Antibodies to α-synuclein detect lewy bodies in many down's syndrome brains with alzheimer's disease

Annals of Neurology

Volumn 45, Issue 3, 1999, Pages 353-357

  Lippa, Carol F ^a   Schmidt, M Luise ^b   Lee, Virginia M Y ^b   Trojanowski, John Q ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

ADULT; AGED; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; MALE; NEURITE; NEWBORN; PRIORITY JOURNAL;

AGED; ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; ANTIBODIES; BETA-SYNUCLEIN; BRAIN; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; GAMMA-SYNUCLEIN; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LEWY BODIES; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; SYNUCLEINS;

EID: 0032990543     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199903)45:3<353::AID-ANA11>3.0.CO;2-4     Document Type: Article

References (24)

1. Kosaka K. Diffuse Lewy body disease in Japan. J Neurol 1990; 237:197-204
2. Dickson DW, Ruan D, Crystal H, et al. Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neuntes specific to DLBD. Neurology 1991;41:1402-1409
3. Perry RH, Irving D, Blessed G, et al. Senile dementia of Lewy body type. A clinically and neuropathologically distinct type of Lewy body dementia in the elderly. J Neurol Sci 1990;95:119-139
4. Lennox G, Lowe R, Morrell R, et al. Anti-ubiquitin immunochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease. J Neurol Neurosurg Psychiatry 1989;52:67-71
5. Hansen L, Salmon D, Galasko D, et al. The Lewy body variant of Alzheimer's disease: A clinical and pathological entity. Neurology 1990;40:l-8
6. Lippa CF, Fujiwara H, Mann DMA, et al. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 1998;153:1365-1370
7. Trojanowski JQ, Goedert M, Iwatsubo T, Lee VM-Y. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ 1998 (In press)
8. Irrizary MC, Growdon W, Gomez-Isla T, et al. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity. J Neuropathol Exp Neurol 1998;57:334-337
9. Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047
10. Krüeger R, Kuhn W, Müller T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 1998;18:106-108
11. Baba M, Nakajo S, Tu PH, et al. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998;152:879-884
12. Burger PC, Vogel FS. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am J Pathol 1973;73:457-476
13. Bodhireddy S, Dickson D, Mattice L, Weidenheim KM. A case of Down's syndrome with diffuse Lewy body disease. Neurology 1994;44:159-161
14. Gibb WRG, Mountjoy CQ, Mann DMA, Lees AJ. A pathological study of the association between Lewy body disease and Alzheimer disease. J Neurol Neurosurg Psychiatry 1989;52: 701-708
15. Raghavan R, Khin-Nu C, Brown A, et al. Detection of Lewy bodies in trisomy 21 (Down's syndrome). Can J Neurol Sci 1993;20:48-51
16. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's disease. Consensus recommendations for the postmortem diagnosis of Alzheimer disease. Neurobiol Aging 1997;18(Suppl):S1-S3
17. Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 1995;16:271-284
18. Tu P-H, Galvin JE, Baba M, et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 1998;44: 415-422
19. Schmidt ML, Martin JA, Lee VM-Y, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons in Alzheimer's disease and Lewy body disorders. Acta Neuropathol (Berl) 1996;91:475-481
20. Rezaie P. Cairns NJ, Chadwick A, Lantos PL. Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease. Neurosci Lett 1996;212:111-114
21. Braak H, Braak E, Yilmazer D, et al. Pattern of brain destruction in Parkinson's and Alzheimer's diseases. J Neural Transm Gen Sect 1996;103:455-490
22. Kosaka K. Diffuse Lewy body disease. Rinsho Shinkeigaku 1995;35:1455-1456
23. Tsuchiya K, Kosaka K. Neuropathological study of the amygdala in presenile Alzheimer's disease. J Neurol Sci 1990;100: 165-173
24. Iwatsubo T, Mann DMA, Odaka, et al. Amyloid-β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome. Ann Neurol 1995;37:294-299