Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes

EMBO Reports

Volumn 3, Issue 6, 2002, Pages 583-588

  Kahle, Philipp J ^a   Neumann, Manuela ^a   Ozmen, Laurence ^a   Müller, Veronika ^a   Jacobsen, Helmut ^a   Spooren, Will ^a   Fuss, Babette ^a   Mallon, Barbara ^a   Macklin, Wendy B ^a   Fujiwara, Hideo ^a   Hasegawa, Masato ^a   Iwatsubo, Takeshi ^a   Kretzschmar, Hans A ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GREEN FLUORESCENT PROTEIN; PROTEOLIPID PROTEIN; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SNCA PROTEIN, MOUSE; SYNUCLEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL INCLUSION; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; GLIA CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICROSCOPY; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REPRODUCIBILITY; SHY DRAGER SYNDROME; SOLUBILITY; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BRAIN; CONFOCAL MICROSCOPY; GENETICS; METABOLISM; PHOSPHORYLATION;

ALPHA-SYNUCLEIN; ANIMALS; BRAIN; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MULTIPLE SYSTEM ATROPHY; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; PHOSPHORYLATION; SOLUBILITY; SYNUCLEINS;

EID: 0036304315     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf109     Document Type: Article

References (25)

1. NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
2. The solubility of α-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
3. Widespread alterations of α-synuclein in multiple system atrophy
4. Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy
5. α-Synuclein is phosphorylated in synucleinopathy lesions
6. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein
7. α-Synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components
8. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
9. Consensus statement on the diagnosis of multiple system atrophy
10. Multiple system atrophy: The putative causative role of environmental toxins
11. Manipulating the Mouse Embryo: A Laboratory Manual
12. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
13. Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain
14. Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
15. The definition of multiple system atrophy: A review of recent developments
16. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development
17. Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
18. Analysis of the expression level of α-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy
19. Synucleins are a novel class of substrates for G protein-coupled receptor kinases
20. α-Synuclein is developmentally expressed in cultured rat brain oligodendrocytes
21. Expression of α-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease
22. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
23. Expression of α-synuclein in a human glioma cell line and its up-regulation by interleukin-1β
24. Starnberg trial on epidemiology of Parkinsonism and hypertension in the elderly. Prevalence of Parkinson's disease and related disorders assessed by a door-to-door survey of inhabitants older than 65 years
25. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein