Biochemical analysis of cybrids expressing mitochondrial DNA from Contursi kindred Parkinson's subjects

Experimental Neurology

Volumn 169, Issue 2, 2001, Pages 479-485

  Swerdlow, Russell H ^a   Parks, Janice K ^a   Cassarino, David S ^a   Binder, Daniel R ^a   Bennett Jr , James P ^a   Di Iorio, Giuseppe ^c   Golbe, Lawrence I ^b   Parker Jr , W Davis ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Cybrids; Mitochondria; Mitochondrial DNA; Oxidative stress; Parkinson's disease; synuclein

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; ITALY; MALE; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0034965086     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7674     Document Type: Article

References (48)

1. Complex I defect in muscle from patients with Huntington's disease
2. Aging, energy, and oxidative stress in neurodegenerative diseases
3. Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes
4. Regional mitochondrial respiratory activity in Huntington's disease brain
5. Oxidative damage and metabolic dysfunction in Huntingtons disease - Selective vulnerability of the basal ganglia
6. Mitochondried abnormalities in non-alcoholic steatohepatitis
7. Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion
8. Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease
9. ly8 mutation casusing myoclonic epilepsy and ragged red fibers
10. A chromosome 4p haplotype segregating with Parkinson's disease and postured tremor
11. A susceptibility locus for Parkinson's disease maps to chromosome 2p13
12. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
13. A large kindred with autosomal dominant Parkinson's disease
14. Mitochondrial defect in Huntington's disease caudate nucleus
15. Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease
16. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
17. Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients
18. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
19. Enhanced vulnerability to α-synuclein mutations and C-terminal truncation
20. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complemetation
21. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
22. Sensitization of neuronal cells to oxidative stress with mutated human α-synculein
23. Platelet mitochondrial function in Parkinson's disease: The Royal Kings and Queens Parkinson Disease Research Group
24. Ala30Pro mutation in the gene encoding a-synuclein in Parkinson's disease
25. The ubiquitin pathway in Parkinson's disease
26. Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia
27. Membrane association and protein conformation of alpha-synuclein in intact neurons: Effect of Parkinson's disease-linked mutations
28. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
29. Creation and characterization of mitochondrial DNA depleted cell lines with "neuronal-like" properties
30. Electron transport chain abnormalities in idiopathic Parkinson's disease
31. Evidence for a defect in NADH: Ubiquinone oxidoreductase (complex I) in Huntington's disease
32. Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
33. Mutation in the a-synuclein gene identified in families with Parkinson's disease
34. Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity
35. Oxidative post-translational modifications of a-synuclein n the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
36. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
37. Reduced complex I activity in parkinsonian cybrids
38. Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation
39. Dityrosine cross-linking promotes formation of stable α-synuclein polymers
40. Origin and funtional consequences of the complex I defect in Parkinson's disease
41. Cybrids in Alzheimer's disease: A cellular model of the disease?
42. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family
43. Mitochondria in sporadic amyotrophic lateral sclerosis
44. Characterization of cybrid cell lines containing mtDNA from Huntington's disease patients
45. Mitochondrial dysfunction in cybrid lines expressing mitochondrial genes from patients with PSP
46. A novel T1095C mutation in the mitochondrial 12s ribosomal RNA gene
47. Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines
48. Mitochondrial complex I and II activities oflymphocytes and platelets in Parkinson's disease