Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 13, 1998, Pages 7659-7663

  Ara, Jahan ^a   Przedborski, Serge ^b   Naini, Ali B ^b   Jackson Lewis, Vernice ^b   Trifiletti, Rosario R ^c   Horwitz, Joel ^a   Ischiropoulos, Harry ^d  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; PEROXYNITRITE; SUPEROXIDE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORPUS STRIATUM; DOPAMINE METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; MALE; NITRATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; TISSUE LEVEL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; MICE; NITRATES; PC12 CELLS; RATS; SUPEROXIDE DISMUTASE; TYROSINE 3-MONOOXYGENASE;

ANIMALIA;

EID: 0032560486     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.13.7659     Document Type: Article

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