.D. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. Journal of Biological Chemistry. 277:2002;1641-1644.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 1641-1644
-
-
Manning-Bog, A.B.1
McCormack, A.L.2
Li, J.3
Uversky, V.N.4
Fink, A.L.5
Di, M.D.6
-
222
-
-
0035861048
-
Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
-
Martin E.R., Scott W.K., Nance M.A., Watts R.L., Hubble J.P., Koller W.C., et al. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. Journal of American Medical Association. 286:2002;2245-2250.
-
(2002)
Journal of American Medical Association
, vol.286
, pp. 2245-2250
-
-
Martin, E.R.1
Scott, W.K.2
Nance, M.A.3
Watts, R.L.4
Hubble, J.P.5
Koller, W.C.6
-
223
-
-
85031173344
-
Parkinson's disease associated α-synuclein is a calmodulin substrate
-
in press
-
Martinez, J., Moeller, I., Erdjument-Bromage, H., Tempst, P., Lauring, B. Parkinson's disease associated α-synuclein is a calmodulin substrate. Journal of Biological Chemistry, in press.
-
Journal of Biological Chemistry
-
-
Martinez, J.1
Moeller, I.2
Erdjument-Bromage, H.3
Tempst, P.4
Lauring, B.5
-
224
-
-
0034653871
-
Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease
-
Marui W., Iseki E., Ueda K., Kosaka K. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. Journal of Neurological Sciences. 174:2000;81-84.
-
(2000)
Journal of Neurological Sciences
, vol.174
, pp. 81-84
-
-
Marui, W.1
Iseki, E.2
Ueda, K.3
Kosaka, K.4
-
225
-
-
0037196894
-
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies
-
Marui W., Iseki E., Nakai T., Miura S., Kato M., Ueda K., et al. Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. Journal of Neurological Sciences. 195:2002;153-159.
-
(2002)
Journal of Neurological Sciences
, vol.195
, pp. 153-159
-
-
Marui, W.1
Iseki, E.2
Nakai, T.3
Miura, S.4
Kato, M.5
Ueda, K.6
-
226
-
-
0034681471
-
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
-
Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 287:2000;1265-1269.
-
(2000)
Science
, vol.287
, pp. 1265-1269
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Mallory, M.4
Hashimoto, M.5
Takeda, A.6
-
227
-
-
0035834076
-
Beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
-
Masliah E., Rockenstein E., Veinbergs I., Sagara Y., Mallory M., Hashimoto M., et al. beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;12245-12250.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 12245-12250
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Sagara, Y.4
Mallory, M.5
Hashimoto, M.6
-
228
-
-
0034979314
-
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
-
Matsuoka Y., Vila M., Lincoln S., McCormack A., Picciano M., LaFrancois J., et al. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8:2002;535-539.
-
(2002)
Neurobiology of Disease
, vol.8
, pp. 535-539
-
-
Matsuoka, Y.1
Vila, M.2
Lincoln, S.3
McCormack, A.4
Picciano, M.5
LaFrancois, J.6
-
229
-
-
0034676757
-
Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study
-
McKeith I., Del S.T., Spano P., Emre M., Wesnes K., Anand R., et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet. 356:2000;2031-2036.
-
(2000)
Lancet
, vol.356
, pp. 2031-2036
-
-
McKeith, I.1
Del, S.T.2
Spano, P.3
Emre, M.4
Wesnes, K.5
Anand, R.6
-
231
-
-
0033724436
-
Subcellular localization of alpha-synuclein in primary neuronal cultures: Effect of missense mutations
-
McLean P.J., Ribich S., Hyman B.T. Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations. Journal of Neural Transmission-Supplement (58). 2000;53-63.
-
(2000)
Journal of Neural Transmission-Supplement (58)
, pp. 53-63
-
-
McLean, P.J.1
Ribich, S.2
Hyman, B.T.3
-
232
-
-
0035859226
-
Alpha-Synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
-
McLean P.J., Kawamata H., Hyman B.T. alpha-Synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience. 104:2001;901-912.
-
(2001)
Neuroscience
, vol.104
, pp. 901-912
-
-
McLean, P.J.1
Kawamata, H.2
Hyman, B.T.3
-
233
-
-
0037012778
-
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: Role of the carboxy-terminus in alpha-synuclein aggregation
-
McLean P.J., Hyman B.T. An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation. Neuroscience Letters. 323:2002;219-223.
-
(2002)
Neuroscience Letters
, vol.323
, pp. 219-223
-
-
McLean, P.J.1
Hyman, B.T.2
-
234
-
-
0036846119
-
TorsinA and heat shock proteins act as molecular chaperones: Suppression of α-synuclein aggregation
-
McLean P.J., Kawamata H., Shariff S., Hewett J., Sharma N., Ueda K., et al. TorsinA and heat shock proteins act as molecular chaperones: suppression of α-synuclein aggregation. Journal of Neurochemistry. 83:2002;846-854.
-
(2002)
Journal of Neurochemistry
, vol.83
, pp. 846-854
-
-
McLean, P.J.1
Kawamata, H.2
Shariff, S.3
Hewett, J.4
Sharma, N.5
Ueda, K.6
-
235
-
-
0035910634
-
Proteasomal function is impaired in substantia nigra in Parkinson's disease
-
McNaught K.S., Jenner P. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neuroscience Letters. 297:2001;191-194.
-
(2001)
Neuroscience Letters
, vol.297
, pp. 191-194
-
-
McNaught, K.S.1
Jenner, P.2
-
236
-
-
0037378898
-
Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease
-
McNaught, K.St.P., Olanow, C.W., 2003. Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease. Annals Neurology 53 (Supplement 3), S73-S86.
-
(2003)
Annals Neurology
, vol.53
, Issue.SUPPL. 3
-
-
McNaught, K.St.P.1
Olanow, C.W.2
-
237
-
-
0035430788
-
Failure of the ubiquitin-proteasome system in Parkinson's disease
-
McNaught K.S., Olanow C.W., Halliwell B., Isacson O., Jenner P. Failure of the ubiquitin-proteasome system in Parkinson's disease. Nature Reviews Neuroscience. 2:2001;589-594.
-
(2001)
Nature Reviews Neuroscience
, vol.2
, pp. 589-594
-
-
McNaught, K.S.1
Olanow, C.W.2
Halliwell, B.3
Isacson, O.4
Jenner, P.5
-
238
-
-
0036316947
-
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
-
McNaught K.S., Mytilineou C., Jnobaptiste R., Yabut J., Shashidharan P., Jennert P., et al. Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures. Journal of Neurochemistry. 81:2002a;301-306.
-
(2002)
Journal of Neurochemistry
, vol.81
, pp. 301-306
-
-
McNaught, K.S.1
Mytilineou, C.2
Jnobaptiste, R.3
Yabut, J.4
Shashidharan, P.5
Jennert, P.6
-
239
-
-
0037036904
-
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
-
McNaught K.S., Bjorklund L.M., Belizaire R., Isacson O., Jenner P., Olanow C.W. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport. 13:2002b;1437-1441.
-
(2002)
Neuroreport
, vol.13
, pp. 1437-1441
-
-
McNaught, K.S.1
Bjorklund, L.M.2
Belizaire, R.3
Isacson, O.4
Jenner, P.5
Olanow, C.W.6
-
240
-
-
0037227397
-
Altered proteasomal function in sporadic Parkinson's disease
-
McNaught K.S., Belizaire R., Isacson O., Jenner P., Olanow C.W. Altered proteasomal function in sporadic Parkinson's disease. Experimental Neurology. 179:2003;38-46.
-
(2003)
Experimental Neurology
, vol.179
, pp. 38-46
-
-
McNaught, K.S.1
Belizaire, R.2
Isacson, O.3
Jenner, P.4
Olanow, C.W.5
-
241
-
-
0037159608
-
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
-
Meredith G.E., Totterdell S., Petroske E., Santa Cruz K., Callison R.C., Lau Y.-S. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Research. 956:2002;156-165.
-
(2002)
Brain Research
, vol.956
, pp. 156-165
-
-
Meredith, G.E.1
Totterdell, S.2
Petroske, E.3
Santa Cruz, K.4
Callison, R.C.5
Lau, Y.-S.6
-
242
-
-
0031794794
-
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease
-
(Published erratum appears in Molecular Psychiatry 1999 Mar;4(2), 197)
-
Mezey E., Dehejia A.M., Harta G., Tresser N., Suchy S.F., Nussbaum R.L., et al. Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease. Molecular Psychiatry. 3:1998;493-499. (Published erratum appears in Molecular Psychiatry 1999 Mar;4(2), 197).
-
(1998)
Molecular Psychiatry
, vol.3
, pp. 493-499
-
-
Mezey, E.1
Dehejia, A.M.2
Harta, G.3
Tresser, N.4
Suchy, S.F.5
Nussbaum, R.L.6
-
243
-
-
0033843335
-
Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage
-
Mihm M.J., Jing L., Bauer J.A. Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage. Journal of Cardiovascular Pharmacology. 36:2000;182-187.
-
(2000)
Journal of Cardiovascular Pharmacology
, vol.36
, pp. 182-187
-
-
Mihm, M.J.1
Jing, L.2
Bauer, J.A.3
-
244
-
-
0035380774
-
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo
-
Mihm M.J., Schanbacher B.L., Wallace B.L., Wallace L.J., Uretsky N.J., Bauer J.A. Free 3-nitrotyrosine causes striatal neurodegeneration in vivo. Journal of Neuroscience. 21:(11):2001;RC149.
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.11
, pp. 149
-
-
Mihm, M.J.1
Schanbacher, B.L.2
Wallace, B.L.3
Wallace, L.J.4
Uretsky, N.J.5
Bauer, J.A.6
-
245
-
-
17044447638
-
Familial Parkinson's disease. alpha-Synuclein and parkin
-
Mizuno Y., Hattori N., Kitada T., Matsumine H., Mori H., Shimura H., et al. Familial Parkinson's disease. alpha-Synuclein and parkin. Advances in Neurology. 86:2001;13-21.
-
(2001)
Advances in Neurology
, vol.86
, pp. 13-21
-
-
Mizuno, Y.1
Hattori, N.2
Kitada, T.3
Matsumine, H.4
Mori, H.5
Shimura, H.6
-
246
-
-
0036723972
-
Meta-analysis of α-synuclein/NACP polymorphism in Parkinson's disease in Japan
-
Mizuta I., Nishimura M., Mizuta E., Yamasaki S., Ohta M., Kuno S. Meta-analysis of α-synuclein/NACP polymorphism in Parkinson's disease in Japan. Journal of Neurology Neurosurgery and Psychiatry. 73:2002;350.
-
(2002)
Journal of Neurology Neurosurgery and Psychiatry
, vol.73
, pp. 350
-
-
Mizuta, I.1
Nishimura, M.2
Mizuta, E.3
Yamasaki, S.4
Ohta, M.5
Kuno, S.6
-
247
-
-
0035742561
-
Expression of alpha-synuclein in non-apoptotic, slowly degenerating facial motoneurones
-
Moran L.B., Kosel S., Spitzer C., Schwaiger F.W., Riess O., Kreutzberg G.W., et al. Expression of alpha-synuclein in non-apoptotic, slowly degenerating facial motoneurones. Journal of Neurocytology. 30:2001;515-521.
-
(2001)
Journal of Neurocytology
, vol.30
, pp. 515-521
-
-
Moran, L.B.1
Kosel, S.2
Spitzer, C.3
Schwaiger, F.W.4
Riess, O.5
Kreutzberg, G.W.6
-
248
-
-
0036315240
-
Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment
-
Mori F., Tanji K., Yoshimoto M., Takahashi H., Wakabayashi K. Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment. Experimental Neurology. 176:2002;98-104.
-
(2002)
Experimental Neurology
, vol.176
, pp. 98-104
-
-
Mori, F.1
Tanji, K.2
Yoshimoto, M.3
Takahashi, H.4
Wakabayashi, K.5
-
249
-
-
0031721141
-
Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q
-
Mori H., Kondo T., Yokochi M., Matsumine H., Nakagawa-Hattori Y., Miyake T., et al. Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q. Neurology. 51:1998;890-892.
-
(1998)
Neurology
, vol.51
, pp. 890-892
-
-
Mori, H.1
Kondo, T.2
Yokochi, M.3
Matsumine, H.4
Nakagawa-Hattori, Y.5
Miyake, T.6
-
250
-
-
0037154184
-
Recent advances in the genetics and pathogenesis of Parkinson disease
-
Mouradian M.M. Recent advances in the genetics and pathogenesis of Parkinson disease. Neurology. 58:2002;179-185.
-
(2002)
Neurology
, vol.58
, pp. 179-185
-
-
Mouradian, M.M.1
-
251
-
-
0037014426
-
Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones?
-
Muchowski P.J. Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones? Neuron. 35:2002;9-12.
-
(2002)
Neuron
, vol.35
, pp. 9-12
-
-
Muchowski, P.J.1
-
252
-
-
0034193399
-
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
-
Murphy D.D., Rueter S.M., Trojanowski J.Q., Lee V.M. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. Journal of Neuroscience. 20:2000;3214-3220.
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 3214-3220
-
-
Murphy, D.D.1
Rueter, S.M.2
Trojanowski, J.Q.3
Lee, V.M.4
-
253
-
-
0031950974
-
Distribution of mRNA encoding Tat-binding protein-1 (TBP-1), a component of 26S proteasome, in the rat brain
-
Nakamura T., Tanaka T., Nagano T., Yoneda T., Takagi H., Sato M. Distribution of mRNA encoding Tat-binding protein-1 (TBP-1), a component of 26S proteasome, in the rat brain. Brain Research Molecular Brain Research. 53:1998;321-327.
-
(1998)
Brain Research Molecular Brain Research
, vol.53
, pp. 321-327
-
-
Nakamura, T.1
Tanaka, T.2
Nagano, T.3
Yoneda, T.4
Takagi, H.5
Sato, M.6
-
254
-
-
0037134776
-
Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases
-
Nakamura T., Yamashita H., Nagano Y., Takahashi T., Avraham S., Avraham H., et al. Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases. FEBS Letters. 521:2002;190-194.
-
(2002)
FEBS Letters
, vol.521
, pp. 190-194
-
-
Nakamura, T.1
Yamashita, H.2
Nagano, Y.3
Takahashi, T.4
Avraham, S.5
Avraham, H.6
-
255
-
-
0033515471
-
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation
-
(Published erratum appears in Journal of Biological Chemistry 1999 May 7;274(19):13728)
-
Narhi L., Wood S.J., Steavenson S., Jiang Y., Wu G.M., Anafi D., et al. Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. Journal of Biological Chemistry. 274:1999;9843-9846. (Published erratum appears in Journal of Biological Chemistry 1999 May 7;274(19):13728).
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
Jiang, Y.4
Wu, G.M.5
Anafi, D.6
-
257
-
-
0029802997
-
The greater limbic system, the emotional motor system and the brain
-
Nieuwenhuys R. The greater limbic system, the emotional motor system and the brain. Progress in Brain Research. 107:1996;551-580.
-
(1996)
Progress in Brain Research
, vol.107
, pp. 551-580
-
-
Nieuwenhuys, R.1
-
258
-
-
0036855635
-
Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
-
Neumann M., Kahle P.J., Giasson B.I., Ozmen L., Borroni E., Spooren W., et al. Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. Journal of Clinical Investigation. 110:2002;1429-1439.
-
(2002)
Journal of Clinical Investigation
, vol.110
, pp. 1429-1439
-
-
Neumann, M.1
Kahle, P.J.2
Giasson, B.I.3
Ozmen, L.4
Borroni, E.5
Spooren, W.6
-
259
-
-
0025995324
-
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
-
O'Dell T.J., Kandel E.R., Grant S.G. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature. 353:1991;558-560.
-
(1991)
Nature
, vol.353
, pp. 558-560
-
-
O'Dell, T.J.1
Kandel, E.R.2
Grant, S.G.3
-
260
-
-
0037112329
-
Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals
-
O'Kelly I., Butler M.H., Zilberberg N., Goldstein S.A.N. Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell. 111:2002;577-588.
-
(2002)
Cell
, vol.111
, pp. 577-588
-
-
O'Kelly, I.1
Butler, M.H.2
Zilberberg, N.3
Goldstein, S.A.N.4
-
261
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi M., Walter J., Koyama A., Nakajo S., Baba M., Iwatsubo T., et al. Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. Journal of Biological Chemistry. 275:2000;390-397.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
-
262
-
-
0034327510
-
Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex
-
Orlowski M., Wilk S. Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex. Archives of Biochemistry and Biophysics. 383:2000;1-16.
-
(2000)
Archives of Biochemistry and Biophysics
, vol.383
, pp. 1-16
-
-
Orlowski, M.1
Wilk, S.2
-
263
-
-
0034663039
-
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity
-
(In process citation)
-
Ostrerova-Golts N., Petrucelli L., Hardy J., Lee J.M., Farer M., Wolozin B. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. Journal of Neuroscience. 20:2000;6048-6054. (In process citation).
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 6048-6054
-
-
Ostrerova-Golts, N.1
Petrucelli, L.2
Hardy, J.3
Lee, J.M.4
Farer, M.5
Wolozin, B.6
-
264
-
-
0033565874
-
Alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
-
Ostrerova N., Petrucelli L., Farrer M., Mehta N., Choi P., Hardy J. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. Journal of Neuroscience. 19:1999;5782-5791.
-
(1999)
Journal of Neuroscience
, vol.19
, pp. 5782-5791
-
-
Ostrerova, N.1
Petrucelli, L.2
Farrer, M.3
Mehta, N.4
Choi, P.5
Hardy, J.6
-
265
-
-
16944366666
-
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
-
Ozelius L.J., Hewett J.W., Page C.E., Bressman S.B., Kramer P.L., Shalish C., et al. The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nature Genetics. 1:1997;40-48.
-
(1997)
Nature Genetics
, vol.1
, pp. 40-48
-
-
Ozelius, L.J.1
Hewett, J.W.2
Page, C.E.3
Bressman, S.B.4
Kramer, P.L.5
Shalish, C.6
-
266
-
-
0031571624
-
Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid
-
Paik S.R., Lee J.H., Kim D.H., Chang C.S., Kim J. Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid. Archives of Biochemistry and Biophysics. 344:1997;325-334.
