Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Nature

Volumn 416, Issue 6880, 2002, Pages 507-511

  Bucciantini, Monica ^a   Giannoni, Elisa ^a   Chiti, Fabrizio ^a,b   Baroni, Fabiana ^a   Taddei, Niccolò ^a   Ramponi, Giampietro ^a   Dobson, Christopher M ^b   Stefani, Massimo ^a  

^a Dipartimento di Scienze Biochimiche   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BIOLOGICAL MATERIALS PRESERVATION; ESCHERICHIA COLI; PROTEINS; TOXICITY;

FIBRILS;

DISEASES;

PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BRAIN SPONGIOSIS; CELL FUNCTION; CYTOTOXICITY; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; NERVE DEGENERATION; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FAMILY; PROTEIN FOLDING; TOXICITY TESTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ALZHEIMER DISEASE; ANIMALS; BACTERIAL PROTEINS; CYTOTOXINS; EVOLUTION; HUMANS; MICE; NEURODEGENERATIVE DISEASES; PC12 CELLS; PROTEIN FOLDING; RATS; RECOMBINANT PROTEINS; SENILE PLAQUES; SRC HOMOLOGY DOMAINS;

BOVINAE; ESCHERICHIA COLI;

EID: 0037041420     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/416507a     Document Type: Article

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