Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain

Journal of Neuroscience

Volumn 20, Issue 17, 2000, Pages 6365-6373

  Kahle, Philipp J ^a   Neumann, Manuela ^b   Ozmen, Laurence ^c   Müller, Veronika ^a   Jacobsen, Helmut ^c   Schindzielorz, Alice ^a   Okochi, Masayasu ^a   Leimer, Uwe ^a   Van Der Putten, Herman ^d   Probst, Alphonse ^e   Kremmer, Elisabeth ^f   Kretzschmar, Hans A ^b   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Brain; Lewy body; Parkinson's disease; Synapse; Synaptophysin; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FAMILIAL DISEASE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LEWY BODY; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSGENIC MOUSE;

EID: 0034280435     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-17-06365.2000     Document Type: Article

References (56)

1. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
2. Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein
3. Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
4. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
5. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
6. Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited: NAC and α-synuclein are not associated with Aβ amyloid
7. Stabilization of α-synuclein secondary structure upon binding to synthetic membranes
8. Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
9. A Drosophila model of Parkinson's disease
10. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
11. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
12. Genetic classification of primary neurodegenerative disease
13. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation
14. Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system
15. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
16. Identification of two distinct synucleins from human brain
17. Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein
18. Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins
19. Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
20. α-Synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
21. Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury
22. Differential regulation of a Thy-1 gene in transgenic mice
23. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
24. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
25. Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease
26. The synuclein family
27. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
28. Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
29. Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation
30. The rat brain synucleins; family of proteins transiently associated with neuronal membrane
31. Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
32. Membrane association and protein conformation of α-synuclein in intact neurons
33. Expression in brain of amyloid precursor protein mutated in the α-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice
34. A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation
35. Both familial Parkinson's disease mutations accelerate α-synuclein aggregation
36. Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
37. α-Synuclein shares physical and functional homology with 14-3-3 proteins
38. Mutation in the α-synuclein gene identified in families with Parkinson's disease
39. Double immunolabeling of neuropeptides in the human hypothalamus as analyzed by confocal laser scanning fluorescence microscopy
40. Translating cell biology into therapeutic advances in Alzheimer's disease
41. Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14)
42. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
43. α-Synuclein in Lewy bodies
44. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
45. Synoretin - A new protein belonging to the synuclein family
46. Abnormal distribution of the non-Aβ component of Alzheimer's disease amyloid precursor/α-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment
47. Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders
48. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
49. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
50. Tissue-specific control elements of the Thy-1 gene
51. α-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
52. Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
53. Widespread occurrence of α-synuclein/NACP-immunoreactive neuronal inclusions in juvenile and adult-onset Hallervorden-Spatz disease with Lewy bodies
54. Identification and localization of synaptophysin, an integral membrane glycoprotein of M(r) 38,000 characteristic of presynaptic vesicles
55. Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons