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Neuroscience Letters

Volumn 320, Issue 3, 2002, Pages 146-150

Human α-Synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine

(2) Junn, Eunsung a Mouradian, M Maral a

a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (United States)

Author keywords

Synuclein; Cell death; Dopamine; Parkinson's disease; Reactive oxygen species

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; MUTANT PROTEIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PARKINSON DISEASE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION;

ALPHA-SYNUCLEIN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOPAMINE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; PARKINSON DISEASE; POINT MUTATION; PROTEIN ISOFORMS; REACTIVE OXYGEN SPECIES; SUBSTANTIA NIGRA; SYNUCLEINS;

EID: 0037040491 PISSN: 03043940 EISSN: None Source Type: Journal
DOI: 10.1016/S0304-3940(02)00016-2 Document Type: Article

Times cited : (225)

References (32)

1
- 0020625894
- Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
- (1983) J. Immunol. , vol.130 , pp. 1910-1917
- Bass, D.A.¹ Parce, J.W.² Dechatelet, L.R.³ Szejda, P.⁴ Seeds, M.C.⁵ Thomas, M.⁶

2
- 0025189864
- Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
- (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1620-1624
- Beckman, J.S.¹ Beckman, T.W.² Chen, J.³ Marshall, P.A.⁴ Freeman, B.A.⁵

3
- 0024585155
- Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
- (1989) J. Neurochem. , vol.52 , pp. 381-389
- Dexter, D.T.¹ Carter, C.J.² Wells, F.R.³ Javoy-Agid, F.⁴ Agid, Y.⁵ Lees, A.⁶ Jenner, P.⁷ Marsden, C.D.⁸

4
- 0032573597
- Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
- (1998) FEBS Lett. , vol.440 , pp. 71-75
- El-Agnaf, O.M.¹ Jakes, R.² Curran, M.D.³ Middleton, D.⁴ Ingenito, R.⁵ Bianchi, E.⁶ Pessi, A.⁷ Neill, D.⁸ Wallace, A.⁹

5
- 0034704752
- A Drosophila model of Parkinson's disease
- (2000) Nature , vol.404 , pp. 394-398
- Feany, M.B.¹ Bender, W.W.²

6
- 0034602442
- Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
- (2000) Science , vol.290 , pp. 985-989
- Giasson, B.I.¹ Duda, J.E.² Murray, I.V.³ Chen, Q.⁴ Souza, J.M.⁵ Hurtig, H.I.⁶ Ischiropoulos, H.⁷ Trojanowski, J.Q.⁸ Lee, V.M.⁹

7
- 0033771793
- Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?
- (2000) Nat. Cell Biol. , vol.2
- Goldberg, M.S.¹ Lansbury Jr., P.T.²

8
- 0033577159
- Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
- (1999) NeuroReport , vol.10 , pp. 717-721
- Hashimoto, M.¹ Hsu, L.J.² Xia, Y.³ Takeda, A.⁴ Sisk, A.⁵ Sundsmo, M.⁶ Masliah, E.⁷

9
- 0032879452
- Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease
- (1999) J. Biol. Chem. , vol.274 , pp. 28849-28852
- Hashimoto, M.¹ Takeda, A.² Hsu, L.J.³ Takenouchi, T.⁴ Masliah, E.⁵

10
- 0033890821
- Alpha-Synuclein promotes mitochondrial deficit and oxidative stress
- (2000) Am. J. Pathol. , vol.157 , pp. 401-410
- Hsu, L.J.¹ Sagara, Y.² Arroyo, A.³ Rockenstein, E.⁴ Sisk, A.⁵ Mallory, M.⁶ Wong, J.⁷ Takenouchi, T.⁸ Hashimoto, M.⁹ Masliah, E.¹⁰

11
- 0031899172
- Oxidative mechanisms in nigral cell death in Parkinson's disease
- (1998) Mov. Disord. , vol.13 , pp. 24-34
- Jenner, P.¹

12
- 0034927814
- Apoptotic signaling in dopamine-induced cell death: The role of oxidative stress, p38 mitogen-activated kinase, cytochrome c and caspases
- (2001) J. Neurochem. , vol.78 , pp. 374-383
- Junn, E.¹ Mouradian, M.M.²

13
- 0034008852
- Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
- (2000) Neuroscience , vol.97 , pp. 279-284
- Kanda, S.¹ Bishop, J.F.² Eglitis, M.A.³ Yang, Y.⁴ Mouradian, M.M.⁵

14
- 0034676997
- MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
- (2000) NeuroReport , vol.11 , pp. 211-213
- Kowall, N.W.¹ Hantraye, P.² Brouillet, E.³ Beal, M.F.⁴ McKee, A.C.⁵ Ferrante, R.J.⁶

15
- 0031990490
- Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
- (1998) Nat. Genet. , vol.18 , pp. 106-108
- Kruger, R.¹ Kuhn, W.² Muller, T.³ Woitalla, D.⁴ Graeber, M.⁵ Kosel, S.⁶ Przuntek, H.⁷ Epplen, J.T.⁸ Schols, L.⁹ Riess, O.¹⁰

16
- 0035066885
- Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
- (2001) Fed. Am. Soc. Exp. Biol. J. , vol.15 , pp. 916-926
- Lee, F.J.¹ Liu, F.² Pristupa, Z.B.³ Niznik, H.B.⁴