-
(1997)
Archives of Biochemistry and Biophysics
, vol.344
, pp. 325-334
-
-
Paik, S.R.1
Lee, J.H.2
Kim, D.H.3
Chang, C.S.4
Kim, J.5
-
267
-
-
0033564726
-
Copper(II)-induced self-oligomerization of alpha-synuclein
-
Paik S.R., Shin H.J., Lee J.H., Chang C.S., Kim J. Copper(II)-induced self-oligomerization of alpha-synuclein. Biochemical Journal. 340:1999;821-828.
-
(1999)
Biochemical Journal
, vol.340
, pp. 821-828
-
-
Paik, S.R.1
Shin, H.J.2
Lee, J.H.3
Chang, C.S.4
Kim, J.5
-
268
-
-
0034660568
-
Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide
-
Paik S.R., Shin H.J., Lee J.H. Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide. Archives of Biochemistry and Biophysics. 378:2000;269-277.
-
(2000)
Archives of Biochemistry and Biophysics
, vol.378
, pp. 269-277
-
-
Paik, S.R.1
Shin, H.J.2
Lee, J.H.3
-
269
-
-
0037144401
-
Gamma-Synuclein promotes cancer cell survival and inhibits stress- and chemotherapeutic drug-induced apoptosis by modulating MAPK pathways
-
Pan Z.Z., Bruening W., Giasson B.I., Lee V.M., Godwin A.K. gamma-Synuclein promotes cancer cell survival and inhibits stress- and chemotherapeutic drug-induced apoptosis by modulating MAPK pathways. Journal of Biological Chemistry. 277:2002;35050-35060.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 35050-35060
-
-
Pan, Z.Z.1
Bruening, W.2
Giasson, B.I.3
Lee, V.M.4
Godwin, A.K.5
-
270
-
-
0011761615
-
Protein tyrosine phosphorylation in synaptic vesicles
-
Pang D.T., Wang J.K., Valtorta F., Benfenati F., Greengard P. Protein tyrosine phosphorylation in synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America. 85:1988;762-766.
-
(1988)
Proceedings of the National Academy of Sciences of the United States of America
, vol.85
, pp. 762-766
-
-
Pang, D.T.1
Wang, J.K.2
Valtorta, F.3
Benfenati, F.4
Greengard, P.5
-
271
-
-
18644371727
-
Mice expressing the α1B-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation
-
Papay R., Zuscik M.J., Ross S.A., Yun J., McCune D.F., Gonzalez-Cagrera P., et al. Mice expressing the α1B-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation. Journal of Neurochemistry. 83:2002;623-634.
-
(2002)
Journal of Neurochemistry
, vol.83
, pp. 623-634
-
-
Papay, R.1
Zuscik, M.J.2
Ross, S.A.3
Yun, J.4
McCune, D.F.5
Gonzalez-Cagrera, P.6
-
272
-
-
0037426346
-
Beta-synuclein inhibits the formation of alpha-synuclein protofibrils: A possible therapeutic strategy against Parkinson's disease
-
Park J.Y., Lansbury P.T. Beta-synuclein inhibits the formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry. 42:2003;3696-3700.
-
(2003)
Biochemistry
, vol.42
, pp. 3696-3700
-
-
Park, J.Y.1
Lansbury, P.T.2
-
273
-
-
0033065326
-
Induction of the Tat-binding protein 1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases
-
Park B.W., O'Rourke D.M., Wang Q., Davis J.G., Post A., Qian X., et al. Induction of the Tat-binding protein 1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 96:1999;6434-6438.
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, pp. 6434-6438
-
-
Park, B.W.1
O'Rourke, D.M.2
Wang, Q.3
Davis, J.G.4
Post, A.5
Qian, X.6
-
274
-
-
0037177241
-
Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: Role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability
-
Park S.M., Jung H.Y., Chung K.C., Rhim H., Park J.H., Kim J. Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability. Biochemistry. 41:2002a;4137-4146.
-
(2002)
Biochemistry
, vol.41
, pp. 4137-4146
-
-
Park, S.M.1
Jung, H.Y.2
Chung, K.C.3
Rhim, H.4
Park, J.H.5
Kim, J.6
-
275
-
-
0036616838
-
Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: Potential mechanism of neurotoxicity in dopamine neurons
-
Park S.U., Ferrer J.V., Javitch J.A., Kuhn D.M. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. Journal of Neuroscience. 22:2002b;4399-4405.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 4399-4405
-
-
Park, S.U.1
Ferrer, J.V.2
Javitch, J.A.3
Kuhn, D.M.4
-
276
-
-
0035526251
-
Analysis of the coding and the 5′ flanking regions of the alpha-synuclein gene in patients with Parkinson's disease
-
Pastor P., Munoz E., Ezquerra M., Obach V., Marti M.J., Valldeoriola F., et al. Analysis of the coding and the 5′ flanking regions of the alpha-synuclein gene in patients with Parkinson's disease. Movement Disorder. 16:2001;1115-1119.
-
(2001)
Movement Disorder
, vol.16
, pp. 1115-1119
-
-
Pastor, P.1
Munoz, E.2
Ezquerra, M.3
Obach, V.4
Marti, M.J.5
Valldeoriola, F.6
-
277
-
-
0036589893
-
Further extension of the H1 haplotype associated with progressive supranuclear palsy
-
Pastor P., Ezquerra M., Tolosa E., Munoz E., Jose Marti M., Valldeoriola F., et al. Further extension of the H1 haplotype associated with progressive supranuclear palsy. Movement Disorder. 17:2002;550-556.
-
(2002)
Movement Disorder
, vol.17
, pp. 550-556
-
-
Pastor, P.1
Ezquerra, M.2
Tolosa, E.3
Munoz, E.4
Jose Marti, M.5
Valldeoriola, F.6
-
278
-
-
0035887860
-
Induction of alpha-synuclein aggregation by intracellular nitrative insult
-
Paxinou E., Chen Q., Weisse M., Giasson B.I., Norris E.H., Rueter S.M., et al. Induction of alpha-synuclein aggregation by intracellular nitrative insult. Journal of Neuroscience. 21:2001;8053-8061.
-
(2001)
Journal of Neuroscience
, vol.21
, pp. 8053-8061
-
-
Paxinou, E.1
Chen, Q.2
Weisse, M.3
Giasson, B.I.4
Norris, E.H.5
Rueter, S.M.6
-
281
-
-
0037092442
-
A role for alpha-synuclein in the regulation of dopamine biosynthesis
-
Perez R.G., Waymire J.C., Lin E., Liu J.J., Guo F., Zigmond M.J. A role for alpha-synuclein in the regulation of dopamine biosynthesis. Journal of Neuroscience. 22:2002;3090-3099.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 3090-3099
-
-
Perez, R.G.1
Waymire, J.C.2
Lin, E.3
Liu, J.J.4
Guo, F.5
Zigmond, M.J.6
-
282
-
-
0034602271
-
Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
(In process citation)
-
Perrin R.J., Woods W.S., Clayton D.F., George J.M. Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. Journal of Biological Chemistry. 275:2000;34393-34398. (In process citation).
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
283
-
-
0035834655
-
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
-
Perrin R.J., Woods W.S., Clayton D.F., George J.M. Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. Journal of Biological Chemistry. 276:2001;41958-41962.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 41958-41962
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
284
-
-
0037137702
-
Parkin protects against the toxicity associated with mutant α-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
-
Petrucelli L., O'Farrell C., Lockhart P.J., Baptista M., Kehoe K., Vink L., et al. Parkin protects against the toxicity associated with mutant α-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 36:2002;1007-1019.
-
(2002)
Neuron
, vol.36
, pp. 1007-1019
-
-
Petrucelli, L.1
O'Farrell, C.2
Lockhart, P.J.3
Baptista, M.4
Kehoe, K.5
Vink, L.6
-
285
-
-
0037117499
-
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques
-
Perutz M.F., Pope B.J., Owen D., Wanker E.E., Scherzinger E. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Proceedings of the National Academy of Sciences of the United States of America. 99:2002;5596-5600.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 5596-5600
-
-
Perutz, M.F.1
Pope, B.J.2
Owen, D.3
Wanker, E.E.4
Scherzinger, E.5
-
286
-
-
0033930531
-
Aggregation of (α-synuclein/NACP in the neuronal and glial cells in diffuse Lewy body disease: A survey of six patients
-
Piao Y.S., Wakabayashi K., Hayashi S., Yoshimoto M., Takahashi H. Aggregation of (α-synuclein/NACP in the neuronal and glial cells in diffuse Lewy body disease: a survey of six patients. Clinical Neuropathology. 19:2000;163-169.
-
(2000)
Clinical Neuropathology
, vol.19
, pp. 163-169
-
-
Piao, Y.S.1
Wakabayashi, K.2
Hayashi, S.3
Yoshimoto, M.4
Takahashi, H.5
-
287
-
-
0035108490
-
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration
-
Piao Y.S., Hayashi S., Hasegawa M., Wakabayashi K., Yamada M., Yoshimoto M., et al. Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathologica. 101:2001;285-293.
-
(2001)
Acta Neuropathologica
, vol.101
, pp. 285-293
-
-
Piao, Y.S.1
Hayashi, S.2
Hasegawa, M.3
Wakabayashi, K.4
Yamada, M.5
Yoshimoto, M.6
-
289
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
(See comments)
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047. (See comments).
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
-
290
-
-
0034722098
-
Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons
-
Pong K., Doctrow S.R., Baudry M. Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Research. 881:2000;182-189.
-
(2000)
Brain Research
, vol.881
, pp. 182-189
-
-
Pong, K.1
Doctrow, S.R.2
Baudry, M.3
-
291
-
-
0036733646
-
Nonselenium glutathione peroxidase in human brain. Elevated levels in Parkinson's disease and dementia with Lewy bodies
-
Power J.H.T., Shannon J.M., Blumbergs P.C., Gai W.-P. Nonselenium glutathione peroxidase in human brain. Elevated levels in Parkinson's disease and dementia with Lewy bodies. American Journal of Pathology. 161:2002;885-894.
-
(2002)
American Journal of Pathology
, vol.161
, pp. 885-894
-
-
Power, J.H.T.1
Shannon, J.M.2
Blumbergs, P.C.3
Gai, W.-P.4
-
293
-
-
0035017068
-
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice
-
Rathke-Hartlieb S., Kahle P.J., Neumann M., Ozmen L., Haid S., Okochi M., et al. Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. Journal of Neurochemistry. 77:2001;1181-1184.
-
(2001)
Journal of Neurochemistry
, vol.77
, pp. 1181-1184
-
-
Rathke-Hartlieb, S.1
Kahle, P.J.2
Neumann, M.3
Ozmen, L.4
Haid, S.5
Okochi, M.6
-
294
-
-
0037189591
-
Synphilin-1 is developmentally localized to synaptic terminals and its association with synaptic vesicles is modulated by alpha-synuclein
-
Ribeiro C.S., Carneiro K., Ross C.A., Menezes J.R., Engelender S. Synphilin-1 is developmentally localized to synaptic terminals and its association with synaptic vesicles is modulated by alpha-synuclein. Journal of Biological Chemistry. 277:2002;23927-23933.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 23927-23933
-
-
Ribeiro, C.S.1
Carneiro, K.2
Ross, C.A.3
Menezes, J.R.4
Engelender, S.5
-
295
-
-
0036245056
-
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
-
Richfield E.K., Thiruchelvam M.J., Cory-Slechta D.A., Wuertzer C., Gainetdinov R.R., Caron M.G., et al. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Experimental Neurology. 175:2002;35-48.
-
(2002)
Experimental Neurology
, vol.175
, pp. 35-48
-
-
Richfield, E.K.1
Thiruchelvam, M.J.2
Cory-Slechta, D.A.3
Wuertzer, C.4
Gainetdinov, R.R.5
Caron, M.G.6
-
296
-
-
0034884622
-
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells
-
Rideout H.J., Larsen K.E., Sulzer D., Stefanis L. Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells. Journal of Neurochemistry. 78:2001;899-908.
-
(2001)
Journal of Neurochemistry
, vol.78
, pp. 899-908
-
-
Rideout, H.J.1
Larsen, K.E.2
Sulzer, D.3
Stefanis, L.4
-
297
-
-
0036432029
-
Proteasomal inhibition-induced inclusion formation and death incortical neurons require transcription and ubiquitination
-
Rideout H.J., Stefanis L. Proteasomal inhibition-induced inclusion formation and death incortical neurons require transcription and ubiquitination. Molecular and Cellular Neuroscience. 21:2002;223-238.
-
(2002)
Molecular and Cellular Neuroscience
, vol.21
, pp. 223-238
-
-
Rideout, H.J.1
Stefanis, L.2
-
298
-
-
0034609561
-
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein
-
Rochet J.C., Conway K.A., Lansbury P.T.J. Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry. 39:2000;10619-10626.
-
(2000)
Biochemistry
, vol.39
, pp. 10619-10626
-
-
Rochet, J.C.1
Conway, K.A.2
Lansbury, P.T.J.3
-
299
-
-
0035964758
-
Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease
-
Rockenstein E., Hansen L.A., Mallory M., Trojanowski J.Q., Galasko D., Masliah E. Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease. Brain Research. 914:2001;48-56.
-
(2001)
Brain Research
, vol.914
, pp. 48-56
-
-
Rockenstein, E.1
Hansen, L.A.2
Mallory, M.3
Trojanowski, J.Q.4
Galasko, D.5
Masliah, E.6
-
300
-
-
0037120274
-
A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: No evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish
-
Ross O.A., Awayn N.H., McWhinney D., Maxwell L.D., El-Agnaf O.M., Barnett Y.A., et al. A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish. Neuroreport. 13:2002;1621-1625.
-
(2002)
Neuroreport
, vol.13
, pp. 1621-1625
-
-
Ross, O.A.1
Awayn, N.H.2
McWhinney, D.3
Maxwell, L.D.4
El-Agnaf, O.M.5
Barnett, Y.A.6
-
301
-
-
0036171907
-
Parkinson's disease: The thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology
-
Rub U., Del T.K., Schultz C., Ghebremedhin E., de V.R., Jansen S.E., et al. Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology. Neurobiology of Aging. 23:2002;245-254.
-
(2002)
Neurobiology of Aging
, vol.23
, pp. 245-254
-
-
Rub, U.1
Del, T.K.2
Schultz, C.3
Ghebremedhin, E.4
De, V.R.5
Jansen, S.E.6
-
302
-
-
0033821703
-
Induction of neuronal death by alpha-synuclein
-
Saha A.R., Ninkina N.N., Hanger D.P., Anderton B.H., Davies A.M., Buchman V.L. Induction of neuronal death by alpha-synuclein. European Journal of Neuroscience. 12:2000;3073-3077.
-
(2000)
European Journal of Neuroscience
, vol.12
, pp. 3073-3077
-
-
Saha, A.R.1
Ninkina, N.N.2
Hanger, D.P.3
Anderton, B.H.4
Davies, A.M.5
Buchman, V.L.6
-
303
-
-
0034253913
-
Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course
-
Saito Y., Kawai M., Inoue K., Sasaki R., Arai H., Nanba E., et al. Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. Journal of the Neurological Sciences. 177:2000;48-59.
-
(2000)
Journal of the Neurological Sciences
, vol.177
, pp. 48-59
-
-
Saito, Y.1
Kawai, M.2
Inoue, K.3
Sasaki, R.4
Arai, H.5
Nanba, E.6
-
304
-
-
0031668027
-
Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity
-
Salter M.W. Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity. Biochemical Pharmacology. 56:1998;789-798.
-
(1998)
Biochemical Pharmacology
, vol.56
, pp. 789-798
-
-
Salter, M.W.1
-
305
-
-
0036934473
-
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: Immunohistochemical study in cases with alpha-synucleinopathies
-
Sasaki K., Doh-Ura K., Wakisaka Y., Iwaki T. Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. Acta Neuropathologica (Berlin). 104:2002;225-230.
-
(2002)
Acta Neuropathologica (Berlin)
, vol.104
, pp. 225-230
-
-
Sasaki, K.1
Doh-Ura, K.2
Wakisaka, Y.3
Iwaki, T.4
-
306
-
-
0034919135
-
Alpha-Synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors
-
Satoh J., Kuroda Y. alpha-Synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors. Parkinsonism and Related Disorders. 8:2001;7-17.
-
(2001)
Parkinsonism and Related Disorders
, vol.8
, pp. 7-17
-
-
Satoh, J.1
Kuroda, Y.2
-
307
-
-
0037096420
-
Cognitive slowing in Parkinson's disease: A behavioral evaluation independent of motor slowing
-
Sawamoto N., Honda M., Hanakawa T., Fukuyama H., Shibasaki H. Cognitive slowing in Parkinson's disease: a behavioral evaluation independent of motor slowing. Journal of Neuroscience. 22:2002;5198-5203.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 5198-5203
-
-
Sawamoto, N.1
Honda, M.2
Hanakawa, T.3
Fukuyama, H.4
Shibasaki, H.5
-
308
-
-
0036095285
-
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies
-
Schlossmacher M.G., Frosch M.P., Gai W.P., Medina M., Sharma N., Forno L., et al. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. American Journal of Pathology. 160:2002;1655-1667.
-
(2002)
American Journal of Pathology
, vol.160
, pp. 1655-1667
-
-
Schlossmacher, M.G.1
Frosch, M.P.2
Gai, W.P.3
Medina, M.4
Sharma, N.5
Forno, L.6
-
309
-
-
0030004466
-
Covergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders
-
Schmidt M.L., Martin J.A., Lee V.M., Trojanowski J.Q. Covergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathologica (Berlin). 91:1996;475-481.
-
(1996)
Acta Neuropathologica (Berlin)
, vol.91
, pp. 475-481
-
-
Schmidt, M.L.1
Martin, J.A.2
Lee, V.M.3
Trojanowski, J.Q.4
-
310
-
-
0035860983
-
Complete genomic screen in Parkinson disease: Evidence for multiple genes
-
Scott W.K., Nance M.A., Watts R.L., Hubble J.P., Koller W.C., Lyons K., et al. Complete genomic screen in Parkinson disease: evidence for multiple genes. Journal of the American Medical Association. 286:2002;2239-2244.
