Golgi fragmentation occurs in the cells with prefibrillar α-synuclein aggregates and precedes the formation of fibrillar inclusion

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 48984-48992

  Gosavi, Nirmal ^a   Lee, He Jin ^a   Lee, Jun Sung ^b   Patel, Smita ^a   Lee, Seung Jae ^a  

^a PARKINSON S INSTITUTE   (United States)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DISEASES; NEUROLOGY; PROTEINS;

GLOGI FRAGMENTATION;

CELLS;

ALPHA SYNUCLEIN; DOPAMINE TRANSPORTER;

ANIMAL CELL; ARTICLE; CELL INCLUSION; CELL KINETICS; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; FIBER; GOLGI COMPLEX; LYSOSOME; MITOCHONDRION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

ALPHA-SYNUCLEIN; ANIMALS; COS CELLS; CYTOPLASM; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GOLGI APPARATUS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; SYNUCLEINS;

ANIMALIA;

EID: 0037073748     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208194200     Document Type: Article

References (43)

1. Hardy, J., and Gwinn-Hardy, K. (1998) Science 282, 1075-1079
2. Trojanowski, J. Q., Goedert, M., Iwatsubo, T., and Lee, V. M.-Y. (1998) Cell Death Differ. 5, 832-837
3. Goedert, M. (2001) Nat. Rev. Neurosci. 2, 492-501
4. Giasson, B. I., Uryu, H., Trojanowski, J. Q., and Lee, V. M.-Y. (1999) J. Biol. Chem. 274, 7619-7622
5. Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Biochemistry 39, 2552-2563
6. Serpell, L. C., Berriman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
7. Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., and Lee, V. M.-Y. (2002) Neuron 34, 521-533
8. Auluck, P. K., Chan, H. Y., Trojanowski, J. Q., Lee, V. M.-Y., and Bonini, N. M. (2002) Science 295, 865-868
9. Conway, K. A., Lee, S.-J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
10. Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Science 294, 1346-1349
11. Lee, H.-J., Shin, S. Y., Choi, C., Lee, Y. H., and Lee, S.-J. (2002) J. Biol. Chem. 277, 5411-5417
12. Lee, S.-J., Liyanage, U., Bickel, P. E., Xia, W., Lansbury, P. T., Jr., and Kosik, K. S. (1998) Nat. Med. 4, 730-734
13. Bouley, D. M., Ghori, N., Mercer, K. L., Falkow, S., and Ramakrishnan L. (2001) Infect. Immun. 69, 7820-7831
14. Melikian, H. E., and Buckley, K. M. (1999) J. Neurosci. 19, 7699-7710
15. Lee, H.-J., Choi, C., and Lee, S. J. (2002) J. Biol. Chem. 277, 671-678
16. Gonatas, N. K., Gonatas, J. O., and Stieber, A. (1995) Histochem. Cell Biol. 109, 591-600
17. Sakurai, A., Okamoto, K., Fujita, Y., Nakazato, Y., Wakabayashi, K., Takahashi, H., and Gonatas, N. K. (2000) Acta Neuropathol. 100, 270-274
18. Sakurai, A., Okamoto, K., Yaguchi, M., Fujita, Y., Mizuno, Y., Nakazato, Y., and Gonatas, N. K. (2002) Acta Neuropathol. 103, 550-554
19. Wakabayashi, K., Hayashi, S., Kakita, A., Yamada, M., Toyoshima, Y., Yoshimoto, M., and Takahashi, H. (1998) Acta Neuropathol. 96, 445-452
20. Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Neurosci. Lett. 251, 205-208
21. Dickson, D. W., Liu, W., Hardy, J., Farrer, M., Mehta, N., Uitti, R., Mark, M., Zimmerman, T., Golbe, L., Sage, J. Sima, A., D'Amato, C., Albin, R., Gilman, S., and Yen, S. H. (1999) Am. J. Pathol. 155, 1241-1251
22. Garcia-Mata, R., Bebok, Z., Sorscher, E. J., and Sztul, E. S. (1999) J. Cell Biol. 146, 1239-1254
23. Garcia-Mata, R., Gao, Y. S., and Sztul, E. (2002) Traffic 3, 388-396
24. Kopito, R. R. (2000) Trends Cell Biol. 10, 524-530
25. Wigley, W. C., Fabunmi, R. P., Lee, M. G., Marino, C. R., Muallem, S., DeMartino, G. N., and Thomas, P. J. (1999) J. Cell Biol. 145, 481-490
26. Ostrerova, N., Petrucelli, L., Farrer, M. Mehta, N., Choi, P., Hardy, J., and Wolozin, B. (1999) J. Neurosci. 19, 5782-5791
27. Zhou, W. Schaack, J., Zawada, W. M., and Freed, C. R. (2002) Brain Res. 926, 42-50
28. Iwata, A., Maruyama, M., Kanazawa, I., and Nukina, N. (2001) J. Biol. Chem. 276, 45320-45329
29. Saha, A. R., Ninkina, N. N., Hanger, D. P., Anderton, B. H., Davies, A. M., and Buchman, V. L. (2000) Eur. J. Neurosci. 12, 3073-3077
30. Mourelatos, Z. Gonatas, N. K., Stieber, A. Gurney, M. E., and Dal Canto, M. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5472-5477
31. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269
32. Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., and Orr, H. T. (1998) Cell 95, 41-53
33. Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M. E. (1998) Cell 95, 55-66
34. Cummings, C. J., Reinstein, F., Sun, Y., Antalffy, B., Jiang, Y., Ciechanover, A., Orr, H. T., Beaudet, A. L., and Zoghbi, H. Y. (1999) Neuron 24, 879-892
35. Faber, P. W., Alter, J. R., MacDonald, M. E., and Hart, A. C. (1999) Proc. Natl. Acad. Sci. U. S. A 96, 179-184
36. Kazemi-Esfarjani, P., and Benzer, S. (2000) Science 287, 1837-1640
37. Johnston, J. A., Dalton, M. J., Gurney, M. E., and Kopito, R. R. (2000) Proc. Natl. Acad Sci. U. S. A. 97, 12571-12576
38. Bence, N. F., Sampat, R. M., and Kopito, R. R. (2001) Science 292, 1552-1555
39. Thyberg, J., and Moskalewski, S. (1999) Exp. Cell Res. 246, 263-279
40. Yang, W., and Storrie, B. (1998) Mol. Biol. Cell 9, 191-207
41. Volles, M. J., Lee, S.-J., Rochet, J. C., Shtilerman, M. D., Ding, T. T., Kessler, J. C., and Lansbury, P. T., Jr. (2001) Biochemistry 40, 7812-7819
42. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M. and Stefani, M. (2002) Nature 416, 507-511
43. Lee, H.-J., and Lee, S.-J. (2002) J. Biol. Chem. 277, 48976-48983