NACP, a presynaptic protein, immunoreactivity in lewy bodies in Parkinson's disease

Neuroscience Letters

Volumn 239, Issue 1, 1997, Pages 45-48

  Wakabayashi, Koichi ^a   Matsumoto, Kayo ^b   Takayama, Kiyoshi ^b   Yoshimoto, Makoto ^b   Takahashi, Hitoshi ^c  

^a NIIGATA UNIVERSITY   (Japan)

^b Medicinal Research Laboratories   (Japan)

^c Niigata University   (Japan)

Author keywords

Immunohistochemistry; Lewy body; NACP; Parkinson's disease; Substantia nigra; Synapse; Synuclein

Indexed keywords

AMYLOID PROTEIN; PRESYNAPTIC PROTEIN; PROTEIN ANTIBODY; PROTEIN PRECURSOR; SYNUCLEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LEWY BODY; NERVE DEGENERATION; NEUROPIL; PARKINSON DISEASE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN METABOLISM; SUBSTANTIA NIGRA; SYNAPSE;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; AMYLOID; CASE-CONTROL STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MIDDLE AGED; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURITES; PARKINSON DISEASE; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SYNUCLEINS;

EID: 0031566042     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00891-4     Document Type: Article

References (13)

1. Bancher C., Lassmann H., Budka H., Jellinger K., Grundke-Iqbal I., Iqbal K., Wiche G., Seitelberger F., Wisniewski H.M. An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J. Neuropathol. Exp. Neurol. 48:1989;81-93.
2. Gai W.P., Blessing W.W., Blumbergs P.C. Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease. Brain. 118:1995;1447-1459.
3. Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A.R., Kittel A., Saitoh T. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:1995;467-475.
4. Jakes R., Spillantini M.G., Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345:1994;27-32.
5. Kuzuhara S., Mori H., Izumiyama N., Yoshimura M., Ihara Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol. 75:1988;345-353.
6. Masliah E., Iwai A., Mallory M., Uéda K., Saitoh T. Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148:1996;201-210.
7. Ohama E., Ikuta F. Parkinson's disease: distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol. 34:1976;311-319.
8. Pollanen M.S., Dickson D.W., Bergeron C. Pathology and biology of the Lewy body. J. Neuropathol. Exp. Neurol. 52:1993;183-191.
9. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
10. Spillantini M.G., Schmidt M.L., Lee V.M.-Y., Trojanowski J.Q., Jakes R., Goedert M. α-Synuclein in Lewy bodies. Nature. 388:1997;839-840.
11. Takahashi H., Iwanaga K., Egawa S., Ikuta F. Ultrastructural relationship between Lewy bodies and pale bodies studied in locus ceruleus neurons of a non-parkinsonian patient. Neuropathology. 14:1994;73-80.
12. Uéda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A.C., Kondo J., Ihara Y., Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;11282-11286.
13. Yoshimoto M., Iwai A., Kang D., Otero D.A.C., Xia Y., Saitoh T. NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ and stimulates Aβ aggregation. Proc. Natl. Acad. Sci. USA. 92:1995;9141-9145.