메뉴 건너뛰기




Volumn 404, Issue 6776, 2000, Pages 394-398

A Drosophila model of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

EID: 0034704752     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35006074     Document Type: Article
Times cited : (1812)

References (30)
  • 1
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos, M. H. et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047 (1997).
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 2
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
    • Krüger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106-108 (1998).
    • (1998) Nature Genet. , vol.18 , pp. 106-108
    • Krüger, R.1
  • 4
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. α-Synuclein filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 5
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba, M. et al. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879-884 (1998).
    • (1998) Am. J. Pathol. , vol.152 , pp. 879-884
    • Baba, M.1
  • 6
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 7
    • 18544392423 scopus 로고    scopus 로고
    • Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    • Warrick, J. M. et al. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell 93, 939-949 (1998).
    • (1998) Cell , vol.93 , pp. 939-949
    • Warrick, J.M.1
  • 8
    • 0023002408 scopus 로고
    • Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase
    • Budnik, V., Martin-Morris, L. & White, K. Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase. J. Neurosci. 6, 3682-3691 (1986).
    • (1986) J. Neurosci. , vol.6 , pp. 3682-3691
    • Budnik, V.1    Martin-Morris, L.2    White, K.3
  • 9
    • 0023866322 scopus 로고
    • Catecholamine-containing neurons in Drosophila melanogaster. Distribution and development
    • Budnik, V. & White, L. Catecholamine-containing neurons in Drosophila melanogaster. Distribution and development. J. Comp. Neurol. 268, 400-413 (1988).
    • (1988) J. Comp. Neurol. , vol.268 , pp. 400-413
    • Budnik, V.1    White, L.2
  • 10
    • 0027943318 scopus 로고
    • Temporal and spatial development of serotonin and dopamine neurons in the Drosophila CNS
    • Lundell, M. J. & Hirsh, J. Temporal and spatial development of serotonin and dopamine neurons in the Drosophila CNS. Dev. Biol. 165, 385-396 (1994).
    • (1994) Dev. Biol. , vol.165 , pp. 385-396
    • Lundell, M.J.1    Hirsh, J.2
  • 11
    • 0025763177 scopus 로고
    • Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease
    • Gibbs, W. R. G. & Lees, A. J. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 54, 388-396 (1991).
    • (1991) J. Neurol. Neurosurg. Psychiatry , vol.54 , pp. 388-396
    • Gibbs, W.R.G.1    Lees, A.J.2
  • 12
    • 0022499321 scopus 로고
    • The structural brain mutant Vacuolar medulla of Drosophila melanogaster with specific behavioral defects and cell degeneration in the adult
    • Coombe, P. E. & Heisenberg, M. The structural brain mutant Vacuolar medulla of Drosophila melanogaster with specific behavioral defects and cell degeneration in the adult. J. Neurogenet. 3, 135-158 (1986).
    • (1986) J. Neurogenet. , vol.3 , pp. 135-158
    • Coombe, P.E.1    Heisenberg, M.2
  • 13
    • 0027241846 scopus 로고
    • Defective glia in the Drosophila brain degeneration mutant drop-dead
    • Buchanan, R. L. & Benzer, S. Defective glia in the Drosophila brain degeneration mutant drop-dead. Neuron 10, 839-850 (1993).
    • (1993) Neuron , vol.10 , pp. 839-850
    • Buchanan, R.L.1    Benzer, S.2
  • 14
    • 0026348872 scopus 로고
    • Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway
    • Jellinger, K. A. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Mol. Chem. Neuropathol. 14, 153-197 (1991).
    • (1991) Mol. Chem. Neuropathol. , vol.14 , pp. 153-197
    • Jellinger, K.A.1
  • 15
    • 0023856152 scopus 로고
    • Serotonin-containing neurons in Drosophila melanogaster: Development and distribution
    • Vallés, A. M. & White, K. Serotonin-containing neurons in Drosophila melanogaster: Development and distribution. J. Comp. Neurol. 268, 414-428 (1988).
    • (1988) J. Comp. Neurol. , vol.268 , pp. 414-428
    • Vallés, A.M.1    White, K.2
