Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation

Journal of Biological Chemistry

Volumn 273, Issue 41, 1998, Pages 26292-26294

  Jensen, Poul H ^a,b   Nielsen, Morten S ^a   Jakes, Ross ^c   Dotti, Carlos G ^b   Goedert, Michel ^c  

^a AARHUS UNIVERSITY   (Denmark)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BRAIN PROTEIN; MUTANT PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; DEMENTIA; FAMILIAL DISEASE; FEMALE; LEWY BODY; MEMBRANE VESICLE; MISSENSE MUTATION; NERVE FIBER TRANSPORT; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; RAT; VISUAL SYSTEM;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; ANIMALS; AXONS; BRAIN; FEMALE; LEWY BODIES; MUTATION; NERVE TISSUE PROTEINS; OPTIC NERVE; PARKINSON DISEASE; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; SYNUCLEINS;

ANIMALIA;

EID: 0032500599     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.41.26292     Document Type: Article

References (21)

1. Forno, L. S. (1996) J. Neuropathol. Exp. Neurol. 55, 259-272
2. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehijia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
3. Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J., Schöls, L., and Riess, O. (1998) Nat. Genet. 18, 106-108
4. Goedert, M., Jakes, R., and Spillantini, M. G. (1998) NeuroSci. News 1, 2-6
5. Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
6. Baba, M., Nakajo, S., Tu, P.-H., Tomita, T., Nakaya, K., Lee, V. M.-Y., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
7. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6469-6473
8. Ince, P. G., Perry, E. K., and Morris, C. M. (1998) Brain Pathol. 8, 299-324
9. Hirokawa, N. (1998) Science 279, 519-526
10. Brady, S. T. (1985) in Neuromethods (Boulton, A. A., and Baker, G. B., eds) Vol. 1, pp. 419-459, Humana Press, Clifton Park, NJ
11. Brown, D. A., and Rose, J. K (1992) Cell 68, 533-544
12. Jakes, R., Spillantini, M. G., and Goedert, M. (1994) FEBS Lett. 345, 27-32
13. Nakajo, S., Tsukada, K., Omata, K, Nakamura, Y., and Nakaya, K. (1993) Eur. J. Biochem. 217, 1057-1063
14. Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988) J. Neurosci. 8, 2804-2815
15. Maroteaux, L., and Scheller, R. H. (1991) Mol. Brain Res. 11, 335-343
16. Uéda, K, Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A. C., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11282-11286
17. George, J. M., Jin, H., Woods, W. S., and Clayton, D. F (1995) Neuron 15, 361-372
18. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) J. Biol. Chem. 273, 9443-9449
19. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T. (1996) Biochemistry 35, 13709-13715
20. Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., and Saitoh, T. (1995) Neuron 14, 467-475
21. Irizarry, M. C., Kim, T.-W., McNara, M., Tanzi, R. E., George, J., Clayton, D. F., and Hyman, B. T. (1996) J. Neuropathol. Exp. Neurol. 55, 889-895