Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

Journal of Neurochemistry

Volumn 81, Issue 2, 2002, Pages 301-306

  McNaught, Kevin St P ^a,b   Mytilin, Catherine ^a   JnoBaptiste, Ruth ^a   Yabut, Jocelyn ^a   Shashidharan, P ^a   Jenner, Peter ^b   Olanow, C Warren ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

synuclein; 26 20S proteasome; Lewy body inclusion; Parkinson's disease; Ubiquitin C terminal hydrolase L1 and parkin

Indexed keywords

ALPHA SYNUCLEIN; HYDROLASE; LACTACYSTIN; PARKIN; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL DEATH; CELL DEGENERATION; CELL FUNCTION; CELL INCLUSION; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; FETUS; GENE MUTATION; IMMUNOREACTIVITY; LEWY BODY; MESENCEPHALON; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ACETYLCYSTEINE; ALDEHYDES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INCLUSION BODIES; MESENCEPHALON; MULTIENZYME COMPLEXES; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; UBIQUITIN;

ANIMALIA;

EID: 0036316947     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00821.x     Document Type: Article

References (37)

1. A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
2. Degradation of α-synuclein by proteasome
3. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis
4. EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture
5. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
6. Degradation of oxidized proteins by the 20S proteasome
7. Lactacystin, proteasome function, and cell fate
8. Neuropathology of Parkinson's disease
9. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
10. Alpha-synuclein and neurodegenerative diseases
11. Protein nitration in Parkinson's disease
12. Neuronal vulnerability in Parkinson's disease
13. Understanding cell death in Parkinson's disease
14. Effect of the overexpression of wild-type or mutant α-synuclein on cell susceptibility to insult
15. The ubiquitin pathway in Parkinson's disease
16. Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation
17. Altered glial function causes neuronal death and increases neuronal susceptibility to 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced toxicity in astrocytic/ventral mesencephalic co-cultures
18. Proteasomal function is impaired in substantia nigra in Parkinson's disease
19. Failure of the ubiquitin-proteasome system in Parkinson's disease
20. Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease
21. Kinetic studies on the inhibition of isopeptidase T by ubiquitin aldehyde
22. α-synuclein is present in Lewy bodies in sporadic Parkinson's disease
23. Neuronal-enriched cultures from embryonic rat ventral mesencephalon for pharmacological studies of dopamine neurons
24. Pathology and biology of the Lewy body
25. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
26. Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells
27. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
28. Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation
29. Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
30. Immunohistochemical and subcellular localization of Parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients
31. Ubiquitination of a new form of (α)-synuclein by Parkin from human brain: Implications for Parkinson's disease
32. α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
33. Clinical and pathological features of a Parkinsorian syndrome in a family with an Ala53Thr α-synuclein mutation
34. Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
35. Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
36. α-synuclein metabolism and aggregation is linged to ubiqutin-independent degradation by the proteasome
37. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease