Ubiquitin and the synapse

Nature Reviews Neuroscience

Volumn 3, Issue 11, 2002, Pages 854-861

  Hegde, Ashok N ^a   DiAntonio, Aaron ^b  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; MULTIENZYME COMPLEX; PROTEASOME; UBIQUITIN;

ANIMAL; CELL DIFFERENTIATION; CELL MEMBRANE; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; NERVE CELL PLASTICITY; NERVOUS SYSTEM; PHYSIOLOGY; PROTEIN TRANSPORT; REVIEW; SYNAPTIC TRANSMISSION; SYNAPTOSOME;

ANIMALS; CELL DIFFERENTIATION; CELL MEMBRANE; CYSTEINE ENDOPEPTIDASES; HUMANS; MULTIENZYME COMPLEXES; NERVOUS SYSTEM; NEURONAL PLASTICITY; PRESYNAPTIC TERMINALS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; SYNAPTIC TRANSMISSION; UBIQUITIN;

EID: 0036832462     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn961     Document Type: Article

References (62)

1. Ciechanover, A., Heller, H., Elias, S., Haas, A. L. & Hershko, A. ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc. Natl Acad. Sci. USA 77, 1365-1368 (1980).
2. Hershko, A., Ciechanover, A., Heller, H., Haas, A. L. & Rose, I. A. Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP- dependent proteolysis. Proc. Natl Acad. Sci. USA 77, 1783-1786 (1980).
3. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425-479 (1998).
4. Tanaka, K. & Chiba, T. The proteasome: a protein-destroying machine. Genes Cells 3, 499-510 (1998).
5. Patrick, G. N., Zhou, P, Kwon, Y T, Howley, P M. & Tsai, L. H. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 273, 24057-24064 (1998).
6. Yamamoto, Y., Hegde, A. N., Chain, D. G. & Schwartz, J. H. Activation and degradation of the transcription factor C/EBP during long-term facilitation in Aplysia. J. Neurochem. 73, 2415-2423 (1999).
7. Musti, A. M., Treier, M. & Bohmann, D. Reduced ubiquitin- dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275, 400-402 (1997).
8. Schwarzschild, M. A., Cole, R. L. & Hyman, S. E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17, 3455-3466 (1997).
9. Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E. & Woodgett, J. R. Phosphorylation of c-jun mediated by MAP kinases. Nature 353, 670-674 (1991).
10. Gieffers, C., Peters, B. H., Kramer, E. R., Dotti, C. G. & Peters, J. M. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc. Natl Acad. Sci. USA 96, 11317-11322 (1999).
11. Lahav-Baratz, S., Sudakin, V, Ruderman, J. V. & Hershko, A. Reversible phosphorylation controls the activity of cyclosome associated cyclin-ubiquitin ligase. Proc. Natl Acad. Sci. USA 92, 9303-9307 (1995).
12. 2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J. 20, 5528-5539 (1999).
13. Hochstrasser, M. Evolution and function of ubiquitin-like protein-conjugation systems. Nature Cell Biol. 2, E153-E157 (2000).
14. Wilkinson, K. D. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin. Cell Dev. Biol. 11, 141-148 (2000).
15. Hadari, T, Warms, J. V, Rose, I. A. & Hershko, A. A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. J. Biol. Chem. 267, 719-727 (1992).
16. DiAntonio, A. et al. Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412, 449-452 (2001).
17. Hegde, A. N. et al. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115-126 (1997).
18. Muralidhar, M. G. & Thomas, J. B. The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes. Neuron 11, 253-266 (1993).
19. Oh, C. et al. bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog. J. Neurosci. 14, 3166-3179 (1994).
20. Hegde, A. N., Goldberg, A. L. & Schwartz, J. H. Regulatory subunits of the cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. Proc. Natl Acad. Sci. USA 90, 7436-7440 (1993).
21. Yu, T. W. & Bargmann, C. I. Dynamic regulation of axon guidance. Nature Neurosci. 4 (Suppl.), 1169-1176 (2001).
22. Zhang, L. I. & Poo, M. M. Electrical activity and development of neural circuits. Nature Neurosci. 4 (Suppl.), 1207-1214 (2001).
23. Doherty, P G. et al. CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade. Mol. Cell. Neurosci. 16, 283-295 (2000).
24. Korey, C. A. & Van Vactor, D. From the growth cone surface to the cytoskeleton: one journey, many paths. J. Neurobiol. 44, 184-193 (2000).
25. Campbell, D. S. & Holt, C. E. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32, 1013-1026 (2001).
26. Myat, A. etal. Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the Roundabout receptor. Neuron 35, 447-459 (2002).
27. Kidd, T. et al. Dosage-sensitive and complementary functions of Roundabout and Commissureless control axon crossing of the CNS midline. Neuron 20, 25-33 (1998).
