Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Nature

Volumn 416, Issue 6880, 2002, Pages 535-539

  Walsh, Dominic M ^a   Klyubin, Igor ^b   Fadeeva, Julia V ^a   Cullen, William K ^b   Anwyl, Roger ^c   Wolfe, Michael S ^a   Rowan, Michael J ^b   Selkoe, Dennis J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Physiology   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DISEASES; MONOMERS; PLASTICITY; PROTEINS;

NEUROTOXIC SPECIES;

OLIGOMERS;

AMYLOID; AMYLOID BETA PROTEIN; INSULINASE; MONOMER; OLIGOMER;

PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN REGION; BRAIN TISSUE; CELL SECRETION; CELLULAR DISTRIBUTION; CEREBROSPINAL FLUID ANALYSIS; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; INSULIN DEGRADATION; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SECRETION; SECRETORY VESICLE; SPECIES IDENTIFICATION; SYNAPTIC TRANSMISSION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; ENDOPEPTIDASES; HIPPOCAMPUS; HUMANS; INSULYSIN; LONG-TERM POTENTIATION; MICROSOMES; PROTEASE INHIBITORS; RATS; RECOMBINANT PROTEINS; SENILE PLAQUES;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0037041426     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/416535a     Document Type: Article

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