  • 16
    • 0023931333 scopus 로고
    • Lewy bodies are ubiquitinated: A light and electron microscopic immunocytochemical study
    • Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M. & Ihara, Y. Lewy bodies are ubiquitinated: a light and electron microscopic immunocytochemical study. Acta Neuropathol. 75, 345-353 (1988).
    • (1988) Acta Neuropathol. , vol.75 , pp. 345-353
    • Kuzuhara, S.1    Mori, H.2    Izumiyama, N.3    Yoshimura, M.4    Ihara, Y.5
  • 17
    • 0024424234 scopus 로고
    • Diffuse Lewy body disease: Light and electron microscopic immunocytochemistry of senile plaques
    • Dickson, D. W. et al. Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol. 78, 572-584 (1987).
    • (1987) Acta Neuropathol. , vol.78 , pp. 572-584
    • Dickson, D.W.1
  • 19
    • 0018103643 scopus 로고
    • On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster
    • Ganetzky, B. & Flanagan, J. R. On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster. Exp. Gerontol. 13, 189-196 (1978).
    • (1978) Exp. Gerontol. , vol.13 , pp. 189-196
    • Ganetzky, B.1    Flanagan, J.R.2
  • 20
    • 0026528074 scopus 로고
    • Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity
    • Le Bourg, E. & Lints, F. A. Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity. Gerontology 38, 59-64 (1992).
    • (1992) Gerontology , vol.38 , pp. 59-64
    • Le Bourg, E.1    Lints, F.A.2
  • 22
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
    • Conway, K. A., Harper, J. D. & Lansbury, P. T. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nature Med. 4, 1318-1320 (1998).
    • (1998) Nature Med. , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 23
    • 0033515471 scopus 로고    scopus 로고
    • Both familial Parkinson's disease mutations accelerate α-synuclein aggregation
    • Narhi, L. et al. Both familial Parkinson's disease mutations accelerate α-synuclein aggregation. J. Biol. Chem. 274, 9843-9846 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 9843-9846
    • Narhi, L.1
  • 24
    • 0032573597 scopus 로고    scopus 로고
    • Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments
    • El-Agnaf, O. M. A. et al. Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments. FEBS Lett. 440, 71-75 (1998).
    • (1998) FEBS Lett. , vol.440 , pp. 71-75
    • El-Agnaf, O.M.A.1
  • 25
    • 0033565874 scopus 로고    scopus 로고
    • α-synuclein shares physical and functional homology with 14-3-3 proteins
    • Ostreova, N. et al. α-synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19, 5782-5791 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 5782-5791
    • Ostreova, N.1
  • 26
    • 15144361589 scopus 로고    scopus 로고
    • The cDNA cloning and ontogeny of mouse α-synuclein
    • Hong, L. et al. The cDNA cloning and ontogeny of mouse α-synuclein. NeuroReport 9, 1239-1243 (1998).
    • (1998) NeuroReport , vol.9 , pp. 1239-1243
    • Hong, L.1
  • 27
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
    • Masliah, E. et al. Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269 (2000).
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1
  • 28
    • 0034708147 scopus 로고    scopus 로고
    • Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster
    • in the press
    • Li, H., Chaney, S., Forte, M. & Hirsh, J. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Curr. Biol. (in the press).
    • Curr. Biol.
    • Li, H.1    Chaney, S.2    Forte, M.3    Hirsh, J.4
  • 29
    • 0023880221 scopus 로고
    • The locus elav of Drosophila melanogaster is expressed in all neurons at all developmental stages
    • Robinow, S. & White, L. The locus elav of Drosophila melanogaster is expressed in all neurons at all developmental stages. Dev. Biol. 126, 294-303 (1988).
    • (1988) Dev. Biol. , vol.126 , pp. 294-303
    • Robinow, S.1    White, L.2
  • 30
    • 0027515798 scopus 로고
    • Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein
    • Ellis M., O'Neill, E. & Rubin, G. Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development 119, 855-865 (1993).
    • (1993) Development , vol.119 , pp. 855-865
    • Ellis, M.1    O'Neill, E.2    Rubin, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.