17
- 0032488992
- Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
- (1998) J. Biol. Chem. , vol.273 , pp. 3756-3764
- Luo, Y.¹ Umegaki, H.² Wang, X.³ Abe, R.⁴ Roth, G.S.⁵

18
- 0034681471
- Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
- (2000) Science , vol.287 , pp. 1265-1269
- Masliah, E.¹ Rockenstein, E.² Veinbergs, I.³ Mallory, M.⁴ Hashimoto, M.⁵ Takeda, A.⁶ Sagara, Y.⁷ Sisk, A.⁸ Mucke, L.⁹

19
- 0031711713
- Mitochondrial dysfunction in Parkinson's disease
- (1998) Ann. Neurol. , vol.44
- Mizuno, Y.¹ Yoshino, H.² Ikebe, S.³ Hattori, N.⁴ Kobayashi, T.⁵ Shimoda-Matsubayashi, S.⁶ Matsumine, H.⁷ Kondo, T.⁸

20
- 0025242960
- Oxidation reactions in Parkinson's disease
- (1990) Neurology , vol.40 , Issue.SUPPL. , pp. 32-39
- Olanow, C.W.¹

21
- 0033565874
- Alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
- (1999) J. Neurosci. , vol.19 , pp. 5782-5791
- Ostrerova, N.¹ Petrucelli, L.² Farrer, M.³ Mehta, N.⁴ Choi, P.⁵ Hardy, J.⁶ Wolozin, B.⁷

22
- 0034663039
- The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity
- (2000) J. Neurosci. , vol.20 , pp. 6048-6054
- Ostrerova-Golts, N.¹ Petrucelli, L.² Hardy, J.³ Lee, J.M.⁴ Farer, M.⁵ Wolozin, B.⁶

23
- 10544234193
- Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
- (1996) Science , vol.274 , pp. 1197-1199
- Polymeropoulos, M.H.¹ Higgins, J.J.² Golbe, L.I.³ Johnson, W.G.⁴ Ide, S.E.⁵ Di Iorio, G.⁶ Sanges, G.⁷ Stenroos, E.S.⁸ Pho, L.T.⁹ Schaffer, A.A.¹⁰ Lazzarini, A.M.¹¹ Nussbaum, R.L.¹² Duvoisin, R.C.¹³

24
- 0030744876
- Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
- (1997) Science , vol.276 , pp. 2045-2047
- Polymeropoulos, M.H.¹ Lavedan, C.² Leroy, E.³ Ide, S.E.⁴ Dehejia, A.⁵ Dutra, A.⁶ Pike, B.⁷ Root, H.⁸ Rubenstein, J.⁹ Boyer, R.¹⁰ Stenroos, E.S.¹¹ Chandrasekharappa, S.¹² Athanassiadou, A.¹³ Papapetropoulos, T.¹⁴ Johnson, W.G.¹⁵ Lazzarini, A.M.¹⁶ Duvoisin, R.C.¹⁷ Di Iorio, G.¹⁸ Golbe, L.I.¹⁹ Nussbaum, R.L.²⁰ more..

25
- 0024557734
- Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
- (1989) J. Neurochem. , vol.52 , pp. 515-520
- Riederer, P.¹ Sofic, E.² Rausch, W.D.³ Schmidt, B.⁴ Reynolds, G.P.⁵ Jellinger, K.⁶ Youdim, M.B.⁷

26
- 0025254401
- Mitochondrial complex I deficiency in Parkinson's disease
- (1990) J. Neurochem. , vol.54 , pp. 823-827
- Schapira, A.H.¹ Cooper, J.M.² Dexter, D.³ Clark, J.B.⁴ Jenner, P.⁵ Marsden, C.D.⁶

27
- 0026644192
- Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease
- (1992) Neurosci. Lett. , vol.142 , pp. 128-130
- Sofic, E.¹ Lange, K.W.² Jellinger, K.³ Riederer, P.⁴

28
- 0030882856
- Alpha-synuclein in Lewy bodies
- (1997) Nature , vol.388 , pp. 839-840
- Spillantini, M.G.¹ Schmidt, M.L.² Lee, V.M.³ Trojanowski, J.Q.⁴ Jakes, R.⁵ Goedert, M.⁶

29
- 0034326816
- Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity
- (2000) Hum. Mol. Genet. , vol.9 , pp. 2683-2689
- Tabrizi, S.J.¹ Orth, M.² Wilkinson, J.M.³ Taanman, J.W.⁴ Warner, T.T.⁵ Cooper, J.M.⁶ Schapira, A.H.⁷

30
- 0035870881
- Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
- (2001) Hum. Mol. Genet. , vol.10 , pp. 919-926
- Tanaka, Y.¹ Engelender, S.² Igarashi, S.³ Rao, R.K.⁴ Wanner, T.⁵ Tanzi, R.E.⁶ Sawa, A.⁷ Dawson, V.L.⁸ Dawson, T.M.⁹ Ross, C.A.¹⁰

31
- 0032493381
- Lower intracellular hydrogen peroxide levels in cells overexpressing CuZn-superoxide dismutase
- (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7872-7875
- Teixeira, H.D.¹ Schumacher, R.I.² Meneghini, R.³

32
- 0035873812
- Alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro
- (2001) Free. Radic. Biol. Med. , vol.30 , pp. 1163-1170
- Turnbull, S.¹ Tabner, B.J.² El-Agnaf, O.M.³ Moore, S.⁴ Davies, Y.⁵ Allsop, D.⁶

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