α-Synuclein shares physical and functional homology with 14-3-3 proteins

Journal of Neuroscience

Volumn 19, Issue 14, 1999, Pages 5782-5791

  Ostrerova, Natalie ^a   Petrucelli, Leonard ^a   Farrer, Matthew ^b   Mehta, Nitinkumar ^b   Choi, Peter ^a   Hardy, John ^b   Wolozin, Benjamin ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

14 3 3 proteins; Alzheimer's disease; Apoptosis; BAD; Extracellular regulated kinase; Parkinson's disease; Protein kinase C; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; BRAIN PROTEIN; CHAPERONE; PROTEIN KINASE C;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME INHIBITION; HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

EID: 0033565874     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-14-05782.1999     Document Type: Article

References (39)

1. Aitken A, Howell S, Jones D, Madrazo J, Martin H, Patel Y, Robinson K (1995) Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C. Mol Cell Biochem 149:41-49.
2. Atwood C, Moir R, Huang X, Scarpa R, Bacarra N, Romano D, Hartshorn M, Tanzi R, Bush A (1998) Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem 273:12817-12826.
3. Behl C, Davis J, Klier F, Schubert D (1994) Amyloid β peptide induces necrosis rather than apoptosis. Brain Res 645:253-264.
4. Broadie K, Rushton E, Skoulakis E, Davis R (1997) Leonardo, a Drosophila 14-3-3 protein involved in learning, regulates presynaptic function. Neuron 19:391-402.
5. Clayton D, George J (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21:249-254.
6. Conway K, Harper J, Lansbury P (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease. Nature Med 4:1318-1320.
7. Corpet F (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 16:10881-10890.
8. Davidson W, Jonas A, Clayton D, George J (1998) Stabilization of α-synuclein secondary structure on binding to synthetic membranes. J Biol Chem 273:9443-9449.
9. Dubois T, Howell S, Amess B, Kerai P, Learmonth M, Madrazo J, Chaudhri M, Rittinger K, Scarabel M, Soneji Y, Aitken A (1997) Structure and sites of phosphorylation of 14-3-3 protein: role in coordinating signal transduction pathways. J Protein Chem 16:513-522.
10. El-Agnaf O, Jakes R, Curran M, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A (1998a) Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments. FEBS Lett 440:71-75.
11. El-Agnaf O, Jakes R, Curran M, Wallace A (1998b) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease. FEBS Lett 440:67-70.
12. George JM, Jin H, Woods WS, Clayton DF (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15:361-372.
13. Hashimoto M, Hsu L, Sisk A, Xia Y, Takeda A, Sundsmo M, Masliah E (1998) Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Brain Res 799:301-306.
14. Hunot S, Brugg B, Ricard D, Michel P, Muriel M, Ruberg M, Faucheux B, Agid Y, Hirsch E (1997) Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson's disease. Proc Natl Acad Sci USA 94:7531-7536.
15. Ichimura T, Ito M, Itagaki C, Takahashi M, Horigome T, Omata S, Ohno S, Isobe T (1997) The 14-3-3 protein binds its target proteins with a common site located towards the C-terminus. FEBS Lett 413:273-276.
16. Jakes R, Spillantini M, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345:27-32.
17. Jenco J, Rawlingson A, Daniels B, Morris A (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by α and β synucleins. Biochemistry 37:4901-4909.
18. Jensen P, Nielsen M, Jakes R, Dotti C, Goedert M (1998) Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J Biol Chem 273:26292-26294.
19. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen J, Schols L, Riess O (1998) A1a30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat Genet 18:106-108.
20. Layfield R, Fergusson J, Aitken A, Lowe J, Landon M, Mayer R (1996) Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neurosci Lett 209:57-60.
21. Lu Y, Tremblay R, Jouishomme H, Chakravarthy B, Durkin JP (1994) Evidence that the activation of an inactive pool of membrane-associated protein kinase C is linked to the IL-2-dependent survival of T lymphocytes. J Immunol 153:1495-1504.
22. Matto-Yelin M, Aitken A, Ravid S (1997) 14-3-3 inhibits the dictyostelium mysoin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain. Mol Biol Cell 8:1889-1899.
23. Meller N, Liu YC, Collins TL, Bonnefoy-Berard N, Baier G, Isakov N, Altman A (1996) Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. Mol Cell Biol 16:5782-5791.
24. Mochly-Rosen D, Kauvlar L (1998) Modulating protein kinase C signal transduction. Adv Pharmacol 44:91-145.
25. Muslin A, Tanner J, Allen P, Shaw A (1996) Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84:889-897.
26. Paik SR, Lee JH, Kim DH, Chang CS, Kim YS (1998) Self-oligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (A β) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal A β fragment (residues 25-35). FEBS Lett 421:73-76.
27. Polymeropoulos M, Higgins J, Golbe L, Johnson W, Ide S, Di Iorio G, Sanges G, Stenroos E, Pho L, Schaffer A, Lazzarini A, Nussbaum R, Duvoisin R (1997) Mapping of a gene for Parkinson's disease to chromosome 4q21-q23. Science 1197-1199.
28. Reurther G, Pendergast M (1996) The roles of 14-3-3 proteins in signal transduction. Vitam Horm 52:149-175.
29. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95:6469-6473.
30. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E (1998) Abnormal accumulation of NACP/-synuclein in neurodegenerative disorders. Am J Pathol 152:367-372.
31. Tu P, Galvin J, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski J, Lee V (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44:415-422.
32. Tzivion G, Luo Z, Avruch J (1998) A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394:88-92.
33. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero D, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease. Proc Natl Acad Sci USA 90:11282-11286.
34. Weinreb P, Zhen W, Poon A, Conway K, Lansbury P (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35:13709-13715.
35. Wheeler-Jones C, Learmonth M, Martin H, Aitken A (1996) Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation. Biochem J 315:41-47.
36. Yaffe M, Rittinger K, Volinia S, Caron P, Aitken A, Leffers H, Gamblin S, Smerdon S, Cantley L (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 91:961-971.
37. Yan S, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt A (1996) RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691.
38. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291.
39. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628.