-
(2002)
Journal of the American Medical Association
, vol.286
, pp. 2239-2244
-
-
Scott, W.K.1
Nance, M.A.2
Watts, R.L.3
Hubble, J.P.4
Koller, W.C.5
Lyons, K.6
-
311
-
-
0036832421
-
α-Synuclein regulates neuronal survival via Bcl-2 family expression and Pi3/Akt kinase pathway
-
Seo J.-H., Rah J.-C., Choi S.H., Shin J.K., Min K., Kim H.-S. α-Synuclein regulates neuronal survival via Bcl-2 family expression and Pi3/Akt kinase pathway. FASEB Journal. 16:2002;1826-1828.
-
(2002)
FASEB Journal
, vol.16
, pp. 1826-1828
-
-
Seo, J.-H.1
Rah, J.-C.2
Choi, S.H.3
Shin, J.K.4
Min, K.5
Kim, H.-S.6
-
312
-
-
0034712918
-
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
-
Serpell L.C., Berriman J., Jakes R., Goedert M., Crowther R.A. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;4897-4902.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
313
-
-
0035404388
-
A close association of torsinA and alpha-synuclein in Lewy bodies: A fluorescence resonance energy transfer study
-
Sharma N., Hewett J., Ozelius L.J., Ramesh V., McLean P.J., Breakefield X.O., et al. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. American Journal of Pathology. 159:2001;339-344.
-
(2001)
American Journal of Pathology
, vol.159
, pp. 339-344
-
-
Sharma, N.1
Hewett, J.2
Ozelius, L.J.3
Ramesh, V.4
McLean, P.J.5
Breakefield, X.O.6
-
314
-
-
0035979233
-
Alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins
-
Sharon R., Goldberg M.S., Bar-Josef I., Betensky R.A., Shen J., Selkoe D.J. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;9110-9115.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 9110-9115
-
-
Sharon, R.1
Goldberg, M.S.2
Bar-Josef, I.3
Betensky, R.A.4
Shen, J.5
Selkoe, D.J.6
-
315
-
-
0037456578
-
The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon R., Bar-Joseph I., Frosch M.P., Walsh D.M., Hamilton J.A.,
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
Bar-Joseph, I.2
Frosch, M.P.3
Walsh, D.M.4
Hamilton, J.A.5
Selkoe, D.J.6
-
316
-
-
0034703336
-
TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease
-
Shashidharan P., Good P.F., Hsu A., Perl D.P., Brin M.F., Olanow C.W. TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease. Brain Research. 877:2002;379-381.
-
(2002)
Brain Research
, vol.877
, pp. 379-381
-
-
Shashidharan, P.1
Good, P.F.2
Hsu, A.3
Perl, D.P.4
Brin, M.F.5
Olanow, C.W.6
-
317
-
-
0037104723
-
An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
-
Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., et al. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. Journal of Neuroscience. 22:2002;7006-7015.
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 7006-7015
-
-
Sherer, T.B.1
Betarbet, R.2
Stout, A.K.3
Lund, S.4
Baptista, M.5
Panov, A.V.6
-
318
-
-
0037229425
-
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
-
Sherer T.B., Kim J.H., Betarbet R., Greenamyre J.T. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Experimental Neurology. 179:2003;9-16.
-
(2003)
Experimental Neurology
, vol.179
, pp. 9-16
-
-
Sherer, T.B.1
Kim, J.H.2
Betarbet, R.3
Greenamyre, J.T.4
-
319
-
-
0035139109
-
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
-
Sherman M.Y., Goldberg A.L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 29:2001;15-32.
-
(2001)
Neuron
, vol.29
, pp. 15-32
-
-
Sherman, M.Y.1
Goldberg, A.L.2
-
320
-
-
0034677207
-
Monoubiquitin carries a novel internalization signal that is appended to activated receptors
-
Shih S.C., Sloper-Mould K.E., Hicke L. Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO Journal. 19:2000;187-198.
-
(2000)
EMBO Journal
, vol.19
, pp. 187-198
-
-
Shih, S.C.1
Sloper-Mould, K.E.2
Hicke, L.3
-
321
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
-
Shimura H., Schlossmacher M.G., Hattori N., Frosch M.P., Trockenbacher A., Schneider R., et al. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science. 293:2001;263-269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.G.2
Hattori, N.3
Frosch, M.P.4
Trockenbacher, A.5
Schneider, R.6
-
322
-
-
0037414834
-
Ubiquitin-conjugation is not required for the degradation of oxidized proteins by the proteasome
-
Shringarpure R., Grune T., Mehlhase J., Davies K.J. Ubiquitin-conjugation is not required for the degradation of oxidized proteins by the proteasome. Journal of Biological Chemistry. 278:2002;311-318.
-
(2002)
Journal of Biological Chemistry
, vol.278
, pp. 311-318
-
-
Shringarpure, R.1
Grune, T.2
Mehlhase, J.3
Davies, K.J.4
-
323
-
-
0037177250
-
Molecular crowding accelerates fibrillization of alpha-synuclein: Could an increase in the cytoplasmic protein concentration induce Parkinson's disease?
-
Shtilerman M.D., Ding T.T., Lansbury P.T.J. Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease? Biochemistry. 41:2002;3855-3860.
-
(2002)
Biochemistry
, vol.41
, pp. 3855-3860
-
-
Shtilerman, M.D.1
Ding, T.T.2
Lansbury, P.T.J.3
-
324
-
-
0036164775
-
Autonomic dysfunction in Parkinson's disease: A comprehensive symptom survey
-
Siddiqui M.F., Rast S., Lynn M.J., Auchus A.P., Pfeiffer R.F. Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey. Parkinsonism and Related Disorders. 8:2002;277-284.
-
(2002)
Parkinsonism and Related Disorders
, vol.8
, pp. 277-284
-
-
Siddiqui, M.F.1
Rast, S.2
Lynn, M.J.3
Auchus, A.P.4
Pfeiffer, R.F.5
-
325
-
-
0038413759
-
Aggregated and monomeric α-synuclein bind to the S6′ proteasomal protein and inhibit proteasomal function
-
Snyder H., Mensah K., Theisler C., Lee J.M., Matouschek, Wolozin B. Aggregated and monomeric α-synuclein bind to the S6′ proteasomal protein and inhibit proteasomal function. Journal of Biological Chemistry. 278:2003;11753-11759.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 11753-11759
-
-
Snyder, H.1
Mensah, K.2
Theisler, C.3
Lee, J.M.4
Matouschek5
Wolozin, B.6
-
326
-
-
0035957367
-
An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease
-
Sobel N., Thomason M.E., Stappen I., Tanner C.M., Tetrud J.W., Bower J.M., et al. An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;4154-4159.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 4154-4159
-
-
Sobel, N.1
Thomason, M.E.2
Stappen, I.3
Tanner, C.M.4
Tetrud, J.W.5
Bower, J.M.6
-
327
-
-
0037228526
-
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitator for morphological evolution
-
Sollars V., Lu X., Xiao L., Wang X., Garfinkel M.D., Ruden D.M. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitator for morphological evolution. Nature Genetics. 33:2003;70-74.
-
(2003)
Nature Genetics
, vol.33
, pp. 70-74
-
-
Sollars, V.1
Lu, X.2
Xiao, L.3
Wang, X.4
Garfinkel, M.D.5
Ruden, D.M.6
-
330
-
-
0034674652
-
Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
-
Souza J.M., Giasson B.I., Chen Q., Lee V.M., Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. Journal of Biological Chemistry. 275:2000b;18344-18349.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 18344-18349
-
-
Souza, J.M.1
Giasson, B.I.2
Chen, Q.3
Lee, V.M.4
Ischiropoulos, H.5
-
331
-
-
0035789203
-
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
-
Specht C.G., Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neuroscience. 2:2001;11.
-
(2001)
BMC Neuroscience
, vol.2
, pp. 11
-
-
Specht, C.G.1
Schoepfer, R.2
-
332
-
-
0030882856
-
Alpha-Synuclein in Lewy bodies
-
Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. alpha-Synuclein in Lewy bodies. Nature. 388:1997;839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
333
-
-
0032584686
-
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Cairns N.J., Lantos P.L., Goedert M. Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neuroscience Letters. 251:1998a;205-208.
-
(1998)
Neuroscience Letters
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
334
-
-
0032568534
-
Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proceedings of the National Academy of Sciences of the United States of America. 95:1998b;6469-6473.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
336
-
-
0035894855
-
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
-
Stefanis L., Larsen K.E., Rideout H.J., Sulzer D., Greene L.A. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. Journal of Neuroscience. 21:2001;9549-9560.
-
(2001)
Journal of Neuroscience
, vol.21
, pp. 9549-9560
-
-
Stefanis, L.1
Larsen, K.E.2
Rideout, H.J.3
Sulzer, D.4
Greene, L.A.5
-
337
-
-
0034522723
-
Depression in alpha-synucleinopathies: Prevalence, pathophysiology and treatment
-
Stefanova N., Seppi K., Scherfler C., Puschban Z., Wenning G.K. Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment. Journal Neural Transmission Supplement. 60:2000;335-343.
