Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders

American Journal of Pathology

Volumn 152, Issue 2, 1998, Pages 367-372

  Takeda, Ayako ^a,d   Mallory, Margaret ^a   Sundsmo, Mary ^a   Honer, William ^c   Hansen, Lawrence ^a,b   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID; ANTIBODY; NEUROFILAMENT PROTEIN; SYNAPTOPHYSIN; TAU PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY LABELING; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DEGENERATIVE DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LEWY BODY; MUTATION; PARKINSON DISEASE; PRIORITY JOURNAL;

AGED; AMYLOID; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOLOGIC TECHNIQUES; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PROTEIN PRECURSORS; SYNUCLEINS;

EID: 0031907128     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hof PR, Morrison JH: The cellular basis of cortical disconnection in Alzheimer disease and related dementing conditions. Alzheimer Disease. Edited by RD Terry, R Katzman, KL Bick. New York, Raven Press, 1994, pp 197-230
2. Masliah E, Mallory M, Hansen L, DeTeresa R, Alford M, Terry R: Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci Lett 1994, 174:67-72
3. Sisodia SS, Price DL: Role of the β-amyloid protein in Alzheimer's disease. FASEB J 1995, 9:366-370
4. Masliah E, Terry R: The role of synaptic proteins in the pathogenesis of disorders of the central nervous system. Brain Pathol 1993, 3:77-85
5. Masliah E, Mallory M, Alford M, DeTeresa R, Iwai A, Saitoh T: Molecular mechanisms of synaptic disconnection in Alzheimer's disease. Connections, Cognition and Alzheimer's Disease. Edited by BT Hyman, C Duyckaerts, Y Christen. Berlin, Springer-Verlag, 1997, pp 121-140
6. Masliah E: Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 1995, 10:509-519
7. Polymeropoulos MH, Lavedant C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL: Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047
8. Maroteaux L, Campanelli JT, Scheller RH: Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988, 8:2804-2815
9. Nakajo S, Tsukada K, Omata K, Nakamura Y, Nakaya K: A new brain-specific 14-kd protein is a phosphoprotein: its complete amino acid sequence and evidence for phosphorylation. Eur J Biochem 1993, 217:1057-1063
10. Maroteaux L, Scheller RH: The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Mol Brain Res 1991, 11:335-343
11. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Otero D, Kondo J, Ihara Y, Saitoh T: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease. Proc Natl Acad Sci USA 1993, 90:11282-11286
12. George JM, Jin H, Woods WS, Clayton DF: Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 1995, 15:361-372
13. Jakes R, Spillantini MG, Goedert M: Identification of two distinct synucleins from human brain. FEBS Lett 1994, 345:27-32
14. Iwai A, Masliah E, Yoshimoto M, De Silva R, Ge N, Kittel A, Saitoh T: The precursor protein of non-Aβ component of Alzheimer's disease amyloid (NACP) is a presynaptic protein of the central nervous system. Neuron 1994, 14:467-475
15. Masliah E, Iwai A, Mallory M, Ueda K, Saitoh T: Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am J Pathol 1996, 148:201-210
16. Spillantini MG, Schmidt ML, Lee VM-Y, Trojanowski JQ, Jakes R, Goedert M: α-Synuclein in Lewy bodies. Nature 1997, 388:839-840
17. Wakabayashi K, Hansen LA, Vincent I, Mallory M, Masliah E: Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease. Lewy body disease and progressive supranuclear palsy. Acta Neuropathol 1997, 93:7-12
18. Honer WG, Falkai P, Young C, Wang T, Xie J, Bonner J, Hu L, Boulianne GL, Lu Z, Trimble WS: Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience 1997, 78:99-110
19. Wakabayashi K, Honer WG, Masliah E: Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain Res 1994, 667:24-32
20. Masliah E, Mallory M, Hansen L, Alford M, DeTeresa R, Terry R: An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am J Pathol 1993, 142:871-882
21. Kim J: Evidence that the precursor protein of non-Aβ component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. Mol Cells 1997, 7:78-83
22. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr: NACP, a protein implicated in Alzheimer's disease, and learning, is natively unfolded. Biochemistry 1996, 35:13709-13715
23. Iwai A, Yoshimoto M, Masliah E, Saitoh T: Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 1995, 34:10139-10145
24. Han H, Weinreb PH, Lansbury PT Jr: The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol 1995, 2:163-169
25. Jensen PH, Hojrup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J, Jakes R: Binding of Aβ to α-and β-synucleins: identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC. Biochem J 1997, 323:539-546
26. Yoshimoto M, Iwai A, Kang D, Otero DAC, Xia Y, Saitoh T: NACP, the precursor protein of non-amyloid β/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ, and stimulates Aβ aggregation. Proc Natl Acad Sci USA 1995, 92:9141-9145
27. Arai H, Lee VM-Y, Hill WD, Greenberg BD, Trojanowski JO: Lewy bodies contain β-amyloid precursor proteins of Alzheimer's disease. Brain Res 1992, 585:386-390
28. Nishimura M, Tomimoto H, Suenaga T, Nakamura S, Namba Y, Ikeda K, Akiguchi I, Kimura J: Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains. Brain Res 1994, 634:339-344
29. Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen S-H: Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 1991, 41:1402-1409
30. Kim H, Gearing M, Mirra SS: Ubiqutin-positive CVA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Neurology 1995, 45:1768-1770
31. Gai WP, Blessing WW, Blumberg PC: Ubiqutin-positive degenerating neurites in the brainstem in Parkinson's disease. Brain 1995, 118: 1447-1459
32. Yasuhara O, Matsuo A, Tooyama I, Kimura H, McGeer EG, McGeer PL: Pick's disease immunohistochemistry: new alteration and Alzheimer's disease comparisons. Acta Neuropathol 1995. 89:322-330
33. Iwai A, Masliah E, Sundsmo MP, DeTeresa R, Mallory M, Salmon DP, Saitoh T: The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease. Brain Res 1996, 720:230-234
34. Irizarry MC, Kim TW, McNamara M, Tanzi RE, George JM, Clayton DF, Hyman BT: Characterization of the precursor protein of the non-A β component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol 1996, 55:889-895