28. Kidd, T. et al. Slit is the midline repellent for the Robo receptor in Drosophila. Cell 96, 785-794 (1999).
29. Wolf, B. et al. Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis. Development 125, 3853-3863 (1998).
30. Huang, Y. et al. Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene. Science 270, 1828-1831 (1995).
31. Wan, H. I. et al. Highwire regulates synaptic growth in Drosophila. Neuron 26, 313-329 (2000).
32. Joazeiro, C. A. & Weissman, A. M. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102, 549-552 (2000).
33. Schaefer, A. M. et ail rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in el eiegans. Neuron 26, 345-356 (2000).
34. Zhen, M. et al. Regulation of presynaptic terminal organization by el eiegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron 26, 331-343 (2000).
35. Guo, Q. et al. Identification of a large Myc-binding protein that contains RCC1-like repeats. Proc. NatlAcad. Sci USA 95, 9172-9177 (1998).
36. Chen, X. et al. A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev. 16, 289-294 (2002).
37. Craig, A. M. Activity and synaptic receptor targeting: the long view. Neuron 21, 459-462 (1998).
38. Terrell, J., Shih, S., Dunn, R. & Hicke, L. A function for monoubiquitination in the internalization of a G-protein coupled receptor. Mol. Cell 1, 193-202 (1998).
39. Hicke, L. Protein regulation by monoubiquitin. Nature Rev. Mol. Cell Biol. 2, 195-201 (2001).
40. Buttner, C. et al. Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. J. Biol. Chem. 276, 42978-42985 (2001).
41. Bedford, F. K. et al. GABAa receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nature Neurosci. 4, 908-916 (2001).
42. Burbea, M. et al. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 35, 107-120 (2002). The Wheeler, T. C. et al. Regulation of synaptophysin degradation by mammalian homologues of Seven in Absentia. J. Biol. Chem. 277, 10273-10282 (2002).
43. Abrams, T. W. Activity-dependent presynaptic facilitation: an associative mechanism in Aplysia. Cell. Mol. Neurobiol. 5, 123-145 (1985).
44. Byrne, J. H. & Kandel, E. R. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16, 425-435 (1996).
45. Chain, D. G. et al. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22, 1-10 (1999).
46. Jiang, Y.-H. et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21, 799-811 (1998).
47. Kishino, T., Lalande, M. & Wagstaff, J. UBE3a/E6-AP mutations cause Angelman syndrome. Nature Genet. 15, 70-73 (1997).
48. Matsuura, T et al. De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nature Genet. 15, 74-77 (1997).
49. Lopez-Salon M. et al. The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Eur. J. Neurosci. 14, 1820-1826 (2001).
50. Abriel, H., Kamynina, E., Horisberger, J. D. & Staub, O. Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4. FEBS Lett. 466, 377-380 (2000).
51. Staub, O. et al. Regulation of stability and function of the epithelial Na+channel (ENaC) by ubiquitination. EMBO J. 16, 6325-6336 (1997).
52. Long, X. & Griffith, L. C. Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster. J. Biol. Chem. 275, 40765-40776 (2000).
53. Mori, S., Heldin, C. H. & Claesson-Welsh, L. Ligand-induced polyubiquitination of the platelet-derived growth factor β-receptor. J. Biol. Chem. 267, 6429-6434 (1992).
54. Chen, H. et al. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 394, 793-797 (1998).
55. Polo, S. et al. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416, 451-455 (2002).
56. Shih, S. C. et al. Epsins and Vps27p/Hrs contain ubiquitin- binding domains that function in receptor endocytosis. Nature Cell Biol. 4, 389-393 (2002).
57. Raiborg C. et al. Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nature Cell Biol. 4, 394-398 (2002).
58. Katzmann, D. J., Babust, M. & Emr, S. D. Ubiquitin- dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106, 145-155 (2001).
59. β-TrCP ubiquitin ligase-mediated processing of NF- κB p105 requires phosphorylation of its C-terminus by IκB kinase. EMBO J. 19, 2580-2591 (2000).
60. Met30-mediated inactivation of the transcription factor Met4. Cell 102, 303-314 (2000).
61. Salghetti, S. E., Caudy, A. A., Chenoweth, J. G. & Tansey, W. P. Regulation of transcriptional activation domain function by ubiquitin. Science 293, 1651-1653 (2001).
62. Conaway, R. C., Brower, C. S. & Conaway, J. W. Emerging roles of ubiquitin in transcription regulation. Science 296, 1254-1258 (2002).