-
(2000)
Journal Neural Transmission Supplement
, vol.60
, pp. 335-343
-
-
Stefanova, N.1
Seppi, K.2
Scherfler, C.3
Puschban, Z.4
Wenning, G.K.5
-
338
-
-
0035449454
-
Glial cell death induced by overexpression of alpha-synuclein
-
Stefanova N., Klimaschewski L., Poewe W., Wenning G.K., Reindl M. Glial cell death induced by overexpression of alpha-synuclein. Journal of Neuroscience Research. 65:2001;432-438.
-
(2001)
Journal of Neuroscience Research
, vol.65
, pp. 432-438
-
-
Stefanova, N.1
Klimaschewski, L.2
Poewe, W.3
Wenning, G.K.4
Reindl, M.5
-
339
-
-
0037134107
-
Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells
-
Stefanova N., Emgard M., Klimaschewski L., Wenning G.K., Reindl M. Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells. Neuroscience Letters. 323:2002;37-40.
-
(2002)
Neuroscience Letters
, vol.323
, pp. 37-40
-
-
Stefanova, N.1
Emgard, M.2
Klimaschewski, L.3
Wenning, G.K.4
Reindl, M.5
-
340
-
-
0034090632
-
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
-
Strickland E., Hakala K., Thomas P.J., DeMartino G.N. Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome. Journal of Biological Chemistry. 275:2000;5565-5572.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 5565-5572
-
-
Strickland, E.1
Hakala, K.2
Thomas, P.J.3
DeMartino, G.N.4
-
341
-
-
0033058534
-
Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent
-
Stumptner C., Heid H., Fuchsbichler A., Hauser H., Mischinger H.J., Zatloukal K., et al. Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent. American Journal of Pathology. 154:1999;1701-1710.
-
(1999)
American Journal of Pathology
, vol.154
, pp. 1701-1710
-
-
Stumptner, C.1
Heid, H.2
Fuchsbichler, A.3
Hauser, H.4
Mischinger, H.J.5
Zatloukal, K.6
-
342
-
-
0035920226
-
Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein
-
Sung J.Y., Kim J., Paik S.R., Park J.H., Ahn Y.S., Chung K.C. Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein. Journal of Biological Chemistry. 276:2001;27441-27448.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 27441-27448
-
-
Sung, J.Y.1
Kim, J.2
Paik, S.R.3
Park, J.H.4
Ahn, Y.S.5
Chung, K.C.6
-
344
-
-
0034965086
-
Biochemical analysis of cybrids expressing mitochondrial DNA from Contoursi kindred Parkinson's subjects
-
Swerdlow R.H., Parks J.K., Cassarino D.S., Binder D.R., Bennett J.P., Di Iorio G., et al. Biochemical analysis of cybrids expressing mitochondrial DNA from Contoursi kindred Parkinson's subjects. Experimental Neurology. 169:2001;479-485.
-
(2001)
Experimental Neurology
, vol.169
, pp. 479-485
-
-
Swerdlow, R.H.1
Parks, J.K.2
Cassarino, D.S.3
Binder, D.R.4
Bennett, J.P.5
Di Iorio, G.6
-
345
-
-
0034326816
-
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity
-
Tabrizi S.J., Orth M., Wilkinson J.M., Taanman J.W., Warner T.T., Cooper J.M., et al. Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity. Human Molecular Genetics. 9:2000;2683-2689.
-
(2000)
Human Molecular Genetics
, vol.9
, pp. 2683-2689
-
-
Tabrizi, S.J.1
Orth, M.2
Wilkinson, J.M.3
Taanman, J.W.4
Warner, T.T.5
Cooper, J.M.6
-
346
-
-
0028198309
-
Familial juvenile Parkinsonism: Clinical and pathologic study in a family
-
Takahashi H., Ohama E., Suzuki S., Horikawa Y., Ishikawa A., Morita T., et al. Familial juvenile Parkinsonism: clinical and pathologic study in a family. Neurology. 44:1994;437-441.
-
(1994)
Neurology
, vol.44
, pp. 437-441
-
-
Takahashi, H.1
Ohama, E.2
Suzuki, S.3
Horikawa, Y.4
Ishikawa, A.5
Morita, T.6
-
347
-
-
0035706436
-
The cellular pathology of Parkinson's disease
-
Takahashi H., Wakabayashi K. The cellular pathology of Parkinson's disease. Neuropathology. 21:2001;315-322.
-
(2001)
Neuropathology
, vol.21
, pp. 315-322
-
-
Takahashi, H.1
Wakabayashi, K.2
-
348
-
-
0034678823
-
Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease
-
Takahashi M., Iseki E., Kosaka K. Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease. Brain Research. 862:2000;253-256.
-
(2000)
Brain Research
, vol.862
, pp. 253-256
-
-
Takahashi, M.1
Iseki, E.2
Kosaka, K.3
-
349
-
-
0037205095
-
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress
-
Takahashi T., Yamashita H., Nakamura T., Nagano Y., Nakamura S. Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress. Brain Research. 938:2002a;73-80.
-
(2002)
Brain Research
, vol.938
, pp. 73-80
-
-
Takahashi, T.1
Yamashita, H.2
Nakamura, T.3
Nagano, Y.4
Nakamura, S.5
-
350
-
-
0037461582
-
Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila
-
Takahashi M., Kanuka H., Fujiwara H., Koyama A., Hasegawa M., Miura M., et al. Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila. Neuroscience Letters. 336:2002b;155-158.
-
(2002)
Neuroscience Letters
, vol.336
, pp. 155-158
-
-
Takahashi, M.1
Kanuka, H.2
Fujiwara, H.3
Koyama, A.4
Hasegawa, M.5
Miura, M.6
-
351
-
-
0031907128
-
Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders
-
Takeda A., Mallory M., Sundsmo M., Honer W., Hansen L., Masliah E. Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders. American Journal of Pathology. 152:1998;367-372.
-
(1998)
American Journal of Pathology
, vol.152
, pp. 367-372
-
-
Takeda, A.1
Mallory, M.2
Sundsmo, M.3
Honer, W.4
Hansen, L.5
Masliah, E.6
-
352
-
-
0035151038
-
Reduced neurite outgrowth and cell adhesion in neuronal cells transfected with human α-synuclein
-
Takenouchi T., Hashimoto M., Hsu L.J., Mackowski B., Rockenstein E., Mallory M., et al. Reduced neurite outgrowth and cell adhesion in neuronal cells transfected with human α-synuclein. Molecular and Cellular Neuroscience. 17:2001;141-150.
-
(2001)
Molecular and Cellular Neuroscience
, vol.17
, pp. 141-150
-
-
Takenouchi, T.1
Hashimoto, M.2
Hsu, L.J.3
Mackowski, B.4
Rockenstein, E.5
Mallory, M.6
-
353
-
-
0037150751
-
Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels
-
Tamo W., Imaizumi T., Tanji K., Yoshida H., Mori F., Yoshimoto M., et al. Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels. Neuroscience Letters. 326:2002;5-8.
-
(2002)
Neuroscience Letters
, vol.326
, pp. 5-8
-
-
Tamo, W.1
Imaizumi, T.2
Tanji, K.3
Yoshida, H.4
Mori, F.5
Yoshimoto, M.6
-
354
-
-
0034646346
-
Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?
-
Tan E.K., Matsuura T., Nagamitsu S., Khajavi M., Jankovic J., Ashizawa T. Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor? Neurology. 54:2000;1195-1198.
-
(2000)
Neurology
, vol.54
, pp. 1195-1198
-
-
Tan, E.K.1
Matsuura, T.2
Nagamitsu, S.3
Khajavi, M.4
Jankovic, J.5
Ashizawa, T.6
-
355
-
-
0037426704
-
Alpha-Syncuclein promoter and risk of Parkinson's disease: Microsatellite and allelic size variability
-
Tan E.K., Tan C., Shen H., Chai A., Lum S.Y., Teoh M.L., et al. alpha-Syncuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability. Neuroscience Letters. 336:2003;70-72.
-
(2003)
Neuroscience Letters
, vol.336
, pp. 70-72
-
-
Tan, E.K.1
Tan, C.2
Shen, H.3
Chai, A.4
Lum, S.Y.5
Teoh, M.L.6
-
356
-
-
0035870881
-
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
-
Tanaka Y., Engelender S., Igarashi S., Rao R.K., Wanner T., Tanzi R.E., et al. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Human Molecular Genetics. 10:2001;919-926.
-
(2001)
Human Molecular Genetics
, vol.10
, pp. 919-926
-
-
Tanaka, Y.1
Engelender, S.2
Igarashi, S.3
Rao, R.K.4
Wanner, T.5
Tanzi, R.E.6
-
357
-
-
0035800223
-
Expression of alpha-synuclein in a human glioma cell line and its upregulation by interleukin-1beta
-
Tanji K., Imaizumi T., Yoshida H., Mori F., Yoshimoto M., Satoh K., et al. Expression of alpha-synuclein in a human glioma cell line and its upregulation by interleukin-1beta. Neuroreport. 12:2001;1909-1912.
