Dityrosine cross-linking promotes formation of stable α-synuclein polymers: Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

Journal of Biological Chemistry

Volumn 275, Issue 24, 2000, Pages 18344-18349

  Souza, José M ^a,b   Giasson, Benoit I ^a   Chen, Qiping ^a   Lee, Virginia M Y ^a   Ischiropoulos, Harry ^a,c  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CARBON DIOXIDE; HYDROGEN PEROXIDE; MYELOPEROXIDASE; NITRITE; OLIGOMER; PEROXYNITRITE; TYROSINE;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; GLIA CELL; HUMAN; LEWY BODY; MOLECULAR WEIGHT; NITRATION; OXIDATIVE STRESS; PARKINSON DISEASE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CROSS LINKING; SHY DRAGER SYNDROME; THERMOSTABILITY;

ALPHA-SYNUCLEIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NITRATES; OXIDATIVE STRESS; POLYMERS; RECOMBINANT PROTEINS; SYNUCLEINS; TYROSINE;

EID: 0034674652     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M000206200     Document Type: Article

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