Oxidative dimer formation is the critical rate-limiting step for parkinson's disease α-synuclein fibrillogenesis

Biochemistry

Volumn 42, Issue 3, 2003, Pages 829-837

  Krishnan, Sampathkumar ^a   Chi, Eva Y ^b   Wood, Stephen J ^c   Kendrick, Brent S ^c   Li, Cynthia ^c   Garzon Rodriguez, William ^a   Wypych, Jette ^c   Randolph, Theodore W ^b   Narhi, Linda O ^c   Biere, Anja Leona ^c   Citron, Martin ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b University of Colorado at Boulder   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERIZATION; DISEASE CONTROL; OXIDATION; PROTEINS;

FIBRILLOGENESIS;

BIOCHEMISTRY;

ALPHA SYNUCLEIN; DIMER;

ARTICLE; CROSS LINKING; DIMERIZATION; FIBER; NONHUMAN; OSMOSIS; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DIMERIZATION; HUMANS; HYDROGEN-ION CONCENTRATION; LIGHT; NERVE TISSUE PROTEINS; OSMOLAR CONCENTRATION; OSMOTIC PRESSURE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN ISOFORMS; SCATTERING, RADIATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SYNUCLEINS; TEMPERATURE; TYROSINE;

EID: 0346460948     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026528t     Document Type: Article

References (60)

