A kindred with Parkinson's disease not showing genetic linkage to established loci

Neurology

Volumn 54, Issue 2, 2000, Pages 504-507

  Gwinn Hardy, K A ^a   Crook, R ^a   Lincoln, S ^a   Adler, C H ^b   Caviness, J N ^b   Hardy, J ^a   Farrer, M ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Familial PD; Linkage exclusion; Postural tremor

Indexed keywords

ALPHA SYNUCLEIN;

ARTICLE; CHROMOSOME 2P; CHROMOSOME 4P; FAMILY STUDY; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0034711720     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.54.2.504     Document Type: Article

References (10)

1. Tanner CM, Goldman SM. Epidemiology of Parkinson's disease. Neurol Clin 1996;14:317-335.
2. Farrer M, Gwinn-Hardy K, Hutton M, Hardy J. The genetics of disorders with synuclein pathology and parkinsonism. Hum Mol Genet 1999;8:1901-1905.
3. Gasser T, Müller-Myhsok B, Wszolek ZK, et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat Genet 1998;18:262-265.
4. Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature 1998;395:451-452.
5. Farrer M, Gwinn-Hardy K, Muenter M, et al. A chromosome 4phaplotype segregating with Parkinson's disease and postural tremor. Hum Mol Genet 1999;8:81-85.
6. Polymeropoulos MH, Lavedan C, Leroy E, et al Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2048.
7. Matsumine H, Saito M, Shimoda-Matsubayashi S, et al. Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. Am J Hum Genet 1997;60:588-596.
8. Foster NL, Wilhelmsen K, Sima AAF, et al. Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus. Ann Neurol 1997;42:85-94.
9. Ott J. Analysis of human genetic linkage. 3rd ed. Baltimore: John Hopkins University Press, 1999.
10. O'Connell JR, Weeks DE. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recording and fuzzy inheritance. Nat Genet 1998;11:402-408.