-
(2001)
Neuroreport
, vol.12
, pp. 1909-1912
-
-
Tanji, K.1
Imaizumi, T.2
Yoshida, H.3
Mori, F.4
Yoshimoto, M.5
Satoh, K.6
-
358
-
-
18744395468
-
Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages
-
Tanji K., Mori F., Imaizumi T., Yoshida H., Matsumiya T., Tamo W., et al. Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages. Pathology International. 52:2002;572-577.
-
(2002)
Pathology International
, vol.52
, pp. 572-577
-
-
Tanji, K.1
Mori, F.2
Imaizumi, T.3
Yoshida, H.4
Matsumiya, T.5
Tamo, W.6
-
359
-
-
0034671469
-
The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease
-
Thiruchelvam M., Richfield E.K., Baggs R.B., Tank A.W., Cory-Slechta D.A. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. Journal of Neuroscience. 20:2000;9207-9214.
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 9207-9214
-
-
Thiruchelvam, M.1
Richfield, E.K.2
Baggs, R.B.3
Tank, A.W.4
Cory-Slechta, D.A.5
-
360
-
-
0035976835
-
Alpha-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
Tofaris G.K., Layfield R., Spillantini M.G. alpha-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Letters. 509:2001;22-26.
-
(2001)
FEBS Letters
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
Layfield, R.2
Spillantini, M.G.3
-
361
-
-
0035864974
-
Glial involvement in the degeneration process of Lewy body-bearing neurons and the degredation process of Lewy bodies in brains of dementia with Lewy bodies
-
Togo T., Iseki E., Marui W., Akiyama H., Ueda K., Kosaka K. Glial involvement in the degeneration process of Lewy body-bearing neurons and the degredation process of Lewy bodies in brains of dementia with Lewy bodies. Journal of the Neurological Sciences. 184:2001;71-75.
-
(2001)
Journal of the Neurological Sciences
, vol.184
, pp. 71-75
-
-
Togo, T.1
Iseki, E.2
Marui, W.3
Akiyama, H.4
Ueda, K.5
Kosaka, K.6
-
362
-
-
0035026044
-
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1
-
Torres G.E., Yao W.D., Mohn A.R., Quan H., Kim K.M., Levey A.I., et al. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 30:2001;121-134.
-
(2001)
Neuron
, vol.30
, pp. 121-134
-
-
Torres, G.E.1
Yao, W.D.2
Mohn, A.R.3
Quan, H.4
Kim, K.M.5
Levey, A.I.6
-
363
-
-
0035153594
-
Human and mouse alpha-synuclein genes: Comparative genomic sequence analysis and identification of a novel gene regulatory element
-
Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E., Schwartz J.R., Orrison B.M., et al. Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. Genome Research. 11:2001;78-86.
-
(2001)
Genome Research
, vol.11
, pp. 78-86
-
-
Touchman, J.W.1
Dehejia, A.2
Chiba-Falek, O.3
Cabin, D.E.4
Schwartz, J.R.5
Orrison, B.M.6
-
365
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90:1993;11282-11286.
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, pp. 11282-11286
-
-
Ueda, K.1
Fukushima, H.2
Masliah, E.3
Xia, Y.4
Iwai, A.5
Yoshimoto, M.6
-
366
-
-
1842832448
-
14-3-3 is a component of Lewy bodies in Parkinson's disease - Mutation analysis and association studies of 14-3-3 eta
-
Uhl A., Berg D., Holzmann C., Kruger R., Berger K., Arzberger T., et al. 14-3-3 is a component of Lewy bodies in Parkinson's disease - mutation analysis and association studies of 14-3-3 eta. Brain Research. 108:2002;33-39.
-
(2002)
Brain Research
, vol.108
, pp. 33-39
-
-
Uhl, A.1
Berg, D.2
Holzmann, C.3
Kruger, R.4
Berger, K.5
Arzberger, T.6
-
367
-
-
0037014618
-
Amino acid determinants of alpha-synuclein aggregation: Putting together pieces of the puzzle
-
Uversky V.N., Fink A.L. Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle. FEBS Letters. 522:2002;9-13.
-
(2002)
FEBS Letters
, vol.522
, pp. 9-13
-
-
Uversky, V.N.1
Fink, A.L.2
-
368
-
-
0035815664
-
Evidence for a partially folded intermediate in alpha-synuclein fibril formation
-
Uversky V.N., Li J., Fink A.L. Evidence for a partially folded intermediate in alpha-synuclein fibril formation. Journal of Biological Chemistry. 276:2001a;10737-10744.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 10737-10744
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
369
-
-
0035941305
-
Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations
-
Uversky V.N., Lee H.J., Li J., Fink A.L., Lee S.J. Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations. Journal of Biological Chemistry. 276:2001b;43495-43498.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 43495-43498
-
-
Uversky, V.N.1
Lee, H.J.2
Li, J.3
Fink, A.L.4
Lee, S.J.5
-
370
-
-
0035976814
-
Trimethylamine-N-oxide-induced folding of alpha-synuclein
-
Uversky V.N., Li J., Fink A.L. Trimethylamine-N-oxide-induced folding of alpha-synuclein. FEBS Letters. 509:2001c;31-35.
-
(2001)
FEBS Letters
, vol.509
, pp. 31-35
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
371
-
-
0035941201
-
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure
-
Uversky V.N., Li J., Fink A.L. Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. Journal of Biological Chemistry. 276:2001d;44284-44296.
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 44284-44296
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
372
-
-
0035816404
-
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: A possible factor in Parkinson's disease
-
Uversky V.N., Li J., Fink A.L. Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Letters. 500:2001e;105-108.
-
(2001)
FEBS Letters
, vol.500
, pp. 105-108
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
373
-
-
0037165646
-
Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro
-
Uversky V.N., Yamin G., Souillac P.O., Goers J., Glaser C.B., Fink A.L. Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro. FEBS Letters. 517:2002a;239-244.
-
(2002)
FEBS Letters
, vol.517
, pp. 239-244
-
-
Uversky, V.N.1
Yamin, G.2
Souillac, P.O.3
Goers, J.4
Glaser, C.B.5
Fink, A.L.6
-
374
-
-
0037181497
-
Accelerated alpha-synuclein fibrillation in crowded milieu
-
Uversky V.N., Cooper M., Bower K.S., Li J., Fink A.L. Accelerated alpha-synuclein fibrillation in crowded milieu. FEBS Letters. 515:2002b;99-103.
-
(2002)
FEBS Letters
, vol.515
, pp. 99-103
-
-
Uversky, V.N.1
Cooper, M.2
Bower, K.S.3
Li, J.4
Fink, A.L.5
-
375
-
-
0037023699
-
Biophysical properties of the synucleins and their propensities to fibrillate
-
Uversky V.N., Li J., Souillac P., Millett I.S., Doniach S., Jakes R., et al. Biophysical properties of the synucleins and their propensities to fibrillate. Journal of Biological Chemistry. 277:2002c;11970-11978.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 11970-11978
-
-
Uversky, V.N.1
Li, J.2
Souillac, P.3
Millett, I.S.4
Doniach, S.5
Jakes, R.6
-
376
-
-
0035068574
-
Localization of a novel locus for autosomal recessive early-onset Parkinsonism, PARK6, on human chromosome 1p35-p36
-
Valente E.M., Bentivoglio A.R., Dixon P.H., Ferraris A., Ialongo T., Frontali M., et al. Localization of a novel locus for autosomal recessive early-onset Parkinsonism, PARK6, on human chromosome 1p35-p36. American Journal of Human Genetics. 68:2001;895-900.
-
(2001)
American Journal of Human Genetics
, vol.68
, pp. 895-900
-
-
Valente, E.M.1
Bentivoglio, A.R.2
Dixon, P.H.3
Ferraris, A.4
Ialongo, T.5
Frontali, M.6
-
377
-
-
0034663176
-
Neuropathology in mice expressing human α-synuclein
-
van der Putten H., Wiederhold K.-H., Probst A., Barbieri S., Mistl C., Danner S., et al. Neuropathology in mice expressing human α-synuclein. Journal of Neuroscience. 20:2000;6021-6029.
-
(2000)
Journal of Neuroscience
, vol.20
, pp. 6021-6029
-
-
Van der Putten, H.1
Wiederhold, K.-H.2
Probst, A.3
Barbieri, S.4
Mistl, C.5
Danner, S.6
-
378
-
-
0038460778
-
Gaucher disease associated with parkinsonism: Four further case reports
-
Varkonyi J., Rosenbaum H., Baumann N., MacKenzie J.J., Simon Z., Aharon-Peretz J., et al. Gaucher disease associated with parkinsonism: four further case reports. American Journal of Medical Genetics A. 116:2003;348-351.
-
(2003)
American Journal of Medical Genetics A
, vol.116
, pp. 348-351
-
-
Varkonyi, J.1
Rosenbaum, H.2
Baumann, N.3
MacKenzie, J.J.4
Simon, Z.5
Aharon-Peretz, J.6
-
379
-
-
0033966487
-
Alpha-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
-
Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., Jakowec M., Przedborski S. alpha-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. Journal of Neurochemistry. 74:2000;721-729.
-
(2000)
Journal of Neurochemistry
, vol.74
, pp. 721-729
-
-
Vila, M.1
Vukosavic, S.2
Jackson-Lewis, V.3
Neystat, M.4
Jakowec, M.5
Przedborski, S.6
-
380
-
-
0037046163
-
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
-
Volles M.J., Lansbury P.T.J. Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry. 41:2002;4595-4602.