1. Galvin, J. E., Lee, V. M.-Y., and Trojanowski, J. Q. (2001) Arch. Neurol. 58, 186-190.
2. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047.
3. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108.
4. Feany, M. B., and Bender, W. W. (2000) Nature 404, 394-398.
5. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269.
6. Van der Putten, H., Wiederhold, K.-H., Probst, A., Barbieri, S., Mistl, C., Danner, S., Kauffmann, S., Hofele, K., Spooren, W. P. J. M., Ruegg, M. A., Lin, S., Caroni, P., Sommer, B., Tolnay, M., and Bilbe, G. (2000) J. Neurosci. 20, 6021-6029.
7. Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Odoy, S., Okamoto, N., Jacobsen, H., Iwatsubo, T., Trojanowski, J. Q., Takahashi, H., Wakabayashi, K., Bogdanovic, N., Riederer, P., Kretzschmar, H. A., and Haass, C. (2001) Am. J. Pathol. 159, 2215-2225.
8. Beal, M. F. (1995) Ann. Neurol. 38, 357-366.
9. Butterfield, D. A., and Kanski, J. (2001) Mech. Ageing Dev. 122, 945-962.
10. Paxinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M.-Y., and Ischiropoulos, H. (2001) J. Neurosci. 21, 8053-8061.
11. Giasson, B. I., Duda, J. E., Murray, I. V., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M.-Y. (2000) Science 290, 985-989.
12. Duda, J. E., Giasson, B. I., Chen, Q., Gur, T. L., Hurtig, H. I., Stem, M. B., Gollomp, S. M., Ischiropoulos, H., Lee, V. M.-Y., and Trojanowski, J. Q. (2000) Am. J. Pathol. 157, 1439-1445.
13. Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., and Freed, C. R. (2000) Brain Res. 866, 33-43.
14. Ko, L., Mehta, N. D., Farrer, M., Easson, C., Hussey, J., Yen, S., Hardy, J., and Yen, S. H. (2000) J. Neurochem. 75, 2546-2554.
15. Ostrerova-Golts, N., Petrucelli, L., Hardy, J., Lee, J. M., Farer, M., and Wolozin, B. (2000) J. Neurosci. 20, 6048-6054.
16. Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M.-Y. (1999) J. Biol. Chem. 274, 7619-7622.
17. Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (1998) Nat. Med. 4, 1318-1320.
18. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-9846.
19. Hashimoto, M., Hsu, L. J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., and Masliah, E. (1999) Neuroreport 10, 717-721.
20. Hashimoto, M., Takeda, A., Hsu, L. J., Takenouchi, T., and Masliah, E. (1999) J. Biol. Chem. 274, 28849-28852.
21. Souza, J. M., Giasson, B. I., Chen, Q., Lee, V. M.-Y., and Ischiropoulos, H. (2000) J. Biol. Chem. 275, 18344-18349.
22. Wood, S. J., Wypych, J., Steavenson, S., Louis, J. C., Citron, M., and Biere, A. L. (1999) J. Biol. Chem. 274, 19509-19512.
23. Conway, K. A., Lee, S.-J., Rochet, J.-C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 571-576.
24. Kim, Y. S., Cape, S. P., Chi, E., Raffen, R., Wilkins-Stevens, P., Stevens, F. J., Manning, M. C., Randolph, T. W., Solomon, A., and Carpenter, J. F. (2001) J. Biol. Chem. 276, 1626-1633.
25. Hovorka, S. W., and Schöneich, C. (2001) J. Pharm. Sci. 90, 58-69.
26. Kim, Y., Wall, J. S., Meyer, J., Murphy, C., Randolph, T. W., Manning, M. C., Solomon, A., and Carpenter, J. F. (2000) J. Biol. Chem. 275, 1570-1574.
27. Beckman, J. S., and Koppenol, W. H. (1996) Am. J. Physiol. 217, C1424-C1437.
28. Wen, J., Arakawa, T., and Philo, J. S. (1996) Anal. Biochem. 240, 155-166.
29. Amado, R., Aeschbach, R., and Neukom, H. (1984) Methods Enzymol. 107, 377-388.
30. Krishnan, S., Chi, E. Y., Webb, J. N., Chang, B. S., Shan, D., Goldenberg, M., Manning, M. C., Randolph, T. W., and Carpenter, J. F. (2002) Biochemistry 41, 6422-6431.
31. Kendrick, B. S., Kerwin, B. A., Chang, B. S., and Philo, J. S. (2001) Anal. Biochem. 299, 136-146.
32. George, A., and Wilson, W. W. (1994) Acta Crystallogr. D50, 361-365.
33. Conway, K. A., Harper, J. D., and Lansbury, P. J., Jr. (2000) Biochemistry 39, 2552-2563.
34. Bussell, R., Jr., and Eliezer, D. (2001) J. Biol. Chem. 276, 45996-46003.
35. Wilkins. D. K., Grimshaw, S. B., Receveur, V., Dobson, C. M., Jones, J. A., and Smith, L. J. (1999) Biochemistry 38, 16424-16431.
36. Ackland, C. E., Berndt, W. G., Frezza, J. E., Landgraf, B. E., Pritchard, K. W., and Ciardelli, T. L. (1991) J. Chromatogr. 540, 187-198.
37. Mach, H., and Middaugh, C. R. (1994) Anal. Biochem. 222, 323-331.
38. Servillo, L., Colonna, G., Balestrieri, C., Ragone, R., and Irace, G. (1982) Anal. Biochem. 126, 251-257.
39. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) J. Biol. Chem. 273, 9443-9449.
40. George, A., Chiang, Y., Guo, B., Arabshahi, A., Cai, Z., and Wilson, W. W. (1997) Methods Enzymol. 276, 100-110.
41. Guo, B., Kao, S., McDonald, H., Asanov, A., Combs, L. L., and Wilson, W. W. (1999) J. Cryst. Growth 196, 424-433.
42. Haas, C., Drenth, J., and Wilson, W. W. (1999) J. Phys. Chem. B 103, 2808-2811.
43. Pjura, P. E., Lenhoff, A. M., Leonard, S. A., and Gittis, A. G. (2000) J. Mol. Biol. 300, 235-239.
44. Chang, R. C., Asthagiri, D., and Lenhoff, A. M. (2000) Proteins: Struct., Funct., Genet. 41, 123-132.
45. Neal, B. L., Asthagiri, D., and Lenhoff, A. (1998) Biophys. J. 75, 2469-2477.
46. Jo, E., McLaurin, J., Yip, C. M., George-Hyslop, P. S., and Fraser, P. E. (2000) J. Biol. Chem. 275, 34328-34334.
47. Eliezer, D., Kutluay, E., Robert Bussell, J., and Browne, G. (2001) J. Mol. Biol. 307, 1061-1073.
48. McLean, P. J., Kawamata, H., Ribich, S., and Hyman, B. T. (2000) J. Biol. Chem. 275, 8812-8816.
49. Narayanan, V., and Scarlata, S. (2001) Biochemistry 40, 9927-9934.
50. Betts, S., HassePettingell, C., and King, J. (1997) Adv. Protein Chem. 50, 243-264.
51. Fink, A. L. (1998) Folding Des. 3, R9-R23.
52. Kendrick, B. S., Carpenter, J. F., Cleland, J. L., and Randolph, T. W. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 14142-14146.
53. Webb, J. N., Webb, S. D., Cleland, J. L., Carpenter, J. F., and Randolph, T. W. (2001) Proc. Natl. Acad. Sci, U.S.A. 8, 7259-7264.
54. Wetzel, R. (1994) Trends Biotechnol. 12, 193-198.
55. Rosenbaum, D. F., Kulkarni, A., Ramakrishnan, S., and Zukoski, C. F. (1999) J. Chem. Phys. 111, 9882-9890.
56. Farnum, M., and Zukoski, C. (1999) Biophys. J. 76, 2716-2726.
57. Rosenbaum, D., Zamora, P. C., and Zukoski, C. F. (1996) Phys. Rev. Lett. 76, 150-153.
58. Haas, C., and Drenth, J. (1999) J. Cryst. Growth 196, 388-394.
59. Curtis, R. A., Blanch, H. W., and Prausnitz, J. M. (2001) J. Phys. Chem. B 105, 2445-2452.
60. Kulkarni, A. M., and Zukoski, C. F. (2002) Langmuir 18, 3090-3099.