α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP

Journal of Neurochemistry

Volumn 74, Issue 2, 2000, Pages 721-729

  Vila, Miquel ^a   Vukosavic, Slobodanka ^a   Jackson Lewis, Venice ^a   Neystat, Michael ^a   Jakowec, Michael ^a   Przedborski, Serge ^a,b  

^a Columbia University ^*  (United States)

^b PARKINSON S INSTITUTE   (United States)

Author keywords

Dopaminergic neurons; MPTP; Neurodegeneration; Parkinson's disease; Substantia nigra; Synuclein

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE MUTATION; LEWY BODY; MALE; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ALPHA-SYNUCLEIN; ANIMALS; DOPAMINE; DOPAMINE AGENTS; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MPTP POISONING; NERVE TISSUE PROTEINS; NEURONS; PARKINSONIAN DISORDERS; RNA, MESSENGER; SUBSTANTIA NIGRA; SYNUCLEINS; TISSUE DISTRIBUTION; UP-REGULATION;

EID: 0033966487     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.740721.x     Document Type: Article

References (43)

1. Burke R. E. and Kholodilov N. G. (1998) Programmed cell death: does it play a role in Parkinson's disease? Ann. Neurol. 44, S126-S133.
2. Clarke P. G. H. and Oppenheim R. W. (1995) Neuron death in vertebrate development: in vitro methods. Methods Cell Biol. 46, 277-321.
3. Clayton D. F. and George J. M. (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 21, 249-254.
4. Coggeshall R. E. and Lekan H. A. (1996) Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. Comp. Neurol. 364, 6-15.
5. Conway K. A., Harper J. D., and Lansbury P. T. (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nat. Med. 4, 1318-1320.
6. Descarries L., Watkins K. C., Garcia S., Bosler O., and Doucet G. (1996) Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: a quantitative autoradiographic and immunocytochemical analysis. J. Comp. Neurol. 375, 167-186.
7. El-Agnaf O. M., Jakes R., Curran M. D., and Wallace A. (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Lett. 440, 67-70.
8. Engelender S., Juo X., Hoffman B. E., Lee M. K., Sharp A. H., Zhang C., Cooper J. K., Herreng W. J., Troncoso J. C., Price D. L., Lanahan A., Worley P., Dawson V. L., Dawson T. M., and Ross C. A. (1998) Alpha-synuclein interacts in vivo with another protein (synphilin 1). Mov. Disord. 13 (Suppl. 2), 87.
9. Engelender S., Kaminsky Z., Guo X., Sharp A. H., Amaravi R. K., Kleiderlein J. J., Margolis R. L., Troncoso J. C., Lanahan A. A., Worley P. F., Dawson V. L., Dawson T. M., and Ross C. A. (1999) Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22, 110-114.
10. Fahn S. (1988) Parkinsonism, in Cecil's Textbook of Medicine (Wyngaarden J. B. and Smith L. H. Jr., eds), pp. 2143-2147. Saunders, Philadelphia.
11. Forno L. S., Langston J. W., DeLanney L. E., and Irwin I. (1988) An electron microscopic study of MPTP-induced inclusion bodies in an old monkey. Brain Res. 448, 150-157.
12. Franklin K. B. J. and Paxinos G. (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, San Diego.
13. George J. M., Jin H., Woods W. S., and Clayton D. F. (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15, 361-372.
14. Giasson B. I., Uryu K., Trojanowski J. Q., and Lee V. M. (1999) Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem. 274, 7619-7622.
15. Golbe L. I. (1999) Alpha-synuclein and Parkinson's disease. Mov. Disord. 14, 6-9.
16. Hashimoto M., Hsu L. J., Xia Y., Takeda A., Sisk A., Sundsmo M., and Masliah E. (1999) Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport 10, 717-721.
17. + within the monoaminergic systems of the primate brain following MPTP administration: an in vivo autoradiographic study. Neuroscience 40, 133-158.
18. Irizarry M. C., Kim T. W., McNamara M., Tanzi R. E., George J. M., Clayton D. F., and Hyman B. T. (1996) Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J. Neuropathol. Exp. Neurol. 55, 889-895.
19. Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H. A., Kittel A., and Saitoh T. (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467-475.
20. Iwai A., Masliah E., Sundsmo M. P., De Teresa R., Mallory M., Salmon D. P., and Saitoh T. (1996) The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease. Brain Res. 720, 230-234.
21. Jackson-Lewis V., Jakowec M., Burke R. E., and Przedborski S. (1995) Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 4, 257-269.
22. Jenco J. M., Rawlingson A., Daniels B., and Morris A. J. (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by α-and β-synucleins. Biochemistry 37, 4901-4909.
23. 2 are resistant to MPTP neurotoxicity. J. Neurochem. 71, 2634-2637.
24. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Pzuntek H., Epplen J. T., Schols L., and Riess O. (1998) Ala30Pro mla30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 107-108.
25. Lavedan C. (1998) The synuclein family. Genome Res. 8, 871-880.
26. Mandir A. S., Przedborski S., Jackson-Lewis V., Wang Z. Q., Simbulan-Rosenthal M., Smulson M. E., Hoffman B. E., Guastella D. B., Dawson V. L., and Dawson T. M. (1999) Poly (ADP-ribose) polymerase activation mediates MPTP-induced parkinsonism. Proc. Natl. Acad. Sci. USA 96, 5774-5779.
27. Maroteaux L. and Scheller R. H. (1991) The rat brain synucleins: family of proteins transiently associated with neuronal membrane. Mol. Brain Res. 11, 335-343.
28. Masliah E., Iwai A., Mallory M., Ueda K., and Saitoh T. (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol 148, 201-210.
29. Merry D. E. and Korsmeyer S. J. (1997) Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20, 245-267.
30. Narhi L., Wood S. J., Steavenson S., Jiang Y., Wu G. M., Anati D., Kaufman S. A., Martin F., Sitney K., Denis P., Louis J. C., Wypych J., Biere A. L., and Citron M. (1999) Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J. Biol. Chem. 274, 9843-9846.
31. Oo T. F. and Burke R. E. (1997) The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra. Dev. Brain Res. 98, 191-196.
32. Oppenheim R. W. (1991) Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501.
33. Petersen K., Diesen O. E., and Mikkelsen J. D. (1999) Developmental expression of α-synuclein in rat hippocampus and cerebral cortex. Neuroscience 91, 651-659.
34. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., and Nussbaum R. L. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
35. Przedborski S. and Jackson-Lewis V. (1998) Mechanisms of MPTP toxicity. Mov. Disord. 13 (Suppl. 1), 35-38.
36. Przedborski S., Jackson-Lewis V., Yokoyama R., Shibata T., Dawson V. L., and Dawson T. M. (1996) Role of neuronal nitric oxide in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. USA 93, 4565-4571.
37. Spillantini M. G., Schmidt M. L., Lee V. M. Y., Trojanowski J. Q., Roos J., and Goedert M. (1997) α-Synuclein in Lewy bodies. Nature 388, 839-840.
38. Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M., and Goedert M. (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95, 6469-6473.
39. Suzuki T., Fujikura K., Higashiyama T., and Takata K. (1997) DNA staining for fluorescence and laser confocal microscopy. J. Histochem. Cytochem. 45, 49-53.
40. Tatton N. A. and Kish S. J. (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77, 1037-1048.
41. Tobe T., Nakajo S., Tanaka A., Mitoya A., Omata K., Nakaya K., Tomita M., and Nakamura Y. (1992) Cloning and characterization of the cDNA encoding a novel brain-specific 14-kDa protein. J. Neurochem. 59, 1624-1629.
42. Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D. A., Kondo J., Ihara Y., and Saitoh T. (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 90, 11282-11286.
43. Withers G. S., George J. M., Banker G. A., and Clayton D. F. (1997) Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Dev. Brain Res. 99, 87-94.