Parkinson's disease: One biochemical pathway to fit all genes?

Trends in Molecular Medicine

Volumn 8, Issue 5, 2002, Pages 236-240

  Krüger, Rejko ^a   Eberhardt, Olaf ^a   Riess, Olaf ^a,a   Schulz, Jörg B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; HYDROLASE; PARKIN; PROTEIN; PROTEIN UCH L1; UNCLASSIFIED DRUG;

GENE MUTATION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC RISK; GENOTYPE; HUMAN; LEWY BODY; PARKINSON DISEASE; PHENOTYPE; PROTEIN AGGREGATION; REVIEW;

ALPHA-SYNUCLEIN; ANIMALS; GENOTYPE; HUMANS; LIGASES; MODELS, BIOLOGICAL; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PHENOTYPE; SYNUCLEINS; THIOLESTER HYDROLASES; UBIQUITIN THIOLESTERASE; UBIQUITIN-PROTEIN LIGASES;

EID: 0036247208     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02333-X     Document Type: Review

References (63)

1. Understanding cell death in Parkinson's disease
2. Prospects for new restorative and neuroprotective treatments in Parkinson's disease
3. Dopaminergic function in familial Parkinson's disease: A clinical and 18F-dopa positron emission tomography study
4. The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins
5. Parkinson's disease in twins studied with 18F-dopa and positron emission tomography
6. Familial aggregation of Parkinson's disease in Iceland
7. Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
8. Mutation in the α-synuclein gene identified in families with Parkinson's disease
9. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
10. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
11. Association between early-onset Parkinson's disease and mutations in the Parkin gene
12. The ubiquitin pathway in Parkinson's disease
13. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease
14. A susceptibility locus for Parkinson's disease maps to chromosome 2p13
15. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor
16. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36
17. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36
18. A susceptibility gene for late-onset idiopathic Parkinson's disease successfully mapped
19. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1
20. Genome-wide scan for Parkinson's disease: The GenePD study
21. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
22. Complete genomic screen in Parkinson disease: Evidence for multiple genes
23. α-synuclein gene haplotypes are associated with Parkinson's disease
24. Increased susceptibility to sporadic Parkinson's disease by a certain combined α-synuclein/apolipoprotein E genotype
25. Failure of the ubiquitin-proteasome system in Parkinson's disease
26. The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
27. α-synuclein and the Parkinson's disease-related mutant Ala53Thr-α-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells
28. Degradation of α-synuclein by proteasome
29. α-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
30. Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells
31. Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
32. Effect of the overexpression of wild-type or mutant α-synuclein on cell susceptibility to insult
33. Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
34. Degradation of α-synuclein by proteasome
35. Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
36. Proteasomal function is impaired in substantia nigra in Parkinson's disease
37. α-synuclein in Lewy bodies
38. α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
39. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity
40. α-synuclein in neurodegenerative disorders: Murderer or accomplice?
41. Human and mouse α-synuclein genes: Comparative genomic sequence analysis and identification of a novel gene regulatory element
42. Effect of allelic variation at the NACP-Repl repeat upstream of the a-synuclein gene (SNCA) on transcription in a cell culture luceferase reporter system
43. Lewy bodies and parkinsonism in families with parkin mutations
44. The ubiquitin system for protein degradation
45. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
46. A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population
47. Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients
48. Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease
49. No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease
50. Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymerphism and PD
51. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
52. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
53. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release
54. Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
55. Ubiquitination of a new form of α-synuclein by parkin from human brain: Implications for Parkinson's disease
56. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
57. Kinetic stability of the α-synuclein protofibril by a dopamine-α-synuclein adduct
58. Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
59. Interaction of α-synuclein and synphilin-1: Effect of Parkinson's disease-associated mutations
60. Synphilin-1 is present in Lewy bodies in Parkinson's disease
61. Untangling tau-related dementia
62. Park6-linked parkinsonism occurs in several european families
63. Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: Expanding the phenotype