A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2380-2386

  Giasson, Benoit I ^b   Murray, Ian V J ^b   Trojanowski, John Q ^b   Lee, Virginia M Y ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; DISEASES; HYDROPHOBICITY; POLYMERIZATION;

FIBRILLIZATION;

NEUROLOGY;

ALPHA SYNUCLEIN; AMINO ACID; UNCLASSIFIED DRUG; VALYLTHREONYLGLYCYLVALYLTHREONYLALANYLVALYLALANYLGLUTAMINYLLYSYLTHREONYLVAL INE; BETA SYNUCLEIN; NERVE PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; SNCA PROTEIN, HUMAN; SNCB PROTEIN, HUMAN; SYNUCLEIN;

AMINO ACID SEQUENCE; ARTICLE; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN POLYMERIZATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NEUROLOGIC DISEASE; PROTEIN BINDING; PROTEIN CONFORMATION; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; BETA-SYNUCLEIN; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SYNUCLEINS;

EID: 0035951869     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008919200     Document Type: Article

References (36)

1. Baba, M., Nakajo, S., Tu, P., Tomita, T., Nakaya, K., Lee, V. M.-Y., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
2. Wakabayashi, K., Matsumoto, K., Takayama, K., Yoshimoto, M., and Takahashi, H. (1997) Neurosci. Lett. 239, 45-48
3. Takeda, A., Mallory, M., Sundsumo, M., Honer, W., Hansen, L., and Masliah, E. (1998) Am. J. Pathol. 152, 367-372
4. Arima, K., Uéda, K., Sunohara, N., Hirai, S., Izumiyama, Y., Tonozuka-Uehara, H., and Kawai, M. (1998) Brain Res. 808, 93-100
5. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6469-6473
6. Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., and Kawai, M. (1998) Acta Neuropathol. (Berl.) 96, 439-444
7. Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
8. Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Neurosci. Lett. 251, 205-208
9. Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leigth, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., and Lee, V. M.-Y. (1998) Ann. Neurol. 44, 415-422
10. Wakabayashi, K., Hayashi, S., Kakita, A., Yamada, M., Toyoshima, Y., Yoshimoto, M., and Takahashi H. (1998) Acta Neuropathol. (Berl.) 96, 445-452
11. Wakabayashi, K., Yoshimoto, M., Fukushima, H., Koide, R., Horikawa, Y., Morita, T., and Takahashi, H. (1999) Neuropathol. Appl. Neurobiol. 25, 363-368
12. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M.-Y. (1999) J. Biol. Chem. 274, 7619-7622
13. Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Nat. Med. 11, 1318-1320
14. El-Agnaf, O. M. A., Jakes, R., Curran, M. D., and Wallace, A. (1998) FEBS Lett. 440, 67-70
15. Hashimoto, M., Hsu, L. J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M., and Masliah, E. (1998) Brain Res. 799, 301-306
16. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J.-C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-9846
17. Surguchov, A., Surgucheva, I., Solessio, E., and Baehr, W. (1999) Mol. Cell. Neurosci. 13, 95-103
18. Clayton, D. F., and George, J. M. (1998) Trends Neurosci. 21, 249-254
19. Jakes, R., Spillantini, M. G., and Goedert, M. (1994) FEBS Lett. 345, 27-32
20. Shibayama-Imazu, T., Okahashi, I., Omata, K., Nakajo, S., Ochiai, H., Nakai, Y., Hama, T., Nakamura, Y., and Nakaya, K. (1993) Brain Res. 622, 17-25
21. George, J. M., Jin, H., Woods, W. S., and Clayton, D. F. (1995) Neuron 15, 361-372
22. Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., and Saitoh, T. (1995) Neuron 14, 467-475
23. Buchman, V. L., Hunter, H. J. A., Pinön, L. G. P., Thompson, J., Privalova, E. M., Ninkina, N. N., and Davies, A. M. (1998) J. Neurosci. 18, 9335-9341
24. Lippa, C. F., Schmidt, M. L., Lee, V.-M.-Y., and Trojanowski, J. Q. (1999) Ann. Neurol. 45, 353-357
25. Laemmli, U. K. (1970) Nature 227, 680-685
26. Giasson, B. I., Jakes, R., Goedert, M., Duda, J. E., Leight, S., Trojanowski, J. Q., and Lee, V. M.-Y. (2000) J. Neurosci. Res. 274, 528-533
27. Jakes, R., Crowther, R. A., Lee, V. M.-Y., Trojanowski, J. Q., Iwatsubo, T., and Goedert, M. (1999) Neurosci. Lett. 269, 13-16
28. Biere, A. L., Wood, S. J., Wypych, J., Steavenson, S., Jiang, Y., Anafi, D., Jacobsen, F. W., Jarosinski, M. A., Wu, G. M., Louis, J.-C., Martin, F., Narhi, L. O., and Citron, M. J. Biol. Chem. 275, 34574-34579
29. Serpell, L. C., Berriman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
30. Uéda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A. C., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11282-11286
31. Masliah, E., Iwai, A., Mallory, M., Uéda, K., and Saitoh, T. (1996) Am. J. Pathol. 148, 201-210
32. Culvenor, J. G., McLean, C. A., Cutt, S., Campbell, B. C. V., Maher, F., Hartmann, T., Beyreuther, K., Masters, C. L., and Li, Q.-X. (1999) Am. J. Pathol. 155, 1173-1181
33. Bayer, T. A., Jakala, P., Hartmann, T., Havas, L., McLean, C., Culvenor, J. G., Li, Q. X., Masters, C. L., Falkai, P., and Beyreuther, K. (1999) Neurosci. Lett. 266, 213-216
34. El-Agnaf, O. M. A., Jakes, R., Curran, M. D., Middleton, D., Ingenito, R., Bianchi, E., Pessi, A., Neill, D., and Wallace, A. (1998) FEBS Lett. 440, 71-75
35. Galvin, J. E., Uryu, K., Lee, V. M.-Y., and Trojanowski, J. Q. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 13450-13455
36. Duda, J. E., Lee, V. M.-Y., and Trojanowski, J. Q. (2000) J. Neurosci. Res. 61, 121-127