-
(2002)
Biochemistry
, vol.41
, pp. 4595-4602
-
-
Volles, M.J.1
Lansbury, P.T.J.2
-
381
-
-
0035800097
-
Vesicle permeabilization by protofibrillar alpha-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease
-
Volles M.J., Lee S.J., Rochet J.C., Shtilerman M.D., Ding T.T., Kessler J.C., Lansbury P.T. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry. 40:2001;7812-7819.
-
(2001)
Biochemistry
, vol.40
, pp. 7812-7819
-
-
Volles, M.J.1
Lee, S.J.2
Rochet, J.C.3
Shtilerman, M.D.4
Ding, T.T.5
Kessler, J.C.6
Lansbury, P.T.7
-
382
-
-
0031566042
-
NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
-
Wakabayashi K., Matsumoto K., Takayama K., Yoshimoto M., Takahashi H. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neuroscience Letters. 239:1997;45-48.
-
(1997)
Neuroscience Letters
, vol.239
, pp. 45-48
-
-
Wakabayashi, K.1
Matsumoto, K.2
Takayama, K.3
Yoshimoto, M.4
Takahashi, H.5
-
383
-
-
0034085796
-
Synphilin-1 is present in Lewy bodies in Parkinson's disease
-
Wakabayashi K., Engelender S., Yoshimoto M., Tsuji S., Ross C.A., Takahashi H. Synphilin-1 is present in Lewy bodies in Parkinson's disease. Annals of Neurology. 47:2000;521-523.
-
(2000)
Annals of Neurology
, vol.47
, pp. 521-523
-
-
Wakabayashi, K.1
Engelender, S.2
Yoshimoto, M.3
Tsuji, S.4
Ross, C.A.5
Takahashi, H.6
-
384
-
-
0036938071
-
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders
-
Wakabayashi K., Engelender S., Tanaka Y., Yoshimoto M., Mori F., Tsuji S., et al. Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathologica (Berlin). 103:2002;209-214.
-
(2002)
Acta Neuropathologica (Berlin)
, vol.103
, pp. 209-214
-
-
Wakabayashi, K.1
Engelender, S.2
Tanaka, Y.3
Yoshimoto, M.4
Mori, F.5
Tsuji, S.6
-
385
-
-
0030799122
-
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh D.M., Lomakin A., Benedek G.B., Condron M.M., Teplow D.B. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. Journal of Biological Chemistry. 272:1997;22364-22372.
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
Condron, M.M.4
Teplow, D.B.5
-
386
-
-
0033520461
-
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
-
Walsh D.M., Hartley D.M., Kusumoto Y., Fezoui Y., Condron M.M., Lomakin A., et al. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. Journal of Biological Chemistry. 274:1999;25945-25952.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 25945-25952
-
-
Walsh, D.M.1
Hartley, D.M.2
Kusumoto, Y.3
Fezoui, Y.4
Condron, M.M.5
Lomakin, A.6
-
387
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416:2002;535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
388
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb P.H., Zhen W., Poon A.W., Conway K.A., Lansbury P.T.J. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry. 35:1996;13709-13715.
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.J.5
-
389
-
-
0036842130
-
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease
-
Wilson S.M., Bhattacharyya B., Rachel R.A., Coppola V., Tessarollo L., Householder D.B., et al. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nature Genetics. 32:2002;420-425.
-
(2002)
Nature Genetics
, vol.32
, pp. 420-425
-
-
Wilson, S.M.1
Bhattacharyya, B.2
Rachel, R.A.3
Coppola, V.4
Tessarollo, L.5
Householder, D.B.6
-
390
-
-
0036670331
-
Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides
-
Windisch M., Hutter-Paier B., Rockenstein E., Hashimoto M., Mallory M., Masliah E. Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides. Journal of Molecular Neuroscience. 19:2002;63-69.
-
(2002)
Journal of Molecular Neuroscience
, vol.19
, pp. 63-69
-
-
Windisch, M.1
Hutter-Paier, B.2
Rockenstein, E.3
Hashimoto, M.4
Mallory, M.5
Masliah, E.6
-
391
-
-
0034722590
-
Lewy body variant of Alzheimer's disease: Alpha-synuclein in dystrophic neurites of A beta plaques
-
Wirths O., Weickert S., Majtenyi K., Havas L., Kahle P.J., Okochi M., et al. Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. Neuroreport. 11:2000;3737-3741.
-
(2000)
Neuroreport
, vol.11
, pp. 3737-3741
-
-
Wirths, O.1
Weickert, S.2
Majtenyi, K.3
Havas, L.4
Kahle, P.J.5
Okochi, M.6
-
392
-
-
0033538541
-
Alpha-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
-
Wood S.J., Wypych J., Steavenson S., Louis J.C., Citron M., Biere A.L. alpha-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. Journal of Biological Chemistry. 274:1999;19509-19512.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.C.4
Citron, M.5
Biere, A.L.6
-
393
-
-
0034755275
-
Characterization of the human alpha-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphisms
-
Xia Y., Saitoh T., Ueda K., Tanaka S., Chen X., Hashimoto M., et al. Characterization of the human alpha-synuclein gene: genomic structure, transcription start site, promoter region and polymorphisms. Journal of Alzheimer's Disease. 3:2001;485-494.
-
(2001)
Journal of Alzheimer's Disease
, vol.3
, pp. 485-494
-
-
Xia, Y.1
Saitoh, T.2
Ueda, K.3
Tanaka, S.4
Chen, X.5
Hashimoto, M.6
-
394
-
-
0036278335
-
Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
-
Xu J., Kao S.Y., Lee F.J., Song W., Jin L.W., Yankner B.A. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nature Medicine. 8:2002;600-606.
-
(2002)
Nature Medicine
, vol.8
, pp. 600-606
-
-
Xu, J.1
Kao, S.Y.2
Lee, F.J.3
Song, W.4
Jin, L.W.5
Yankner, B.A.6
-
395
-
-
0037138389
-
How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis
-
Yaffe M.B. How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Letters. 513:2002;53-57.
-
(2002)
FEBS Letters
, vol.513
, pp. 53-57
-
-
Yaffe, M.B.1
-
396
-
-
0033936784
-
Alpha-Synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam
-
Yamazaki M., Arai Y., Baba M., Iwatsubo T., Mori O., Katayama Y., et al. alpha-Synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam. Journal of Neuropathology and Experimental Neurology. 59:2000;585-591.
-
(2000)
Journal of Neuropathology and Experimental Neurology
, vol.59
, pp. 585-591
-
-
Yamazaki, M.1
Arai, Y.2
Baba, M.3
Iwatsubo, T.4
Mori, O.5
Katayama, Y.6
-
397
-
-
0036938527
-
NACP/α-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC)
-
Yokota O., Terada S., Ishizu H., Tsuchiya K., Kitamura Y., Ikeda K., et al. NACP/α-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathologica. 104:2002;333-341.
-
(2002)
Acta Neuropathologica
, vol.104
, pp. 333-341
-
-
Yokota, O.1
Terada, S.2
Ishizu, H.3
Tsuchiya, K.4
Kitamura, Y.5
Ikeda, K.6
-
398
-
-
0029056115
-
NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation
-
Yoshimoto M., Iwai A., Kang D., Otero D.A., Xia Y., Saitoh T. NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation. Proceedings of the National Academy of Sciences of the United States of America. 92:1995;9141-9145.
-
(1995)
Proceedings of the National Academy of Sciences of the United States of America
, vol.92
, pp. 9141-9145
-
-
Yoshimoto, M.1
Iwai, A.2
Kang, D.3
Otero, D.A.4
Xia, Y.5
Saitoh, T.6
-
399
-
-
0037192427
-
6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats
-
Zeng B.Y., Dass B., Owen A., Rose S., Cannizzaro C., Tel B.C., et al. 6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats. Neuroscience Letters. 322:2002;33-36.
-
(2002)
Neuroscience Letters
, vol.322
, pp. 33-36
-
-
Zeng, B.Y.1
Dass, B.2
Owen, A.3
Rose, S.4
Cannizzaro, C.5
Tel, B.C.6
-
400
-
-
0034700158
-
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
-
Zhang Y., Gao J., Chung K.K., Huang H., Dawson V.L., Dawson T.M. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;13354-13359.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 13354-13359
-
-
Zhang, Y.1
Gao, J.2
Chung, K.K.3
Huang, H.4
Dawson, V.L.5
Dawson, T.M.6
-
401
-
-
0034608824
-
Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: Synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions
-
Zhao W., Cavallaro S., Gusev P., Alkon D.L. Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;8098-8103.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 8098-8103
-
-
Zhao, W.1
Cavallaro, S.2
Gusev, P.3
Alkon, D.L.4
-
402
-
-
0036468957
-
Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture
-
Zhou W., Schaack J., Zawada W.M., Freed C.R. Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture. Brain Research. 926:2002;42-50.
-
(2002)
Brain Research
, vol.926
, pp. 42-50
-
-
Zhou, W.1
Schaack, J.2
Zawada, W.M.3
Freed, C.R.4
|